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UGT1A6 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A6 54578 Druggable Genome

    Alternate Names:

    54578
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A6
    UGT1A6
    GNT1
    HLUGP
    HLUGP1
    UDPGT
    UDPGT 1-6
    UGT1
    UGT1A6S
    UGT1F
    606431
    12538
    ENSG00000167165
    OTTHUMG00000059122
    PA37181
    UGT-1A
    UGT-1C
    UGT-1E
    UGT-1F
    UGT1-01
    UGT1-03
    UGT1-05
    UGT1-06
    UGT1.1
    UGT1.3
    UGT1.5
    UGT1.6
    UGT1A
    UGT1A1
    UGT1A3
    UGT1A5
    UGT1C
    UGT1E
    hUG-BR1
    P19224
    UDP-glucuronosyltransferase 1-6

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Mazaleuskaya LL et al., 2015, PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses., Pharmacogenet Genomics
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    McGill MR et al., 2013, Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis., Pharm Res
    Nakagawa T et al., 2012, Acetaminophen administration in a patient with Gilbert's syndrome., Pediatr Int
    Tankanitlert J et al., 2007, Effects of combined UDP-glucuronosyltransferase (UGT) 1A1*28 and 1A6*2 on paracetamol pharmacokinetics in beta-thalassemia/HbE., Pharmacology
    Mutlib AE et al., 2006, Kinetics of acetaminophen glucuronidation by UDP-glucuronosyltransferases 1A1, 1A6, 1A9 and 2B15. Potential implications in acetaminophen-induced hepatotoxicity., Chem Res Toxicol
    Krishnaswamy S et al., 2005, UDP glucuronosyltransferase (UGT) 1A6 pharmacogenetics: II. Functional impact of the three most common nonsynonymous UGT1A6 polymorphisms (S7A, T181A, and R184S)., J Pharmacol Exp Ther
    Court MH et al., 2001, Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms., J Pharmacol Exp Ther
    Kretz-Rommel et al., 1993, Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes., Toxicol. Appl. Pharmacol.
    Dadheech S et al., 2013, Three most common nonsynonymous UGT1A6*2 polymorphisms (Thr181Ala, Arg184Ser and Ser7Ala) and therapeutic response to deferiprone in β-thalassemia major patients., Gene
  • DEFERIPRONE   UGT1A6

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24036429


    Sources:
    PharmGKB

  • ACETAMINOPHEN   UGT1A6

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587 23462933 23279026 17164591 16696573 15761113 11714888


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A6

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • DICLOFENAC   UGT1A6

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8511777


    Sources:
    NCI

  • ALLOPURINOL   UGT1A6

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • PHENOBARBITAL   UGT1A6

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • PHENYTOIN   UGT1A6

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26049587


    Sources:
    PharmGKB

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   UGT1A6

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHOTREXATE   UGT1A6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A6

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DAUNORUBICIN   UGT1A6

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ASPIRIN   UGT1A6

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DOXORUBICIN   UGT1A6

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000167165

    • Version: 101_38

    Alternate Names:
    UGT1A6 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A6

    • Version: 18-August-2020

    Alternate Names:
    PA37181 PharmGKB ID

    Gene Info:

    Publications:
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Visscher H et al., 2013, Validation of variants in SLC28A3 and UGT1A6 as genetic markers predictive of anthracycline-induced cardiotoxicity in children., Pediatr Blood Cancer
    Visscher H et al., 2012, Pharmacogenomic prediction of anthracycline-induced cardiotoxicity in children., J Clin Oncol

  • NCI: UGT1A6

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kretz-Rommel et al., 1993, Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes., Toxicol. Appl. Pharmacol.

  • HingoraniCasas: ENSG00000167165

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000167165 Gene Symbol
    UGT1A6 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: UGT1A6

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-6 Gene Name
    P19224 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21