• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

UGT1A7 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A7 54577 Druggable Genome

    Alternate Names:

    54577
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A7
    UGT1A7
    UDPGT
    UDPGT 1-7
    UGT-1G
    UGT1-07
    UGT1.7
    UGT1G
    606432
    12539
    ENSG00000244122
    OTTHUMG00000059004
    UGT1
    GNT1
    PA37182
    UGT-1A
    UGT1-01
    UGT1.1
    UGT1A
    UGT1A1
    hUG-BR1
    UDP-glucuronosyltransferase 1-7
    Q9HAW7

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Ghosheh et al., 2002, N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases., Drug Metab. Dispos.
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    Lankisch TO et al., 2006, Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype., Hepatology
    Lu Y et al., 2017, Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy., Eur J Clin Pharmacol
    Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.
  • ATAZANAVIR   UGT1A7

    Interaction Score: 1.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17058217


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A7

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • RITONAVIR   UGT1A7

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17058217


    Sources:
    PharmGKB

  • OXCARBAZEPINE   UGT1A7

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27900402


    Sources:
    PharmGKB

  • ALLOPURINOL   UGT1A7

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • NICOTINE   UGT1A7

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12167564


    Sources:
    NCI

  • CURCUMIN   UGT1A7

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15845768


    Sources:
    NCI

  • METHOTREXATE   UGT1A7

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A7

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000244122

    • Version: 101_38

    Alternate Names:
    UGT1A7 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A7

    • Version: 18-August-2020

    Alternate Names:
    PA37182 PharmGKB ID

    Gene Info:

    Publications:
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Lankisch TO et al., 2006, Gilbert's disease and atazanavir: from phenotype to UDP-glucuronosyltransferase haplotype., Hepatology
    Lamba V et al., 2014, PharmGKB summary: mycophenolic acid pathway., Pharmacogenet Genomics

  • NCI: UGT1A7

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ghosheh et al., 2002, N-glucuronidation of nicotine and cotinine in human: formation of cotinine glucuronide in liver microsomes and lack of catalysis by 10 examined UDP-glucuronosyltransferases., Drug Metab. Dispos.
    Basu et al., 2005, Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity., Proc. Natl. Acad. Sci. U.S.A.

  • HingoraniCasas: ENSG00000244122

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000244122 Gene Symbol
    UGT1A7 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: UGT1A7

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-7 Gene Name
    Q9HAW7 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21