DGIdb - VEGFB Gene Record

VEGFB 7423 Druggable GenomeClinically Actionable

Alternate Names:

7423
VASCULAR ENDOTHELIAL GROWTH FACTOR B
VEGFB
VEGFL
VRF
601398
12681
ENSG00000173511
OTTHUMG00000167813
P49765
VEGF-related factor
VEGF-B
PA37303
T30040

Gene Info:

Target Class	Ligand
Target Subclass	Ligand
Target Subclass	Growth factor
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

GROWTH FACTOR
DRUGGABLE GENOME
CLINICALLY ACTIONABLE

Publications:

Browning et al., 2012, Aflibercept for age-related macular degeneration: a game-changer or quiet addition?, Am. J. Ophthalmol.
Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

AFLIBERCEPT VEGFB

Interaction Score: 15.46

Interaction Types & Directionality:

antibody (inhibitory)

binder

Interaction Info:

PMIDs:
22813448 20124951

Sources:
MyCancerGenome PharmGKB TTD
CONBERCEPT VEGFB

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor B inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
BEVACIZUMAB VEGFB

Interaction Score: 1.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20124951

Sources:
ClearityFoundationClinicalTrial PharmGKB
LENALIDOMIDE VEGFB

Interaction Score: 1.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Ensembl: ENSG00000173511
- Version: 101_38
Alternate Names:

VEGFB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: P49765
- Version: January-2014
Alternate Names:

VEGFB Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass Growth factor

Publications:
PharmGKB: VEGFB
- Version: 18-August-2020
Alternate Names:

PA37303 PharmGKB ID

Gene Info:

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics
MyCancerGenome: VEGFB
- Version: 20-Jun-2017
Alternate Names:

7423 Entrez Gene Id

VEGFB MyCancerGenome Gene Symbol

VEGFB MyCancerGenome Reported Gene Name

Gene Info:

Publications:
ChemblInteractions: VRF
- Version: chembl_23
Alternate Names:

VRF GENE_SYMBOL

VEGFB GENE_SYMBOL

Vascular endothelial growth factor B UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000173511
- Version: 31-May-2017
Alternate Names:

ENSG00000173511 Gene Symbol

VEGFB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: VEGFB
- Version: 01-February-2022
Alternate Names:

VRF GO Gene Synonym

Gene Info:

Gene Categories:

GROWTH FACTOR

Publications:
TTD: Vascular endothelial growth factor B
- Version: 2020.06.01
Alternate Names:

VEGFB TTD Gene Abbreviation

T30040 TTD Target ID

Gene Info:

Publications:
MyCancerGenomeClinicalTrial: VEGFB
- Version: 30-February-2014
Alternate Names:

Gene Info:

Publications:
ClearityFoundationClinicalTrial: VEGFB
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
CarisMolecularIntelligence: VEGFB
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction	yes
Mechanism of Interaction	Vascular endothelial growth factor B inhibitor

7423	Entrez Gene Id
VEGFB	MyCancerGenome Gene Symbol
VEGFB	MyCancerGenome Reported Gene Name

VRF	GENE_SYMBOL
VEGFB	GENE_SYMBOL
Vascular endothelial growth factor B	UNIPROT

antibody (inhibitory)
binder

VEGFB Gene Record

VEGFB 7423 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

AFLIBERCEPT VEGFB

Interaction Types & Directionality: antibody (inhibitory) binder

Interaction Info:

PMIDs: 22813448 20124951

Sources: MyCancerGenome PharmGKB TTD

CONBERCEPT VEGFB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor B inhibitor

PMIDs: None found

Sources: ChemblInteractions

BEVACIZUMAB VEGFB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20124951

Sources: ClearityFoundationClinicalTrial PharmGKB

LENALIDOMIDE VEGFB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Ensembl: ENSG00000173511

Alternate Names: VEGFB Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: P49765

Alternate Names: VEGFB Gene Symbol

Gene Info: Target Class Ligand Target Subclass Ligand Target Subclass Growth factor

Publications:

PharmGKB: VEGFB

Alternate Names: PA37303 PharmGKB ID

Gene Info:

Publications: Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

MyCancerGenome: VEGFB

Alternate Names: 7423 Entrez Gene Id VEGFB MyCancerGenome Gene Symbol VEGFB MyCancerGenome Reported Gene Name

Gene Info:

Publications:

ChemblInteractions: VRF

Alternate Names: VRF GENE_SYMBOL VEGFB GENE_SYMBOL Vascular endothelial growth factor B UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000173511

Alternate Names: ENSG00000173511 Gene Symbol VEGFB Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

GO: VEGFB

Alternate Names: VRF GO Gene Synonym

Gene Info:

Gene Categories: GROWTH FACTOR

Publications:

TTD: Vascular endothelial growth factor B

Alternate Names: VEGFB TTD Gene Abbreviation T30040 TTD Target ID

Gene Info:

Publications:

MyCancerGenomeClinicalTrial: VEGFB

Alternate Names:

Gene Info:

Publications:

ClearityFoundationClinicalTrial: VEGFB

Alternate Names:

Gene Info:

Publications:

CarisMolecularIntelligence: VEGFB

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

antibody (inhibitory)

binder

PMIDs:
22813448 20124951

Sources:
MyCancerGenome PharmGKB TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor B inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20124951

Sources:
ClearityFoundationClinicalTrial PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Alternate Names:

VEGFB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

VEGFB Gene Symbol

Gene Info:

Target Class Ligand

Target Subclass Ligand

Target Subclass Growth factor

Alternate Names:

PA37303 PharmGKB ID

Publications:

Maitland ML et al., 2010, Vascular endothelial growth factor pathway., Pharmacogenet Genomics

Alternate Names:

7423 Entrez Gene Id

VEGFB MyCancerGenome Gene Symbol

VEGFB MyCancerGenome Reported Gene Name

Alternate Names:

VRF GENE_SYMBOL

VEGFB GENE_SYMBOL

Vascular endothelial growth factor B UNIPROT

Alternate Names:

ENSG00000173511 Gene Symbol

VEGFB Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

VRF GO Gene Synonym

Gene Categories:

GROWTH FACTOR

Alternate Names:

VEGFB TTD Gene Abbreviation

T30040 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE