• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

UGT1A5 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A5 54579 Druggable Genome

    Alternate Names:

    54579
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A5
    UGT1A5
    UDPGT
    UDPGT 1-5
    UGT1E
    606430
    12537
    ENSG00000240224
    OTTHUMG00000059120
    PA37180
    ENSG00000288705
    P35504
    UDP-glucuronosyltransferase 1-5

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
    Mori et al., 2003, Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver., Mutagenesis
    Mori et al., 2002, Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver., Mutagenesis
    Nakaoka, 1990, Kinetic characteristics of UDP-glucuronosyltransferases towards a dithiol metabolite of malotilate in hepatic microsomes of rats and rabbits., Xenobiotica
    Burchell et al., 1990, The role of xenobiotic glucuronidating enzymes in drug resistance of tumour tissues and cells., Int. Symp. Princess Takamatsu Cancer Res. Fund
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
  • ESTRONE   UGT1A5

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6138227


    Sources:
    NCI

  • FEBUXOSTAT   UGT1A5

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • TESTOSTERONE   UGT1A5

    Interaction Score: 0.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6138227 12473741 11971997


    Sources:
    NCI

  • ADRIAMYCIN   UGT1A5

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1966888


    Sources:
    NCI

  • ALLOPURINOL   UGT1A5

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • PHENOBARBITAL   UGT1A5

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2120856


    Sources:
    NCI

  • MITOXANTRONE   UGT1A5

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1966888


    Sources:
    NCI

  • METHOTREXATE   UGT1A5

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000240224

    • Version: 101_38

    Alternate Names:
    UGT1A5 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A5

    • Version: 18-August-2020

    Alternate Names:
    PA37180 PharmGKB ID

    Gene Info:

    Publications:
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    Mei S et al., 2017, Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy., Seizure

  • NCI: UGT1A5

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Burchell et al., 1990, The role of xenobiotic glucuronidating enzymes in drug resistance of tumour tissues and cells., Int. Symp. Princess Takamatsu Cancer Res. Fund
    Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
    Mori et al., 2003, Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver., Mutagenesis

  • HingoraniCasas: ENSG00000240224

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000240224 Gene Symbol
    UGT1A5 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: UGT1A5

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-5 Gene Name
    P35504 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21