• Interaction Score: 3.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 3.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    21462933


  • Interaction Score: 3.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Novel Target
    Trial Name CUDC-427

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • Interaction Score: 3.04

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Antagonist

  • Interaction Score: 2.03

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Details of the Assay for Interaction Assay uses recombinantly expressed BIR3 domain of XIAP
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


  • Interaction Score: 1.52

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction BIR3 domain of hXIAP
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 1.01

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Details of the Assay for Interaction Fluorescence polarization assay using hXIAP BIR3 domain (residues 241-356)
    Specific Action of the Ligand Antagonist
    Endogenous Drug? False

    PMIDs:
    None found


  • Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14666661


    Sources:
    NCI

  • Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


  • Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI

  • Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI

  • Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738674


    Sources:
    NCI

  • Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11895917


    Sources:
    NCI

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11751478


    Sources:
    NCI

  • Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15059916


    Sources:
    NCI

  • Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15498850


    Sources:
    NCI

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI

  • Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15813915


    Sources:
    NCI

  • Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:


    Sources:
    NCI