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WT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • WT1 7490 Druggable GenomeClinically ActionableDrug Resistance

    Alternate Names:

    7490
    WILMS TUMOR 1
    WT1
    AWT1
    EWS-WT1
    GUD
    NPHS4
    WAGR
    WIT-2
    WT33
    607102
    12796
    ENSG00000184937
    OTTHUMG00000039556
    49
    Wilms tumor protein
    T29960
    P19544

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    DRUG RESISTANCE
    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    TRANSCRIPTION FACTOR

    Publications:

    Virappane et al., 2008, Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party., J. Clin. Oncol.
    Scharnhorst et al., 1997, Differential regulation of the Wilms' tumor gene, WT1, during differentiation of embryonal carcinoma and embryonic stem cells., Cell Growth Differ.
    Pinthus et al., 2005, Inhibition of Wilms tumor xenograft progression by halofuginone is accompanied by activation of WT-1 gene expression., J. Urol.
    Tirado et al., 2005, Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity., Oncogene
    Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.
    Wagner et al., 2003, Oxygen-regulated expression of the Wilms' tumor suppressor Wt1 involves hypoxia-inducible factor-1 (HIF-1)., FASEB J.
  • DIMETHYL SULFOXIDE   WT1

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9040935


    Sources:
    NCI

  • HALOFUGINONE   WT1

    Interaction Score: 2.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16148645


    Sources:
    NCI

  • DEFEROXAMINE   WT1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12738801


    Sources:
    NCI

  • CYTARABINE   WT1

    Interaction Score: 0.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18591546


    Sources:
    CIViC

  • SIROLIMUS   WT1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15782132


    Sources:
    NCI

  • DAUNORUBICIN   WT1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18591546


    Sources:
    CIViC

  • CURCUMIN   WT1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16490174


    Sources:
    NCI

  • Ensembl: ENSG00000184937

    • Version: 101_38

    Alternate Names:
    WT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • CIViC: WT1

    • Version: 14-September-2020

    Alternate Names:
    7490 Entrez Gene ID
    49 CIViC Gene ID

    Gene Info:

    Gene Categories:
    DRUG RESISTANCE

    Publications:
    Virappane et al., 2008, Mutation of the Wilms' tumor 1 gene is a poor prognostic factor associated with chemotherapy resistance in normal karyotype acute myeloid leukemia: the United Kingdom Medical Research Council Adult Leukaemia Working Party., J. Clin. Oncol.

  • NCI: WT1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Anuchapreeda et al., 2006, Curcumin inhibits WT1 gene expression in human leukemic K562 cells., Acta Pharmacol. Sin.
    Hernandez-Caballero et al., 2007, In vitro leukemic cell differentiation and WT1 gene expression., Leuk. Res.
    Maheswaran et al., 1998, Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70., Genes Dev.

  • HingoraniCasas: ENSG00000184937

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000184937 Gene Symbol
    WT1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: WT1

    • Version: 12-May-2016

    Alternate Names:
    WT1 Gene Symbol

    Gene Info:

    Publications:

  • Pharos: WT1

    • Version: 03-September-2020

    Alternate Names:
    Wilms tumor protein Gene Name
    P19544 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

  • Tempus: WT1

    • Version: 11-November-2018

    Alternate Names:
    WT1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: Wilms tumor protein

    • Version: 2020.06.01

    Alternate Names:
    WT1 TTD Gene Abbreviation
    T29960 TTD Target ID

    Gene Info:

    Publications:

  • MskImpact: WT1

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: WT1

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: WT1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21