DGIdb - XRCC5 Gene Record

XRCC5 7520 Drug Resistance

Alternate Names:

7520
X-RAY REPAIR CROSS COMPLEMENTING 5
XRCC5
KARP-1
KARP1
KU80
KUB2
Ku86
NFIV
194364
12833
ENSG00000079246
OTTHUMG00000133059
G22P2
P13010
PA37425
X-ray repair cross-complementing protein 5

Gene Info:

Gene Biotype	PROTEIN_CODING

(1 More Sources)

Gene Categories: Category Details

KINASE
DRUG RESISTANCE

Publications:

Shih et al., 2005, Ku86 modulates DNA topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian cells., Cancer Res.
Raaphorst et al., 2005, Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair., Oncol. Rep.
Munshi et al., 2005, Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity., Clin. Cancer Res.
Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res

TRIBUTYRIN XRCC5

Interaction Score: 5.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16000590

Sources:
NCI
PHENYLBUTANOIC ACID XRCC5

Interaction Score: 1.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16000590

Sources:
NCI
THALIDOMIDE XRCC5

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21435719

Sources:
PharmGKB
CAMPTOTHECIN XRCC5

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16230379

Sources:
NCI
CISPLATIN XRCC5

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15944802

Sources:
NCI

Ensembl: ENSG00000079246
- Version: 101_38
Alternate Names:

XRCC5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
PharmGKB: XRCC5
- Version: 18-August-2020
Alternate Names:

PA37425 PharmGKB ID

Gene Info:

Publications:

Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res

NCI: XRCC5

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Shih et al., 2005, Ku86 modulates DNA topoisomerase I-mediated radiosensitization, but not cytotoxicity, in mammalian cells., Cancer Res.

Raaphorst et al., 2005, Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair., Oncol. Rep.

Arrington et al., 2000, Enhanced sensitivity and long-term G2 arrest in hydrogen peroxide-treated Ku80-null cells are unrelated to DNA repair defects., Free Radic. Biol. Med.

Pharos: XRCC5
- Version: 03-September-2020
Alternate Names:

X-ray repair cross-complementing protein 5 Gene Name

P13010 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: XRCC5
- Version: 05-September-2020
Alternate Names:

G22P2 GO Gene Synonym

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

X-ray repair cross-complementing protein 5	Gene Name
P13010	UniProt ID

XRCC5 Gene Record

XRCC5 7520 Drug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TRIBUTYRIN XRCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16000590

Sources: NCI

PHENYLBUTANOIC ACID XRCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16000590

Sources: NCI

THALIDOMIDE XRCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21435719

Sources: PharmGKB

CAMPTOTHECIN XRCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16230379

Sources: NCI

CISPLATIN XRCC5

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15944802

Sources: NCI

Ensembl: ENSG00000079246

Alternate Names: XRCC5 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: XRCC5

Alternate Names: PA37425 PharmGKB ID

Gene Info:

Publications: Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res

NCI: XRCC5

Alternate Names:

Gene Info:

Pharos: XRCC5

Alternate Names: X-ray repair cross-complementing protein 5 Gene Name P13010 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

GO: XRCC5

Alternate Names: G22P2 GO Gene Synonym

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
16000590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16000590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21435719

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16230379

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15944802

Sources:
NCI

Alternate Names:

XRCC5 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA37425 PharmGKB ID

Publications:

Cibeira MT et al., 2011, Impact on response and survival of DNA repair single nucleotide polymorphisms in relapsed or refractory multiple myeloma patients treated with thalidomide., Leuk Res

Alternate Names:

X-ray repair cross-complementing protein 5 Gene Name

P13010 UniProt ID

Gene Categories:

KINASE

Alternate Names:

G22P2 GO Gene Synonym

Gene Categories:

DRUG RESISTANCE