DGIdb - UGT1A4 Gene Record

UGT1A4 54657 Druggable Genome

Alternate Names:

54657
UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A4
UGT1A4
HUG-BR2
UDPGT
UDPGT 1-4
UGT-1D
UGT1-04
UGT1.4
UGT1A4S
UGT1D
606429
12536
ENSG00000244474
OTTHUMG00000059119
PA37179
UDP glucuronosyltransferase 1 family, polypeptide A4
P22310
UDP-glucuronosyltransferase 1-4
GNT1
UGT-1A
UGT1
UGT1-01
UGT1.1
UGT1A
UGT1A1
hUG-BR1

Gene Info:

Has Variant Annotation	true
Is VIP	false
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kuehl et al., 2003, N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases., Drug Metab. Dispos.
Innocenti F et al., 2013, Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751., Pharmacogenet Genomics
Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.
Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
Edavana VK et al., 2013, Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics., Drug Metab Dispos
Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.
Zucker et al., 1999, Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation., Ther Drug Monit
Klarica Domjanović I et al., 2018, Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy., Br J Clin Pharmacol
Inoue K et al., 2016, Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy., Eur J Clin Pharmacol
Chang Y et al., 2014, Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China., Eur J Clin Pharmacol
Singkham N et al., 2013, Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients., Eur J Clin Pharmacol
Zhou J et al., 2011, Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes., Pharmacogenomics
Chaudhary et al., 1993, Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways., J. Pharmacol. Exp. Ther.
Tavoloni et al., 1983, Dose-related effects of phenobarbital on hepatic microsomal enzymes., Proc. Soc. Exp. Biol. Med.

NICOTINE UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Kuehl et al., 2003, N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases., Drug Metab. Dispos.

ABT-751 UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Innocenti F et al., 2013, Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751., Pharmacogenet Genomics

ALCOHOL UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.
FEBUXOSTAT UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
METHOTREXATE UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
ANASTROZOLE UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Edavana VK et al., 2013, Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics., Drug Metab Dispos
ACETAMINOPHEN UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.
TACROLIMUS UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Zucker et al., 1999, Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation., Ther Drug Monit
ALLOPURINOL UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

LAMOTRIGINE UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Klarica Domjanović I et al., 2018, Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy., Br J Clin Pharmacol

Inoue K et al., 2016, Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy., Eur J Clin Pharmacol

Chang Y et al., 2014, Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China., Eur J Clin Pharmacol

PHENOBARBITAL UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chaudhary et al., 1993, Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways., J. Pharmacol. Exp. Ther.

Tavoloni et al., 1983, Dose-related effects of phenobarbital on hepatic microsomal enzymes., Proc. Soc. Exp. Biol. Med.

7-ETHYL-10-HYDROXYCAMPTOTHECIN UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
MIDAZOLAM UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
RISPERIDONE UGT1A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Ensembl: ENSG00000244474
- Version: 101_38
Alternate Names:

UGT1A4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: UGT1A4

Version: 18-August-2020

Alternate Names:

PA37179 PharmGKB ID

Gene Info:

Publications:

Sutiman N et al., 2016, Pharmacogenetics of UGT1A4, UGT2B7 and UGT2B15 and Their Influence on Tamoxifen Disposition in Asian Breast Cancer Patients., Clin Pharmacokinet

Erickson-Ridout KK et al., 2012, Glucuronidation of the second-generation antipsychotic clozapine and its active metabolite N-desmethylclozapine. Potential importance of the UGT1A1 A(TA)₇TAA and UGT1A4 L48V polymorphisms., Pharmacogenet Genomics

Wang Z et al., 2014, Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability., Endocrinology

NCI: UGT1A4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Sardar et al., 1996, Role of vitamin D3 on the activity patterns of hepatic drug metabolizing enzymes in transplantable murine lymphoma., Cancer Invest.

Thunberg et al., 1984, Comparison between the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and six other compounds on the vitamin A storage, the UDP-glucuronosyltransferase and the aryl hydrocarbon hydroxylase activity in the rat liver., Arch. Toxicol.

Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.

