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WEE1 Gene Record

  • Summary
  • Interactions
  • Claims
  • WEE1 7465 Druggable Genome

    Alternate Names:

    7465
    WEE1 G2 CHECKPOINT KINASE
    WEE1
    WEE1A
    WEE1hu
    193525
    12761
    ENSG00000166483
    OTTHUMG00000165863
    P30291
    WEE1-LIKE PROTEIN KINASE
    WEE1A KINASE
    6104
    WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291]
    T69991

    Gene Info:

    Initial Gene Query Wee1
    Counted Citations from 1950-2000 464
    Target Class Enzymes
    Target Subclass EC:2.7.10.2
    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    KINASE
    SERINE THREONINE KINASE
    TYROSINE KINASE
    DRUGGABLE GENOME

    Publications:

    Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep
    Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol
    Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther
    Hirai et al., 2009, Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents., Mol. Cancer Ther.
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod
  • CHEMBL592578   WEE1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ADAVOSERTIB   WEE1

    Interaction Score: 1.71

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Serine/threonine-protein kinase WEE1 inhibitor
    Notes

    PMIDs:
    24305702 23270927 19887545


    Sources:
    TALC TdgClinicalTrial ChemblInteractions CIViC TTD

  • WITHAFERIN A   WEE1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24079846


    Sources:
    DTC

  • CHEMBL586135   WEE1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PROTOAPIGENONE   WEE1

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL505670   WEE1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • GEMCITABINE   WEE1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26057002


    Sources:
    CIViC

  • CHEMBL379975   WEE1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • PD-0166285   WEE1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CYC-116   WEE1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • Ensembl: ENSG00000166483

    • Version: 101_38

    Alternate Names:
    WEE1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000166483

    • Version: 26-July-2011

    Alternate Names:
    WEE1-LIKE PROTEIN KINASE (EC 2.7.1.112) (WEE1HU). [SOURCE:UNIPROT/SWISSPROT;ACC:P30291] Description
    WEE1 Display Id
    ENSG00000166483 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30291

    • Version: January-2014

    Alternate Names:
    WEE1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.7.10.2

    Publications:

  • BaderLabGenes: WEE1

    • Version: February-2014

    Alternate Names:
    7465 Entrez Gene ID

    Gene Info:
    Initial Gene Query Wee1
    Counted Citations from 1950-2000 464

    Gene Categories:
    KINASE

    Publications:

  • CIViC: WEE1

    • Version: 14-September-2020

    Alternate Names:
    7465 Entrez Gene ID
    6104 CIViC Gene ID

    Gene Info:

    Publications:
    Liu et al., 2015, WEE1 kinase polymorphism as a predictive biomarker for efficacy of platinum-gemcitabine doublet chemotherapy in advanced non-small cell lung cancer patients., Sci Rep
    Caretti V et al., 2013, WEE1 kinase inhibition enhances the radiation response of diffuse intrinsic pontine gliomas., Mol Cancer Ther
    Mueller S et al., 2014, Targeting Wee1 for the treatment of pediatric high-grade gliomas., Neuro Oncol

  • DTC: WEE1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Roy RV et al., 2013, Withaferin A, a steroidal lactone from Withania somnifera, induces mitotic catastrophe and growth arrest in prostate cancer cells., J Nat Prod

  • HingoraniCasas: ENSG00000166483

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000166483 Gene Symbol
    WEE1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: WEE1

    • Version: 12-May-2016

    Alternate Names:
    WEE1 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: WEE1

    • Version: chembl_23

    Alternate Names:
    WEE1hu UNIPROT
    WEE1 GENE_SYMBOL
    Wee1-like protein kinase UNIPROT

    Gene Info:

    Publications:

  • Tempus: WEE1

    • Version: 11-November-2018

    Alternate Names:
    WEE1 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • dGene: WEE1

    • Version: 27-Jun-2013

    Alternate Names:
    7465 Gene ID
    WEE1A dGene Synonym
    WEE1hu dGene Synonym

    Gene Info:

    Gene Categories:
    KINASE, SERINE THREONINE KINASE

    Publications:

  • TTD: Wee1-like protein kinase

    • Version: 2020.06.01

    Alternate Names:
    WEE1 TTD Gene Abbreviation
    T69991 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: WEE1

    • Version: 01-February-2022

    Alternate Names:
    Wee1-like protein kinase Gene Name
    P30291 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MyCancerGenomeClinicalTrial: WEE1

    • Version: 30-February-2014

    Alternate Names:

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: WEE1

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • GO: WEE1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    TYROSINE KINASE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21