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XPO1 Gene Record

  • Summary
  • Interactions
  • Claims
  • XPO1 7514 Clinically Actionable

    Alternate Names:

    7514
    EXPORTIN 1
    XPO1
    CRM1
    emb
    exp1
    602559
    12825
    ENSG00000082898
    OTTHUMG00000152316
    Chromosome region maintenance 1 protein homolog
    Exportin-1
    O14980
    PA37418
    T51407
    CRM-1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Turner JG et al., 2014, Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents., Semin Cancer Biol
    Van Neck T et al., 2008, Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action., Bioorg Med Chem
    Chan SL et al., 2017, Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients., PLoS One
    Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)
    Wach JY et al., 2010, The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport., Bioorg Med Chem Lett
    Tamura S et al., 2010, Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus., Bioorg Med Chem Lett
  • SELINEXOR   XPO1

    Interaction Score: 30.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Exportin-1 inhibitor
    Direct Interaction yes

    PMIDs:
    24631834


    Sources:
    ChemblInteractions TTD

  • LEPTOMYCIN B   XPO1

    Interaction Score: 20.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18835718


    Sources:
    DTC

  • CBS-9106   XPO1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OSTHOLE   XPO1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20493693


    Sources:
    DTC

  • GONIOTHALAMIN   XPO1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20381347


    Sources:
    DTC

  • ISONIAZID   XPO1

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29036176 22341855


    Sources:
    PharmGKB

  • Ensembl: ENSG00000082898

    • Version: 101_38

    Alternate Names:
    XPO1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: XPO1

    • Version: 18-August-2020

    Alternate Names:
    PA37418 PharmGKB ID

    Gene Info:

    Publications:
    Nanashima K et al., 2012, Genetic variants in antioxidant pathway: risk factors for hepatotoxicity in tuberculosis patients., Tuberculosis (Edinb)
    Chan SL et al., 2017, Association and clinical utility of NAT2 in the prediction of isoniazid-induced liver injury in Singaporean patients., PLoS One
    He X et al., 2019, The A/A Genotype of XPO1 rs4430924 Is Associated With Higher Risk of Antituberculosis Drug-Induced Hepatotoxicity in Chinese Patients., J Clin Pharmacol

  • TTD: Exportin-1

    • Version: 2020.06.01

    Alternate Names:
    XPO1 TTD Gene Abbreviation
    T51407 TTD Target ID

    Gene Info:

    Publications:
    Turner JG et al., 2014, Inhibition of CRM1-dependent nuclear export sensitizes malignant cells to cytotoxic and targeted agents., Semin Cancer Biol

  • DTC: XPO1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Wach JY et al., 2010, The cytotoxic styryl lactone goniothalamin is an inhibitor of nucleocytoplasmic transport., Bioorg Med Chem Lett
    Van Neck T et al., 2008, Inhibition of the CRM1-mediated nucleocytoplasmic transport by N-azolylacrylates: structure-activity relationship and mechanism of action., Bioorg Med Chem
    Tamura S et al., 2010, Prenylcoumarin with Rev-export inhibitory activity from Cnidii Monnieris Fructus., Bioorg Med Chem Lett

  • ChemblInteractions: CRM1

    • Version: chembl_23

    Alternate Names:
    CRM1 GENE_SYMBOL
    XPO1 GENE_SYMBOL
    Exportin-1 UNIPROT

    Gene Info:

    Publications:

  • Tempus: XPO1

    • Version: 11-November-2018

    Alternate Names:
    XPO1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: XPO1

    • Version: 01-February-2022

    Alternate Names:
    Exportin-1 Gene Name
    O14980 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: XPO1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: XPO1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: XPO1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Oncomine: XPO1

    • Version: v3

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21