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XDH Gene Record

  • Summary
  • Interactions
  • Claims
  • XDH 7498 Druggable Genome

    Alternate Names:

    7498
    XANTHINE DEHYDROGENASE
    XDH
    XAN1
    XO
    XOR
    607633
    12805
    ENSG00000158125
    OTTHUMG00000099385
    P47989
    XDH_HUMAN
    XDHA
    XD
    Xanthine oxidoreductase
    Xanthine oxidase
    Xanthine dehydrogenase/oxidase
    PA37404
    T40954

    Gene Info:

    Target Subclass 1.17.1.4
    Target Main Class Enzymes
    Target Class Enzymes
    Target Subclass EC:1.17.1.4
    Target Subclass 1.17.3.2
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Bruce, 2006, Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout., Ann Pharmacother
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
    George et al., 2009, Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress., Vasc Health Risk Manag
    Kelley et al., 1970, Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells., J. Clin. Invest.
    Carro et al., 2010, Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
    Dincer et al., 2002, Asymptomatic hyperuricemia: to treat or not to treat., Cleve Clin J Med
    Okamoto, 2008, [Inhibitors of xanthine oxidoreductase]., Nippon Rinsho
    Higgins et al., 2009, The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease., Cardiovasc Psychiatry Neurol
    Pacher et al., 2006, Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol., Pharmacol. Rev.
    Suzuki et al., 2009, Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders?, Drugs Today
    Taha et al., 2009, Effects of allopurinol on ischemia and reperfusion in rabbit livers., Transplant. Proc.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Terkeltaub, 2010, Update on gout: new therapeutic strategies and options., Nat Rev Rheumatol
    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
    Baldus et al., 2005, Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease., Free Radic. Biol. Med.
    Iwanaga et al., 2005, Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone., Drug Metab. Dispos.
    Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.
    Oliveira et al., 2005, Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria?, Curr Vasc Pharmacol
    Djuric, 1989, Reductive metabolism and DNA binding of misonidazole., Toxicol. Appl. Pharmacol.
    Roberts et al., 2007, PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor., J. Cell. Biochem.
    Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem
    Ueno et al., 1984, Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity., J. Pharmacobio-dyn.
    Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
    Grishko et al., 2005, Contribution of mitochondrial DNA repair to cell resistance from oxidative stress., J. Biol. Chem.
    Korotkina et al., 1988, [Effect of tranquilizers of the 1,4-benzodiazepine series on the xanthine oxidase activity of the rat brain]., Biull Eksp Biol Med
    Kishko et al., [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]., Ukr Biokhim Zh (1999)
    Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis
  • OXYPURINOL   XDH

    Interaction Score: 11.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name metabolite of allopurinol, Oxypurinol

    PMIDs:
    16214034 16135657


    Sources:
    TdgClinicalTrial TTD

  • TOPIROXOSTAT   XDH

    Interaction Score: 5.89

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10592235


    Sources:
    TTD

  • ALLOPURINOL SODIUM   XDH

    Interaction Score: 2.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Xanthine dehydrogenase inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYPOXANTHINE   XDH

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15632148


    Sources:
    NCI

  • MISONIDAZOLE   XDH

    Interaction Score: 1.96

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2799816


    Sources:
    NCI

  • FEBUXOSTAT   XDH

    Interaction Score: 1.96

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Xanthine dehydrogenase inhibitor
    Direct Interaction yes
    Trial Name febuxostat, TMX-67,Uloric, Adenuric, Feburic

    PMIDs:
    17132810 27798726 24915143


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • ALLOPURINOL   XDH

    Interaction Score: 1.83

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Xanthine dehydrogenase inhibitor
    Trial Name NU1618, tranilast + allopurinol

    PMIDs:
    27798726 24915143 19436671 5415686 19654053 12184468 18409526 20029618 16507884 19584965 19376361 11752352 20046204


    Sources:
    TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

  • BENZODIAZEPINE   XDH

    Interaction Score: 1.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2904285


    Sources:
    NCI

  • ROXITHROMYCIN   XDH

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • AZITHROMYCIN   XDH

    Interaction Score: 0.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • NITROFURANTOIN   XDH

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6297496


    Sources:
    NCI

  • DIDANOSINE   XDH

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23315321


    Sources:
    PharmGKB

  • CLARITHROMYCIN   XDH

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • PAPAVERINE   XDH

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11200484


    Sources:
    NCI

  • CARVEDILOL   XDH

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15853634


    Sources:
    NCI

  • ERYTHROMYCIN   XDH

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14730107


    Sources:
    NCI

  • FENTANYL   XDH

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9637647


    Sources:
    NCI

  • QUERCETIN   XDH

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21474216 6099408


    Sources:
    DTC NCI

  • THEOPHYLLINE   XDH

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • INSULIN   XDH

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17370312


    Sources:
    NCI

  • CURCUMIN   XDH

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000158125

    • Version: 101_38

    Alternate Names:
    XDH Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P47989

    • Version: 01-August-2011

    Alternate Names:
    ENSG00000158125 Ensembl Gene Id
    XDH Gene Symbol
    XDH_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 1.17.1.4
    Target Main Class Enzymes
    Target Subclass 1.17.3.2

    Publications:

  • TdgClinicalTrial: P47989

    • Version: January-2014

    Alternate Names:
    XDH Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:1.17.1.4
    Target Subclass 1.17.3.2

    Publications:

  • PharmGKB: XDH

    • Version: 18-August-2020

    Alternate Names:
    PA37404 PharmGKB ID

    Gene Info:

    Publications:
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
    Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis

  • NCI: XDH

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
    Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
    Nam et al., 2005, Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays., J. Agric. Food Chem.

  • DTC: XDH

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem

  • ChemblInteractions: XDHA

    • Version: chembl_23

    Alternate Names:
    XDHA GENE_SYMBOL
    XDH GENE_SYMBOL
    Xanthine dehydrogenase/oxidase UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000158125

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000158125 Gene Symbol
    XDH Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Xanthine dehydrogenase/oxidase

    • Version: 2020.06.01

    Alternate Names:
    XDH TTD Gene Abbreviation
    T40954 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: XDH

    • Version: 01-February-2022

    Alternate Names:
    Xanthine dehydrogenase/oxidase Gene Name
    P47989 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21