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UGT1A4 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A4 54657 Druggable Genome

    Alternate Names:

    54657
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A4
    UGT1A4
    HUG-BR2
    UDPGT
    UDPGT 1-4
    UGT-1D
    UGT1-04
    UGT1.4
    UGT1A4S
    UGT1D
    606429
    12536
    ENSG00000244474
    OTTHUMG00000059119
    PA37179
    P22310
    GNT1
    UGT-1A
    UGT1
    UGT1-01
    UGT1.1
    UGT1A
    UGT1A1
    hUG-BR1
    UDP-glucuronosyltransferase 1-4

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Kuehl et al., 2003, N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases., Drug Metab. Dispos.
    Innocenti F et al., 2013, Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751., Pharmacogenet Genomics
    Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
    Edavana VK et al., 2013, Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics., Drug Metab Dispos
    Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.
    Zucker et al., 1999, Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation., Ther Drug Monit
    Klarica Domjanović I et al., 2018, Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy., Br J Clin Pharmacol
    Inoue K et al., 2016, Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy., Eur J Clin Pharmacol
    Chang Y et al., 2014, Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China., Eur J Clin Pharmacol
    Singkham N et al., 2013, Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients., Eur J Clin Pharmacol
    Zhou J et al., 2011, Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes., Pharmacogenomics
    Chaudhary et al., 1993, Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways., J. Pharmacol. Exp. Ther.
    Tavoloni et al., 1983, Dose-related effects of phenobarbital on hepatic microsomal enzymes., Proc. Soc. Exp. Biol. Med.
  • LAMOTRIGINE   UGT1A4

    Interaction Score: 1.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791014 26790665 24820767 23263737 22047493


    Sources:
    PharmGKB

  • FEBUXOSTAT   UGT1A4

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • ANASTROZOLE   UGT1A4

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23371966


    Sources:
    PharmGKB

  • ABT-751   UGT1A4

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23670235


    Sources:
    PharmGKB

  • PHENOBARBITAL   UGT1A4

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8510012 6314341


    Sources:
    NCI

  • ALLOPURINOL   UGT1A4

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • TACROLIMUS   UGT1A4

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10051052


    Sources:
    NCI

  • ACETAMINOPHEN   UGT1A4

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2903022


    Sources:
    NCI

  • NICOTINE   UGT1A4

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14570768


    Sources:
    NCI

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   UGT1A4

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • MIDAZOLAM   UGT1A4

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ALCOHOL   UGT1A4

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2502039


    Sources:
    NCI

  • METHOTREXATE   UGT1A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000244474

    • Version: 101_38

    Alternate Names:
    UGT1A4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A4

    • Version: 18-August-2020

    Alternate Names:
    PA37179 PharmGKB ID

    Gene Info:

    Publications:
    Sutiman N et al., 2016, Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients., Clin Pharmacokinet
    Erickson-Ridout KK et al., 2012, Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A(TA)₇TAA and UGT1A4 L48V polymorphisms., Pharmacogenet Genomics
    Wang Z et al., 2014, Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability., Endocrinology

  • NCI: UGT1A4

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Sardar et al., 1996, Role of vitamin D3 on the activity patterns of hepatic drug metabolizing enzymes in transplantable murine lymphoma., Cancer Invest.
    Thunberg et al., 1984, Comparison between the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and six other compounds on the vitamin A storage, the UDP-glucuronosyltransferase and the aryl hydrocarbon hydroxylase activity in the rat liver., Arch. Toxicol.
    Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.

  • HingoraniCasas: ENSG00000244474

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000244474 Gene Symbol
    UGT1A4 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: UGT1A4

    • Version: 19.3

    Alternate Names:
    ENSG00000244474 Ensembl Gene ID
    HUG-BR2 Human Protein Atlas Gene Synonym
    UGT1D Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Pharos: UGT1A4

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-4 Gene Name
    P22310 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21