DGIdb - WEE1 Gene Record

WEE1 7465 Druggable Genome

Alternate Names:

7465
WEE1 G2 CHECKPOINT KINASE
WEE1
WEE1A
WEE1hu
193525
12761
ENSG00000166483
OTTHUMG00000165863
P30291
WEE1-LIKE PROTEIN KINASE
WEE1A KINASE
6104
WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291]
T69991

Gene Info:

Initial Gene Query	Wee1
Counted Citations from 1950-2000	464
Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(12 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
TYROSINE KINASE
DRUGGABLE GENOME

Publications:

Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep
Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol
Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther
Hirai et al., 2009, Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents., Mol. Cancer Ther.
Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

CHEMBL592578 WEE1

Interaction Score: 6.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADAVOSERTIB WEE1

Interaction Score: 1.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor

Notes

PMIDs:
24305702 23270927 19887545

Sources:
TALC TdgClinicalTrial ChemblInteractions CIViC TTD
WITHAFERIN A WEE1

Interaction Score: 1.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24079846

Sources:
DTC
CHEMBL586135 WEE1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTOAPIGENONE WEE1

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL505670 WEE1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEMCITABINE WEE1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26057002

Sources:
CIViC
CHEMBL379975 WEE1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 WEE1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 WEE1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000166483
- Version: 101_38
Alternate Names:

WEE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000166483
- Version: 26-July-2011
Alternate Names:

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description

WEE1 Display Id

ENSG00000166483 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30291
- Version: January-2014
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:
BaderLabGenes: WEE1
- Version: February-2014
Alternate Names:

7465 Entrez Gene ID

Gene Info:

Initial Gene Query Wee1

Counted Citations from 1950-2000 464

Gene Categories:

KINASE

Publications:

CIViC: WEE1

Version: 14-September-2020

Alternate Names:

7465 Entrez Gene ID

6104 CIViC Gene ID

Gene Info:

Publications:

Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep

Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther

Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol

DTC: WEE1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
HingoraniCasas: ENSG00000166483
- Version: 31-May-2017
Alternate Names:

ENSG00000166483 Gene Symbol

WEE1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: WEE1
- Version: 12-May-2016
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: WEE1
- Version: chembl_23
Alternate Names:

WEE1hu UNIPROT

WEE1 GENE_SYMBOL

Wee1-like protein kinase UNIPROT

Gene Info:

Publications:
Tempus: WEE1
- Version: 11-November-2018
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: WEE1
- Version: 27-Jun-2013
Alternate Names:

7465 Gene ID

WEE1A dGene Synonym

WEE1hu dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:
TTD: Wee1-like protein kinase
- Version: 2020.06.01
Alternate Names:

WEE1 TTD Gene Abbreviation

T69991 TTD Target ID

Gene Info:

Publications:
Pharos: WEE1
- Version: 01-February-2022
Alternate Names:

Wee1-like protein kinase Gene Name

P30291 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
MyCancerGenomeClinicalTrial: WEE1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: WEE1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
GO: WEE1
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

TYROSINE KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase WEE1 inhibitor
Notes

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291]	Description
WEE1	Display Id
ENSG00000166483	Ensembl Gene Id

WEE1 Gene Record

WEE1 7465 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor Notes

PMIDs: 24305702 23270927 19887545

Sources: TALC TdgClinicalTrial ChemblInteractions CIViC TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24079846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26057002

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000166483

Alternate Names: WEE1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000166483

Alternate Names: WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description WEE1 Display Id ENSG00000166483 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P30291

Alternate Names: WEE1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.10.2

Publications:

BaderLabGenes: WEE1

Alternate Names: 7465 Entrez Gene ID

Gene Info: Initial Gene Query Wee1 Counted Citations from 1950-2000 464

Gene Categories: KINASE

Publications:

CIViC: WEE1

Alternate Names: 7465 Entrez Gene ID 6104 CIViC Gene ID

Gene Info:

DTC: WEE1

Alternate Names:

Gene Info:

Publications: Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

HingoraniCasas: ENSG00000166483

Alternate Names: ENSG00000166483 Gene Symbol WEE1 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

TALC: WEE1

Alternate Names: WEE1 Gene Symbol

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor

Notes

PMIDs:
24305702 23270927 19887545

Sources:
TALC TdgClinicalTrial ChemblInteractions CIViC TTD

Interaction Types & Directionality:

n/a

PMIDs:
24079846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26057002

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

WEE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description

WEE1 Display Id

ENSG00000166483 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

WEE1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Alternate Names:

7465 Entrez Gene ID

Gene Info:

Initial Gene Query Wee1

Counted Citations from 1950-2000 464

Gene Categories:

KINASE

Alternate Names:

7465 Entrez Gene ID

6104 CIViC Gene ID

Publications:

Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

Alternate Names:

ENSG00000166483 Gene Symbol

WEE1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

WEE1 Gene Symbol

Alternate Names:

WEE1hu UNIPROT

WEE1 GENE_SYMBOL

Wee1-like protein kinase UNIPROT

Alternate Names:

WEE1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

7465 Gene ID

WEE1A dGene Synonym

WEE1hu dGene Synonym

Gene Categories:

KINASE, SERINE THREONINE KINASE

Alternate Names:

WEE1 TTD Gene Abbreviation

T69991 TTD Target ID

Alternate Names:

Wee1-like protein kinase Gene Name

P30291 UniProt ID

Gene Categories:

KINASE

Gene Categories:

TYROSINE KINASE