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XIAP Gene Record

  • Summary
  • Interactions
  • Claims
  • XIAP 331 Druggable GenomeClinically Actionable

    Alternate Names:

    331
    X-LINKED INHIBITOR OF APOPTOSIS
    XIAP
    API3
    BIRC4
    IAP-3
    ILP1
    MIHA
    XLP2
    hIAP-3
    hIAP3
    300079
    592
    ENSG00000101966
    OTTHUMG00000022336
    X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
    P98170
    PA25361
    T16769
    IAP3
    E3 ubiquitin-protein ligase XIAP

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis
    Gene Biotype PROTEIN_CODING
    (10 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    KINASE
    PROTEASE INHIBITOR
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Chow et al., 2003, Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation., Biochem. Pharmacol.
    Duechler et al., 2005, In vitro cytotoxic effect of proteasome inhibitor bortezomib in combination with purine nucleoside analogues on chronic lymphocytic leukaemia cells., Eur. J. Haematol.
    Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res
    Porosnicu et al., 2001, Co-treatment with As2O3 enhances selective cytotoxic effects of STI-571 against Brc-Abl-positive acute leukemia cells., Leukemia
    Nimmanapalli et al., 2001, Cotreatment with STI-571 enhances tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL or apo-2L)-induced apoptosis of Bcr-Abl-positive human acute leukemia cells., Clin. Cancer Res.
    Sun H et al., 2011, Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity., J Med Chem
    Vaziri et al., c-IAP1 is overexpressed in HL-60 cells selected for doxorubicin resistance: effects on etoposide-induced apoptosis., Anticancer Res.
    Nomura et al., Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells., Urol. Oncol.
    Li et al., 2001, Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins., Endocrinology
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.
    Alas et al., 2002, Rituximab modifies the cisplatin-mitochondrial signaling pathway, resulting in apoptosis in cisplatin-resistant non-Hodgkin's lymphoma., Clin. Cancer Res.
    Gao et al., 2004, Contribution of disruption of the nuclear factor-kappaB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol., Mol. Pharmacol.
    Motwani et al., 2001, Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts., Clin. Cancer Res.
    Kitada et al., 2000, Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia., Blood
    Piva et al., 2005, 15-Deoxy-delta 12,14-prostaglandin J2 induces apoptosis in human malignant B cells: an effect associated with inhibition of NF-kappa B activity and down-regulation of antiapoptotic proteins., Blood
    Jazirehi et al., 2001, Adriamycin sensitizes the adriamycin-resistant 8226/Dox40 human multiple myeloma cells to Apo2L/tumor necrosis factor-related apoptosis-inducing ligand-mediated (TRAIL) apoptosis., Clin. Cancer Res.
    Jia et al., 2003, Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways., Blood
    Shankar et al., 2004, UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines., J. Neurochem.
  • CHEMBL481422   XIAP

    Interaction Score: 6.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21462933


    Sources:
    DTC

  • GDC-0152   XIAP

    Interaction Score: 3.09

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • GDC-0917   XIAP

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name CUDC-427

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • AT-406   XIAP

    Interaction Score: 2.32

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    25520882


    Sources:
    TALC TTD

  • BIRINAPANT   XIAP

    Interaction Score: 2.06

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC TTD

  • LCL-161   XIAP

    Interaction Score: 1.03

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • ETOPOSIDE PHOSPHATE   XIAP

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14666661


    Sources:
    NCI

  • EMAPALUMAB   XIAP

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • IDRONOXIL   XIAP

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • ALVOCIDIB   XIAP

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15235103 11751522 10887097


    Sources:
    NCI

  • CLADRIBINE   XIAP

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12948851 15813915


    Sources:
    NCI

  • TANESPIMYCIN   XIAP

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738674


    Sources:
    NCI

  • UCN-01   XIAP

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15255949 12738674


    Sources:
    NCI

  • RITUXIMAB   XIAP

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11895917


    Sources:
    NCI

  • ADRIAMYCIN   XIAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11751478


    Sources:
    NCI

  • FLUDARABINE   XIAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15059916


    Sources:
    NCI

  • TROGLITAZONE   XIAP

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15498850


    Sources:
    NCI

  • IMATINIB   XIAP

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11368438 11234890


    Sources:
    NCI

  • BORTEZOMIB   XIAP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813915


    Sources:
    NCI

  • CISPLATIN   XIAP

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15610860 11145600


    Sources:
    NCI

  • Ensembl: ENSG00000101966

    • Version: 101_38

    Alternate Names:
    XIAP Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P98170

    • Version: January-2014

    Alternate Names:
    XIAP Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Inhibitor of apoptosis

    Publications:

  • TTD: X-linked inhibitor of apoptosis protein

    • Version: 2020.06.01

    Alternate Names:
    XIAP TTD Gene Abbreviation
    T16769 TTD Target ID

    Gene Info:

    Publications:
    Liu N et al., 2014, Debio 1143, an antagonist of multiple inhibitor-of-apoptosis proteins, activates apoptosis and enhances radiosensitization of non-small cell lung cancer cells in vitro., Am J Cancer Res

  • NCI: XIAP

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Li et al., 2001, Human ovarian cancer and cisplatin resistance: possible role of inhibitor of apoptosis proteins., Endocrinology
    Nomura et al., Cisplatin inhibits the expression of X-linked inhibitor of apoptosis protein in human LNCaP cells., Urol. Oncol.
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.

  • DTC: XIAP

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Sun H et al., 2011, Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity., J Med Chem

  • TALC: XIAP

    • Version: 12-May-2016

    Alternate Names:
    XIAP Gene Symbol

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000101966

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000101966 Gene Symbol
    XIAP Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: XIAP

    • Version: 18-August-2020

    Alternate Names:
    PA25361 PharmGKB ID

    Gene Info:

    Publications:

  • GO: XIAP

    • Version: 01-February-2022

    Alternate Names:
    API3 GO Gene Synonym
    BIRC4 GO Gene Synonym
    IAP3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • dGene: XIAP

    • Version: 27-Jun-2013

    Alternate Names:
    331 Gene ID
    API3 dGene Synonym
    BIRC4 dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • Pharos: XIAP

    • Version: 01-February-2022

    Alternate Names:
    E3 ubiquitin-protein ligase XIAP Gene Name
    P98170 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE, ENZYME

    Publications:

  • ClearityFoundationClinicalTrial: XIAP

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: XIAP

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FDA: XIAP

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21