DGIdb - XDH Gene Record

XDH 7498 Druggable Genome

Alternate Names:

7498
XANTHINE DEHYDROGENASE
XDH
XAN1
XO
XOR
607633
12805
ENSG00000158125
OTTHUMG00000099385
P47989
XDH_HUMAN
XDHA
XD
Xanthine oxidoreductase
Xanthine oxidase
Xanthine dehydrogenase/oxidase
PA37404
T40954

Gene Info:

Target Subclass	1.17.1.4
Target Main Class	Enzymes
Target Class	Enzymes
Target Subclass	EC:1.17.1.4
Target Subclass	1.17.3.2
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Bruce, 2006, Febuxostat: a selective xanthine oxidase inhibitor for the treatment of hyperuricemia and gout., Ann Pharmacother
Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics
George et al., 2009, Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress., Vasc Health Risk Manag
Kelley et al., 1970, Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells., J. Clin. Invest.
Carro et al., 2010, Effects of allopurinol on uric acid concentrations, xanthine oxidoreductase activity and oxidative stress in broiler chickens., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Dincer et al., 2002, Asymptomatic hyperuricemia: to treat or not to treat., Cleve Clin J Med
Okamoto, 2008, [Inhibitors of xanthine oxidoreductase]., Nippon Rinsho
Higgins et al., 2009, The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease., Cardiovasc Psychiatry Neurol
Pacher et al., 2006, Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol., Pharmacol. Rev.
Suzuki et al., 2009, Allopurinol, an inhibitor of uric acid synthesis--can it be used for the treatment of metabolic syndrome and related disorders?, Drugs Today
Taha et al., 2009, Effects of allopurinol on ischemia and reperfusion in rabbit livers., Transplant. Proc.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Terkeltaub, 2010, Update on gout: new therapeutic strategies and options., Nat Rev Rheumatol
Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol
Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
Baldus et al., 2005, Oxypurinol improves coronary and peripheral endothelial function in patients with coronary artery disease., Free Radic. Biol. Med.
Iwanaga et al., 2005, Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone., Drug Metab. Dispos.
Youngman et al., 1982, Mechanisms of oxygen activation by nitrofurantoin and relevance to its toxicity., Biochem. Pharmacol.
Oliveira et al., 2005, Are the antioxidant properties of carvedilol important for the protection of cardiac mitochondria?, Curr Vasc Pharmacol
Djuric, 1989, Reductive metabolism and DNA binding of misonidazole., Toxicol. Appl. Pharmacol.
Roberts et al., 2007, PD98059 enhanced insulin, cytokine, and growth factor activation of xanthine oxidoreductase in epithelial cells involves STAT3 and the glucocorticoid receptor., J. Cell. Biochem.
Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem
Ueno et al., 1984, Interaction between quercetin and superoxide radicals. Reduction of the quercetin mutagenicity., J. Pharmacobio-dyn.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Grishko et al., 2005, Contribution of mitochondrial DNA repair to cell resistance from oxidative stress., J. Biol. Chem.
Korotkina et al., 1988, [Effect of tranquilizers of the 1,4-benzodiazepine series on the xanthine oxidase activity of the rat brain]., Biull Eksp Biol Med
Kishko et al., [Role of xanthine oxidase and xanthine dehydrogenase systems in thymocyte apoptosis, induced by papaverine]., Ukr Biokhim Zh (1999)
Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis

OXYPURINOL XDH

Interaction Score: 11.78

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name metabolite of allopurinol, Oxypurinol

PMIDs:
16214034 16135657

Sources:
TdgClinicalTrial TTD
TOPIROXOSTAT XDH

Interaction Score: 5.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
TTD
ALLOPURINOL SODIUM XDH

Interaction Score: 2.94

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
HYPOXANTHINE XDH

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15632148

Sources:
NCI
MISONIDAZOLE XDH

Interaction Score: 1.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2799816

Sources:
NCI
FEBUXOSTAT XDH

Interaction Score: 1.96

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

Trial Name febuxostat, TMX-67,Uloric, Adenuric, Feburic

PMIDs:
17132810 27798726 24915143

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
ALLOPURINOL XDH

Interaction Score: 1.83

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Trial Name NU1618, tranilast + allopurinol

PMIDs:
27798726 24915143 19436671 5415686 19654053 12184468 18409526 20029618 16507884 19584965 19376361 11752352 20046204

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
BENZODIAZEPINE XDH

Interaction Score: 1.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2904285

Sources:
NCI
ROXITHROMYCIN XDH

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
AZITHROMYCIN XDH

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
NITROFURANTOIN XDH

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6297496

Sources:
NCI
DIDANOSINE XDH

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23315321

Sources:
PharmGKB
CLARITHROMYCIN XDH

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
PAPAVERINE XDH

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11200484

Sources:
NCI
CARVEDILOL XDH

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15853634

Sources:
NCI
ERYTHROMYCIN XDH

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14730107

Sources:
NCI
FENTANYL XDH

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9637647

Sources:
NCI
QUERCETIN XDH

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21474216 6099408

Sources:
DTC NCI
THEOPHYLLINE XDH

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
INSULIN XDH

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17370312

Sources:
NCI
CURCUMIN XDH

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

Ensembl: ENSG00000158125
- Version: 101_38
Alternate Names:

