331 |
X-LINKED INHIBITOR OF APOPTOSIS |
XIAP |
API3 |
BIRC4 |
IAP-3 |
ILP1 |
MIHA |
XLP2 |
hIAP-3 |
hIAP3 |
300079 |
592 |
ENSG00000101966 |
OTTHUMG00000022336 |
X-LINKED INHIBITOR OF APOPTOSIS PROTEIN |
P98170 |
BE0001156 |
2790 |
PA25361 |
T16769 |
E3 ubiquitin-protein ligase XIAP |
NM_001167 |
NP_001158 |
Target Class | Miscellaneous |
Target Subclass | Inhibitor of apoptosis |
Gene Biotype | PROTEIN_CODING |
GuideToPharmacology Gene Category Name | Inhibitors of apoptosis (IAP) protein family |
GuideToPharmacology Gene Category ID | 889 |
KINASE |
PROTEASE INHIBITOR |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
antagonist (inhibitory) |
Notes | |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
n/a |
Novel drug target | Novel Target |
Trial Name | CUDC-427 |
antagonist (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Antagonist |
antagonist (inhibitory) |
inhibitor (inhibitory) |
Notes | |
Details of the Assay for Interaction | Assay uses recombinantly expressed BIR3 domain of XIAP |
Specific Action of the Ligand | Inhibition |
antagonist (inhibitory) |
Details of the Assay for Interaction | BIR3 domain of hXIAP |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
antagonist (inhibitory) |
Details of the Assay for Interaction | Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356) |
Specific Action of the Ligand | Antagonist |
Endogenous Drug? | False |
n/a |
XIAP | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
XIAP | Gene Symbol |
Target Class | Miscellaneous |
Target Subclass | Inhibitor of apoptosis |
592 | HUGO Gene ID |
592 | HUGO Gene Symbol |
X-linked inhibitor of apoptosis | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Inhibitors of apoptosis (IAP) protein family |
GuideToPharmacology Gene Category ID | 889 |
XIAP | DrugBank Gene Name |
P98170 | UniProt Accession |
331 | Entrez Gene Id |
XIAP | TTD Gene Abbreviation |
T16769 | TTD Target ID |
XIAP | Gene Symbol |
ENSG00000101966 | Gene Symbol |
XIAP | Ensembl Id |
DRUGGABLE GENOME |
PA25361 | PharmGKB ID |
E3 ubiquitin-protein ligase XIAP | Gene Name |
P98170 | UniProt ID |
KINASE, ENZYME |
331 | Gene ID |
API3 | dGene Synonym |
BIRC4 | dGene Synonym |
PROTEASE INHIBITOR |
CLINICALLY ACTIONABLE |