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UGT1A9 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A9 54600 Druggable Genome

    Alternate Names:

    54600
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A9
    UGT1A9
    HLUGP4
    LUGP4
    UDPGT
    UDPGT 1-9
    UGT-1I
    UGT1-09
    UGT1-9
    UGT1.9
    UGT1A9S
    UGT1AI
    UGT1I
    606434
    12541
    ENSG00000241119
    OTTHUMG00000059124
    PA419
    UDP-glucuronosyltransferase 1-9
    O60656

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Wang H et al., 2014, Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers., Pharmacogenomics
    Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer
    Han JY et al., 2006, Comprehensive analysis of UGT1A polymorphisms predictive for pharmacokinetics and treatment outcome in patients with non-small-cell lung cancer treated with irinotecan and cisplatin., J Clin Oncol
    Gagné JF et al., 2002, Common human UGT1A polymorphisms and the altered metabolism of irinotecan active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38)., Mol Pharmacol
    Iwuchukwu OF et al., 2014, Genetic variation in the UGT1A locus is associated with simvastatin efficacy in a clinical practice setting., Pharmacogenomics
    Gong L et al., 2017, PharmGKB summary: sorafenib pathways., Pharmacogenet Genomics
    Boudou-Rouquette P et al., 2012, Early sorafenib-induced toxicity is associated with drug exposure and UGTIA9 genetic polymorphism in patients with solid tumors: a preliminary study., PLoS One
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    Nakagawa T et al., 2012, Acetaminophen administration in a patient with Gilbert's syndrome., Pediatr Int
    Mutlib AE et al., 2006, Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity., Chem Res Toxicol
    Court MH et al., 2001, Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms., J Pharmacol Exp Ther
    Korprasertthaworn P et al., 2012, Effects of amino acid substitutions at positions 33 and 37 on UDP-glucuronosyltransferase 1A9 (UGT1A9) activity and substrate selectivity., Biochem Pharmacol
    Lu Y et al., 2017, Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy., Eur J Clin Pharmacol
    Mazaleuskaya LL et al., 2015, PharmGKB summary: ibuprofen pathways., Pharmacogenet Genomics
    Takahashi H et al., 2008, Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)., Basic Clin Pharmacol Toxicol
    Lévesque E et al., 2013, Refining the UGT1A haplotype associated with irinotecan-induced hematological toxicity in metastatic colorectal cancer patients treated with 5-fluorouracil/irinotecan-based regimens., J Pharmacol Exp Ther
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
  • RALTEGRAVIR   UGT1A9

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   UGT1A9

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24897286 18221820 16636344 12181437


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A9

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • SULFINPYRAZONE   UGT1A9

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22981363


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT1A9

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23279026 16696573 11714888


    Sources:
    PharmGKB

  • OXCARBAZEPINE   UGT1A9

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27900402


    Sources:
    PharmGKB

  • IRINOTECAN   UGT1A9

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23386248 18221820 16636344 12181437


    Sources:
    PharmGKB

  • ALLOPURINOL   UGT1A9

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • PROPOFOL   UGT1A9

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18816295


    Sources:
    PharmGKB

  • IBUPROFEN   UGT1A9

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25502615


    Sources:
    PharmGKB

  • PHENOBARBITAL   UGT1A9

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • PHENYTOIN   UGT1A9

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • OXAZEPAM   UGT1A9

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SORAFENIB   UGT1A9

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28362716 22912756


    Sources:
    PharmGKB

  • SIMVASTATIN   UGT1A9

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25493567


    Sources:
    PharmGKB

  • METHOTREXATE   UGT1A9

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A9

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000241119

    • Version: 101_38

    Alternate Names:
    UGT1A9 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A9

    • Version: 18-August-2020

    Alternate Names:
    PA419 PharmGKB ID

    Gene Info:

    Publications:
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    Takahashi H et al., 2008, Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)., Basic Clin Pharmacol Toxicol
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

  • NCI: UGT1A9

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Shamaan et al., Vitamin C and aloe vera supplementation protects from chemical hepatocarcinogenesis in the rat., Nutrition

  • HingoraniCasas: ENSG00000241119

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000241119 Gene Symbol
    UGT1A9 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Tempus: UGT1A9

    • Version: 11-November-2018

    Alternate Names:
    UGT1A9 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: UGT1A9

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-9 Gene Name
    O60656 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21