XDH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P47989
- Version: 01-August-2011
Alternate Names:

ENSG00000158125 Ensembl Gene Id

XDH Gene Symbol

XDH_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.17.1.4

Target Main Class Enzymes

Target Subclass 1.17.3.2

Publications:
TdgClinicalTrial: P47989
- Version: January-2014
Alternate Names:

XDH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.1.4

Target Subclass 1.17.3.2

Publications:

PharmGKB: XDH

Version: 18-August-2020

Alternate Names:

PA37404 PharmGKB ID

Gene Info:

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

McDonagh EM et al., 2014, PharmGKB summary: uric acid-lowering drugs pathway, pharmacodynamics., Pharmacogenet Genomics

Vispo E et al., 2013, Genetic determinants of idiopathic noncirrhotic portal hypertension in HIV-infected patients., Clin Infect Dis

NCI: XDH

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Aktan et al., Effect of macrolide antibiotics on nitric oxide synthase and xanthine oxidase activities, and malondialdehyde level in erythrocyte of the guinea pigs with experimental otitis media with effusion., Pol J Pharmacol

Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology

Nam et al., 2005, Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays., J. Agric. Food Chem.

DTC: XDH
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem
ChemblInteractions: XDHA
- Version: chembl_23
Alternate Names:

XDHA GENE_SYMBOL

XDH GENE_SYMBOL

Xanthine dehydrogenase/oxidase UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000158125
- Version: 31-May-2017
Alternate Names:

ENSG00000158125 Gene Symbol

XDH Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TTD: Xanthine dehydrogenase/oxidase
- Version: 2020.06.01
Alternate Names:

XDH TTD Gene Abbreviation

T40954 TTD Target ID

Gene Info:

Publications:
Pharos: XDH
- Version: 01-February-2022
Alternate Names:

Xanthine dehydrogenase/oxidase Gene Name

P47989 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

Novel drug target	Established target
Trial Name	metabolite of allopurinol, Oxypurinol

Mechanism of Interaction	Xanthine dehydrogenase inhibitor
Direct Interaction	yes

ENSG00000158125	Ensembl Gene Id
XDH	Gene Symbol
XDH_HUMAN	Uniprot Id

XDHA	GENE_SYMBOL
XDH	GENE_SYMBOL
Xanthine dehydrogenase/oxidase	UNIPROT

XDH Gene Record

XDH 7498 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name metabolite of allopurinol, Oxypurinol

PMIDs: 16214034 16135657

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Xanthine dehydrogenase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15632148

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2799816

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Xanthine dehydrogenase inhibitor Direct Interaction yes Trial Name febuxostat, TMX-67,Uloric, Adenuric, Feburic

PMIDs: 17132810 27798726 24915143

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Xanthine dehydrogenase inhibitor Trial Name NU1618, tranilast + allopurinol

PMIDs: 27798726 24915143 19436671 5415686 19654053 12184468 18409526 20029618 16507884 19584965 19376361 11752352 20046204

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2904285

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6297496

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23315321

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11200484

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15853634

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14730107

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9637647

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21474216 6099408

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name metabolite of allopurinol, Oxypurinol

PMIDs:
16214034 16135657

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15632148

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2799816

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Direct Interaction yes

Trial Name febuxostat, TMX-67,Uloric, Adenuric, Feburic

PMIDs:
17132810 27798726 24915143

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Xanthine dehydrogenase inhibitor

Trial Name NU1618, tranilast + allopurinol

PMIDs:
27798726 24915143 19436671 5415686 19654053 12184468 18409526 20029618 16507884 19584965 19376361 11752352 20046204

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
2904285

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6297496

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23315321

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11200484

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15853634

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14730107

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9637647

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
21474216 6099408

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17370312

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

XDH Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000158125 Ensembl Gene Id

XDH Gene Symbol

XDH_HUMAN Uniprot Id

Gene Info:

Target Subclass 1.17.1.4

Target Main Class Enzymes

Target Subclass 1.17.3.2

Alternate Names:

XDH Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:1.17.1.4

Target Subclass 1.17.3.2

Alternate Names:

PA37404 PharmGKB ID

Publications:

Nazir N et al., 2011, Evaluation of antioxidant and antimicrobial activities of Bergenin and its derivatives obtained by chemoenzymatic synthesis., Eur J Med Chem

Alternate Names:

XDHA GENE_SYMBOL

XDH GENE_SYMBOL

Xanthine dehydrogenase/oxidase UNIPROT

Alternate Names:

ENSG00000158125 Gene Symbol

XDH Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

XDH TTD Gene Abbreviation

T40954 TTD Target ID

Alternate Names:

Xanthine dehydrogenase/oxidase Gene Name

P47989 UniProt ID