DGIdb - WEE1 Gene Record

WEE1 7465 Druggable Genome

Alternate Names:

7465
WEE1 G2 CHECKPOINT KINASE
WEE1
WEE1A
WEE1hu
193525
12761
ENSG00000166483
OTTHUMG00000165863
P30291
2278
NP_003381
NM_003390
WEE1-LIKE PROTEIN KINASE
WEE1A KINASE
BE0003335
6104
WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291]
T69991

Gene Info:

Initial Gene Query	Wee1
Counted Citations from 1950-2000	464
GuideToPharmacology Gene Category Name	WEE family
GuideToPharmacology Gene Category ID	642
Target Class	Enzymes
Target Subclass	EC:2.7.10.2
Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(14 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
TYROSINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep
Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol
Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther
Hirai et al., 2009, Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents., Mol. Cancer Ther.
Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

CHEMBL512341 WEE1

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL462170 WEE1

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL214253 WEE1

Interaction Score: 8.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235

Sources:
DrugBank
CHEMBL592578 WEE1

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ADAVOSERTIB WEE1

Interaction Score: 1.4

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor

Notes

PMIDs:
24305702 23270927 19887545

Sources:
TALC DrugBank TdgClinicalTrial ChemblInteractions CIViC GuideToPharmacology TTD
WITHAFERIN A WEE1

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24079846

Sources:
DTC
CHEMBL586135 WEE1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PROTOAPIGENONE WEE1

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL505670 WEE1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GEMCITABINE WEE1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26057002

Sources:
CIViC
CHEMBL379975 WEE1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 WEE1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 WEE1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB WEE1

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000166483
- Version: 101_38
Alternate Names:

WEE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
RussLampel: ENSG00000166483
- Version: 26-July-2011
Alternate Names:

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description

WEE1 Display Id

ENSG00000166483 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
TdgClinicalTrial: P30291
- Version: January-2014
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Publications:
BaderLabGenes: WEE1
- Version: February-2014
Alternate Names:

7465 Entrez Gene ID

Gene Info:

Initial Gene Query Wee1

Counted Citations from 1950-2000 464

Gene Categories:

KINASE

Publications:
GuideToPharmacology: 7465
- Version: 29-September-2020
Alternate Names:

12761 HUGO Gene ID

12761 HUGO Gene Symbol

WEE1 G2 checkpoint kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name WEE family

GuideToPharmacology Gene Category ID 642

Gene Categories:

ENZYME

Publications:

CIViC: WEE1

Version: 14-September-2020

Alternate Names:

7465 Entrez Gene ID

6104 CIViC Gene ID

Gene Info:

Publications:

Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep

Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther

Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol

DrugBank: BE0003335

Version: 5.1.7

Alternate Names:

WEE1 DrugBank Gene Name

P30291 UniProt Accession

7465 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Hirai et al., 2009, Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents., Mol. Cancer Ther.

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DTC: WEE1
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
HingoraniCasas: ENSG00000166483
- Version: 31-May-2017
Alternate Names:

ENSG00000166483 Gene Symbol

WEE1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: WEE1
- Version: 12-May-2016
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: WEE1
- Version: chembl_23
Alternate Names:

WEE1hu UNIPROT

WEE1 GENE_SYMBOL

Wee1-like protein kinase UNIPROT

Gene Info:

Publications:
Pharos: WEE1
- Version: 03-September-2020
Alternate Names:

Wee1-like protein kinase Gene Name

P30291 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
Tempus: WEE1
- Version: 11-November-2018
Alternate Names:

WEE1 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
dGene: WEE1
- Version: 27-Jun-2013
Alternate Names:

7465 Gene ID

WEE1A dGene Synonym

WEE1hu dGene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE, KINASE

Publications:
TTD: Wee1-like protein kinase
- Version: 2020.06.01
Alternate Names:

WEE1 TTD Gene Abbreviation

T69991 TTD Target ID

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: WEE1
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: WEE1
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
GO: WEE1
- Version: 05-September-2020
Alternate Names:

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Serine/threonine-protein kinase WEE1 inhibitor
Notes

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291]	Description
WEE1	Display Id
ENSG00000166483	Ensembl Gene Id

12761	HUGO Gene ID
12761	HUGO Gene Symbol
WEE1 G2 checkpoint kinase	HUGO Gene Name

WEE1	DrugBank Gene Name
P30291	UniProt Accession
7465	Entrez Gene Id

WEE1 Gene Record

WEE1 7465 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor Notes

PMIDs: 24305702 23270927 19887545

Sources: TALC DrugBank TdgClinicalTrial ChemblInteractions CIViC GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24079846

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26057002

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26516587

Sources: DrugBank

Ensembl: ENSG00000166483

Alternate Names: WEE1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000166483

Alternate Names: WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description WEE1 Display Id ENSG00000166483 Ensembl Gene Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P30291

Alternate Names: WEE1 Gene Symbol

Gene Info: Target Class Enzymes Target Subclass EC:2.7.10.2

Publications:

BaderLabGenes: WEE1

Alternate Names: 7465 Entrez Gene ID

Gene Info: Initial Gene Query Wee1 Counted Citations from 1950-2000 464

Gene Categories: KINASE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor

Notes

PMIDs:
24305702 23270927 19887545

Sources:
TALC DrugBank TdgClinicalTrial ChemblInteractions CIViC GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
24079846

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26057002

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

WEE1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description

WEE1 Display Id

ENSG00000166483 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

WEE1 Gene Symbol

Gene Info:

Target Class Enzymes

Target Subclass EC:2.7.10.2

Alternate Names:

7465 Entrez Gene ID

Gene Info:

Initial Gene Query Wee1

Counted Citations from 1950-2000 464

Gene Categories:

KINASE

Alternate Names:

12761 HUGO Gene ID

12761 HUGO Gene Symbol

WEE1 G2 checkpoint kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name WEE family

GuideToPharmacology Gene Category ID 642

Gene Categories:

ENZYME

Alternate Names:

7465 Entrez Gene ID

6104 CIViC Gene ID

Alternate Names:

WEE1 DrugBank Gene Name

P30291 UniProt Accession

7465 Entrez Gene Id

Publications:

Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

Alternate Names:

ENSG00000166483 Gene Symbol

WEE1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

WEE1 Gene Symbol

Alternate Names:

WEE1hu UNIPROT

WEE1 GENE_SYMBOL

Wee1-like protein kinase UNIPROT

Alternate Names:

Wee1-like protein kinase Gene Name

P30291 UniProt ID

Gene Categories:

KINASE

Alternate Names:

WEE1 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

7465 Gene ID

WEE1A dGene Synonym

WEE1hu dGene Synonym

Gene Categories:

SERINE THREONINE KINASE, KINASE

Alternate Names:

WEE1 TTD Gene Abbreviation

T69991 TTD Target ID