HingoraniCasas: ENSG00000244474
- Version: 31-May-2017
Alternate Names:

ENSG00000244474 Gene Symbol

UGT1A4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: UGT1A4
- Version: 19.3
Alternate Names:

ENSG00000244474 Ensembl Gene ID

HUG-BR2 Human Protein Atlas Gene Synonym

UGT1D Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories:

ENZYME

Publications:
Pharos: UGT1A4
- Version: 03-September-2020
Alternate Names:

UDP-glucuronosyltransferase 1-4 Gene Name

P22310 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:

ENSG00000244474	Ensembl Gene ID
HUG-BR2	Human Protein Atlas Gene Synonym
UGT1D	Human Protein Atlas Gene Synonym

UGT1A4 Gene Record

UGT1A4 54657 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Kuehl et al., 2003, N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases., Drug Metab. Dispos.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Innocenti F et al., 2013, Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751., Pharmacogenet Genomics

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Edavana VK et al., 2013, Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics., Drug Metab Dispos

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Zucker et al., 1999, Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation., Ther Drug Monit

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chaudhary et al., 1993, Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways., J. Pharmacol. Exp. Ther. Tavoloni et al., 1983, Dose-related effects of phenobarbital on hepatic microsomal enzymes., Proc. Soc. Exp. Biol. Med.

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Ensembl: ENSG00000244474

Alternate Names: UGT1A4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: UGT1A4

Alternate Names: PA37179 PharmGKB ID

Gene Info:

NCI: UGT1A4

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000244474

Alternate Names: ENSG00000244474 Gene Symbol UGT1A4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: UGT1A4

Alternate Names: ENSG00000244474 Ensembl Gene ID HUG-BR2 Human Protein Atlas Gene Synonym UGT1D Human Protein Atlas Gene Synonym

Gene Info:

Gene Categories: ENZYME

Publications:

Pharos: UGT1A4

Alternate Names: UDP-glucuronosyltransferase 1-4 Gene Name P22310 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Interaction Types & Directionality:

n/a

Publications:

Kuehl et al., 2003, N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases., Drug Metab. Dispos.

Interaction Types & Directionality:

n/a

Publications:

Innocenti F et al., 2013, Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751., Pharmacogenet Genomics

Interaction Types & Directionality:

n/a

Publications:

Farinati et al., 1989, Effects of chronic ethanol consumption on carcinogen activating and detoxifying systems in rat upper alimentary tract tissue., Alcohol. Clin. Exp. Res.

Interaction Types & Directionality:

n/a

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

Interaction Types & Directionality:

n/a

Publications:

Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol

Interaction Types & Directionality:

n/a

Publications:

Edavana VK et al., 2013, Potential role of UGT1A4 promoter SNPs in anastrozole pharmacogenomics., Drug Metab Dispos

Interaction Types & Directionality:

n/a

Publications:

Neumann et al., Ascorbic acid deficiency and hepatic UDP-glucuronyltransferase., Drug Metab. Dispos.

Interaction Types & Directionality:

n/a

Publications:

Zucker et al., 1999, Evidence that tacrolimus augments the bioavailability of mycophenolate mofetil through the inhibition of mycophenolic acid glucuronidation., Ther Drug Monit

Interaction Types & Directionality:

n/a

Publications:

Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Publications:

Chaudhary et al., 1993, Effect of genetic obesity and phenobarbital treatment on the hepatic conjugation pathways., J. Pharmacol. Exp. Ther.

Tavoloni et al., 1983, Dose-related effects of phenobarbital on hepatic microsomal enzymes., Proc. Soc. Exp. Biol. Med.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

UGT1A4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA37179 PharmGKB ID

Alternate Names:

ENSG00000244474 Gene Symbol

UGT1A4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000244474 Ensembl Gene ID

HUG-BR2 Human Protein Atlas Gene Synonym

UGT1D Human Protein Atlas Gene Synonym

Gene Categories:

ENZYME

Alternate Names:

UDP-glucuronosyltransferase 1-4 Gene Name

P22310 UniProt ID

Gene Categories:

ENZYME