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XIAP Gene Record

  • Summary
  • Interactions
  • Claims
  • XIAP 331 Druggable GenomeClinically Actionable

    Alternate Names:

    331
    X-LINKED INHIBITOR OF APOPTOSIS
    XIAP
    API3
    BIRC4
    IAP-3
    ILP1
    MIHA
    XLP2
    hIAP-3
    hIAP3
    300079
    592
    ENSG00000101966
    OTTHUMG00000022336
    X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
    P98170
    BE0001156
    2790
    PA25361
    T16769
    E3 ubiquitin-protein ligase XIAP
    NM_001167
    NP_001158

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis
    Gene Biotype PROTEIN_CODING
    GuideToPharmacology Gene Category Name Inhibitors of apoptosis (IAP) protein family
    GuideToPharmacology Gene Category ID 889
    (11 More Sources)

    Gene Categories: Category Details

    KINASE
    PROTEASE INHIBITOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Chow et al., 2003, Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation., Biochem. Pharmacol.
    Duechler et al., 2005, In vitro cytotoxic effect of proteasome inhibitor bortezomib in combination with purine nucleoside analogues on chronic lymphocytic leukaemia cells., Eur. J. Haematol.
    Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res
    Porosnicu et al., 2001, Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells., Leukemia
    Nimmanapalli et al., 2001, Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells., Clin. Cancer Res.
    Sun H et al., 2011, Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity., J Med Chem
    Vaziri et al., c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis., Anticancer Res.
    Li et al., 2001, Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins., Endocrinology
    Nomura et al., Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells., Urol. Oncol.
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.
    Alas et al., 2002, Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma., Clin. Cancer Res.
    Kitada et al., 2000, Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia., Blood
    Gao et al., 2004, Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol., Mol. Pharmacol.
    Motwani et al., 2001, Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts., Clin. Cancer Res.
    Piva et al., 2005, 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins., Blood
    Jazirehi et al., 2001, Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis., Clin. Cancer Res.
    Jia et al., 2003, Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways., Blood
    Shankar et al., 2004, UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines., J. Neurochem.
    Orzáez M et al., 2011, Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain., Apoptosis
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • CHEMBL1230662   XIAP

    Interaction Score: 9.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235 17139284 17016423


    Sources:
    DrugBank

  • CHEMBL1230661   XIAP

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • BIRINAPANT   XIAP

    Interaction Score: 2.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TTD TALC GuideToPharmacology

  • CHEMBL481422   XIAP

    Interaction Score: 2.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    21462933


    Sources:
    DTC GuideToPharmacology

  • GDC-0917   XIAP

    Interaction Score: 2.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name CUDC-427

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AT-406   XIAP

    Interaction Score: 2.37

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

    PMIDs:
    25520882


    Sources:
    TTD TALC GuideToPharmacology

  • LCL-161   XIAP

    Interaction Score: 1.58

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Details of the Assay for Interaction Assay uses recombinantly expressed BIR3 domain of XIAP
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    TALC GuideToPharmacology

  • GDC-0152   XIAP

    Interaction Score: 1.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction BIR3 domain of hXIAP
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    TTD GuideToPharmacology

  • CHEMBL504559   XIAP

    Interaction Score: 0.79

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356)
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ETOPOSIDE PHOSPHATE   XIAP

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14666661


    Sources:
    NCI

  • EMAPALUMAB   XIAP

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA PharmGKB

  • IDRONOXIL   XIAP

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • ALVOCIDIB   XIAP

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10887097 15235103 11751522


    Sources:
    NCI

  • TANESPIMYCIN   XIAP

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738674


    Sources:
    NCI

  • UCN-01   XIAP

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738674 15255949


    Sources:
    NCI

  • DEQUALINIUM   XIAP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21340509


    Sources:
    DrugBank

  • RITUXIMAB   XIAP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11895917


    Sources:
    NCI

  • CLADRIBINE   XIAP

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12948851 15813915


    Sources:
    NCI

  • ADRIAMYCIN   XIAP

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11751478


    Sources:
    NCI

  • FLUDARABINE   XIAP

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15059916


    Sources:
    NCI

  • TROGLITAZONE   XIAP

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15498850


    Sources:
    NCI

  • IMATINIB   XIAP

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11368438 11234890


    Sources:
    NCI

  • BORTEZOMIB   XIAP

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813915


    Sources:
    NCI

  • CISPLATIN   XIAP

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11145600 15610860


    Sources:
    NCI

  • Ensembl: ENSG00000101966

    • Version: 101_38

    Alternate Names:
    XIAP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P98170

    • Version: January-2014

    Alternate Names:
    XIAP Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis

    Publications:

  • GuideToPharmacology: 331

    • Version: 29-September-2020

    Alternate Names:
    592 HUGO Gene ID
    592 HUGO Gene Symbol
    X-linked inhibitor of apoptosis HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name Inhibitors of apoptosis (IAP) protein family
    GuideToPharmacology Gene Category ID 889

    Publications:

  • DrugBank: BE0001156

    • Version: 5.1.7

    Alternate Names:
    XIAP DrugBank Gene Name
    P98170 UniProt Accession
    331 Entrez Gene Id

    Gene Info:

    Publications:
    Orzáez M et al., 2011, Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain., Apoptosis
    Shaw TJ et al., 2008, Downregulation of XIAP expression in ovarian cancer cells induces cell death in vitro and in vivo., Int J Cancer
    Lacasse EC et al., 2005, Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/ GEM640., Ann N Y Acad Sci

  • TTD: X-linked inhibitor of apoptosis protein

    • Version: 2020.06.01

    Alternate Names:
    XIAP TTD Gene Abbreviation
    T16769 TTD Target ID

    Gene Info:

    Publications:
    Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

  • NCI: XIAP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Li et al., 2001, Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins., Endocrinology
    Nomura et al., Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells., Urol. Oncol.
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.

  • DTC: XIAP

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Sun H et al., 2011, Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity., J Med Chem

  • TALC: XIAP

    • Version: 12-May-2016

    Alternate Names:
    XIAP Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000101966

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101966 Gene Symbol
    XIAP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: XIAP

    • Version: 18-August-2020

    Alternate Names:
    PA25361 PharmGKB ID

    Gene Info:

    Publications:

  • Pharos: XIAP

    • Version: 03-September-2020

    Alternate Names:
    E3 ubiquitin-protein ligase XIAP Gene Name
    P98170 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

  • dGene: XIAP

    • Version: 27-Jun-2013

    Alternate Names:
    331 Gene ID
    API3 dGene Synonym
    BIRC4 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • ClearityFoundationClinicalTrial: XIAP

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: XIAP

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: XIAP

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21