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XRCC5 Gene Record

  • Summary
  • Interactions
  • Claims
  • XRCC5 7520

    Alternate Names:

    7520
    X-RAY REPAIR CROSS COMPLEMENTING 5
    XRCC5
    KARP-1
    KARP1
    KU80
    KUB2
    Ku86
    NFIV
    194364
    12833
    ENSG00000079246
    OTTHUMG00000133059
    PA37425
    X-ray repair cross-complementing protein 5
    P13010

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    KINASE

    Publications:

    Shih et al., 2005, Ku86 modulates DNA topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian cells., Cancer Res.
    Raaphorst et al., 2005, Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair., Oncol. Rep.
    Munshi et al., 2005, Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity., Clin. Cancer Res.
    Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res
  • TRIBUTYRIN   XRCC5

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16000590


    Sources:
    NCI

  • PHENYLBUTANOIC ACID   XRCC5

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16000590


    Sources:
    NCI

  • THALIDOMIDE   XRCC5

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21435719


    Sources:
    PharmGKB

  • CAMPTOTHECIN   XRCC5

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16230379


    Sources:
    NCI

  • CISPLATIN   XRCC5

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15944802


    Sources:
    NCI

  • Ensembl: ENSG00000079246

    • Version: 101_38

    Alternate Names:
    XRCC5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: XRCC5

    • Version: 18-August-2020

    Alternate Names:
    PA37425 PharmGKB ID

    Gene Info:

    Publications:
    Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res

  • NCI: XRCC5

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Shih et al., 2005, Ku86 modulates DNA topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian cells., Cancer Res.
    Raaphorst et al., 2005, Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair., Oncol. Rep.
    Arrington et al., 2000, Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects., Free Radic. Biol. Med.

  • Pharos: XRCC5

    • Version: 01-February-2022

    Alternate Names:
    X-ray repair cross-complementing protein 5 Gene Name
    P13010 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21