DGIdb - XRCC1 Gene Record

XRCC1 7515 Drug Resistance

Alternate Names:

7515
X-RAY REPAIR CROSS COMPLEMENTING 1
XRCC1
RCC
SCAR26
194360
12828
ENSG00000073050
OTTHUMG00000182699
6144
PA369

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DNA REPAIR
DRUG RESISTANCE

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer
Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.
Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.
Marsh et al., 2007, Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer., J. Clin. Oncol.
Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol
Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics
Khrunin AV et al., 2010, Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients., Pharmacogenomics J

DOCETAXEL XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer
VINORELBINE XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer
CARBOPLATIN XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.
VITAMIN E XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

PLATINUM XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Marsh et al., 2007, Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer., J. Clin. Oncol.

CISPLATIN XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.
FLUOROURACIL XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol

CYCLOPHOSPHAMIDE XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

Khrunin AV et al., 2010, Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients., Pharmacogenomics J

GEMCITABINE XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer
DOXORUBICIN XRCC1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000073050
- Version: 101_38
Alternate Names:

XRCC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: XRCC1

Version: 18-August-2020

Alternate Names:

PA369 PharmGKB ID

Gene Info:

Publications:

Khrunin AV et al., 2010, Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients., Pharmacogenomics J

Khrunin A et al., 2012, Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins., Pharmacogenomics

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

CIViC: XRCC1

Version: 14-September-2020

Alternate Names:

7515 Entrez Gene ID

6144 CIViC Gene ID

Gene Info:

Publications:

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

NCI: XRCC1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Marsh et al., 2007, Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer., J. Clin. Oncol.

Andersson et al., 1996, Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs., Cancer Chemother. Pharmacol.

Tempus: XRCC1
- Version: 11-November-2018
Alternate Names:

XRCC1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: XRCC1
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

DRUG RESISTANCE

Publications:

XRCC1 Gene Record

XRCC1 7515 Drug Resistance

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Marsh et al., 2007, Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer., J. Clin. Oncol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000073050

Alternate Names: XRCC1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: XRCC1

Alternate Names: PA369 PharmGKB ID

Gene Info:

CIViC: XRCC1

Alternate Names: 7515 Entrez Gene ID 6144 CIViC Gene ID

Gene Info:

NCI: XRCC1

Alternate Names:

Gene Info:

Tempus: XRCC1

Alternate Names: XRCC1 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

GO: XRCC1

Alternate Names:

Gene Info:

Gene Categories: DRUG RESISTANCE

Publications:

Interaction Types & Directionality:

n/a

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality:

n/a

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality:

n/a

Publications:

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

Interaction Types & Directionality:

n/a

Publications:

Misra et al., 2003, Polymorphisms in the DNA repair genes XPD, XRCC1, XRCC3, and APE/ref-1, and the risk of lung cancer among male smokers in Finland., Cancer Lett.

Interaction Types & Directionality:

n/a

Publications:

Marsh et al., 2007, Pharmacogenetic assessment of toxicity and outcome after platinum plus taxane chemotherapy in ovarian cancer: the Scottish Randomised Trial in Ovarian Cancer., J. Clin. Oncol.

Interaction Types & Directionality:

n/a

Publications:

Chung et al., 2006, XRCC1 R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer., Gynecol. Oncol.

Interaction Types & Directionality:

n/a

Publications:

Lee KH et al., 2013, Pharmacogenetic analysis of adjuvant FOLFOX for Korean patients with colon cancer., Cancer Chemother Pharmacol

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Sun et al., 2009, Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients., Lung Cancer

Interaction Types & Directionality:

n/a

Alternate Names:

XRCC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA369 PharmGKB ID

Alternate Names:

7515 Entrez Gene ID

6144 CIViC Gene ID

Alternate Names:

XRCC1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

DRUG RESISTANCE