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UGT1A10 Gene Record

  • Summary
  • Interactions
  • Claims
  • UGT1A10 54575 Druggable Genome

    Alternate Names:

    54575
    UDP GLUCURONOSYLTRANSFERASE FAMILY 1 MEMBER A10
    UGT1A10
    UDPGT
    UGT-1J
    UGT1-10
    UGT1.10
    UGT1J
    606435
    12531
    ENSG00000242515
    OTTHUMG00000059121
    PA37174
    GNT1
    UGT-1A
    UGT1
    UGT1-01
    UGT1.1
    UGT1A
    UGT1A1
    hUG-BR1
    UDP-glucuronosyltransferase 1-10
    Q9HAW8

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Lu Y et al., 2017, Effects of UGT1A9 genetic polymorphisms on monohydroxylated derivative of oxcarbazepine concentrations and oxcarbazepine monotherapeutic efficacy in Chinese patients with epilepsy., Eur J Clin Pharmacol
    Carroll MB et al., 2017, Genomic sequencing of uric acid metabolizing and clearing genes in relationship to xanthine oxidase inhibitor dose., Rheumatol Int
    Watanabe et al., 2003, Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1., Drug Metab. Dispos.
    Watanabe et al., 2002, Troglitazone glucuronidation in human liver and intestine microsomes: high catalytic activity of UGT1A8 and UGT1A10., Drug Metab. Dispos.
    Horio et al., 1993, UDP glucuronosyltransferase gene expression is involved in the stimulation of ascorbic acid biosynthesis by xenobiotics in rats., J. Nutr.
    Kretz-Rommel et al., 1993, Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes., Toxicol. Appl. Pharmacol.
    Lui G et al., 2018, A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High-Dose Methotrexate: Data From the OS2006/Sarcoma-09 Trial., J Clin Pharmacol
  • FEBUXOSTAT   UGT1A10

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • OXCARBAZEPINE   UGT1A10

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27900402


    Sources:
    PharmGKB

  • DICLOFENAC   UGT1A10

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8511777


    Sources:
    NCI

  • TROGLITAZONE   UGT1A10

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12433820


    Sources:
    NCI

  • ALLOPURINOL   UGT1A10

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27798726


    Sources:
    PharmGKB

  • PHENOBARBITAL   UGT1A10

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8263600


    Sources:
    NCI

  • ETOPOSIDE   UGT1A10

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12695347


    Sources:
    NCI

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   UGT1A10

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • METHOTREXATE   UGT1A10

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29791011


    Sources:
    PharmGKB

  • RISPERIDONE   UGT1A10

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000242515

    • Version: 101_38

    Alternate Names:
    UGT1A10 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: UGT1A10

    • Version: 18-August-2020

    Alternate Names:
    PA37174 PharmGKB ID

    Gene Info:

    Publications:
    Lamba V et al., 2014, PharmGKB summary: mycophenolic acid pathway., Pharmacogenet Genomics
    Hung CC et al., 2011, Association of genetic variants in six candidate genes with valproic acid therapy optimization., Pharmacogenomics
    Mei S et al., 2017, Genetic polymorphisms and valproic acid plasma concentration in children with epilepsy on valproic acid monotherapy., Seizure

  • NCI: UGT1A10

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kretz-Rommel et al., 1993, Diclofenac covalent protein binding is dependent on acyl glucuronide formation and is inversely related to P450-mediated acute cell injury in cultured rat hepatocytes., Toxicol. Appl. Pharmacol.
    Sardar et al., 1996, Role of vitamin D3 on the activity patterns of hepatic drug metabolizing enzymes in transplantable murine lymphoma., Cancer Invest.
    Watanabe et al., 2003, Glucuronidation of etoposide in human liver microsomes is specifically catalyzed by UDP-glucuronosyltransferase 1A1., Drug Metab. Dispos.

  • HingoraniCasas: ENSG00000242515

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000242515 Gene Symbol
    UGT1A10 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: UGT1A10

    • Version: 01-February-2022

    Alternate Names:
    UDP-glucuronosyltransferase 1-10 Gene Name
    Q9HAW8 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21