DGIdb - TUBB Gene Record

TUBB 203068 Druggable Genome

Alternate Names:

203068
TUBULIN BETA CLASS I
TUBB
CDCBM6
CSCSC1
M40
OK/SW-cl.56
TUBB1
TUBB5
191130
20778
ENSG00000196230
OTTHUMG00000031059
Tubulin beta-5 chain
Tubulin beta chain
2640
P07437
TBB5_HUMAN
BE0000143
ENSG00000183311
ENSG00000224156
ENSG00000232421
ENSG00000235067
ENSG00000229684
ENSG00000137379
TUBULIN BETA-2 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:P07437]
ENSG00000227739
ENSG00000232575
Tubulin beta
T68536
NM_178014
NP_821133

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Name	Tubulin
Interpro Type	Family
Uniprot Evidence	1: Evidence at protein level
Uniprot Status	Swiss-Prot
Interpro Acc	IPR000217
Interpro Short Name	Tubulin
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Tubulins
GuideToPharmacology Gene Category ID	858

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Jordan et al., 1998, Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle., Med Res Rev
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Correia, 1991, Effects of antimitotic agents on tubulin-nucleotide interactions., Pharmacol. Ther.
Jordan et al., 2007, How do microtubule-targeted drugs work? An overview., Curr Cancer Drug Targets
Islam et al., 2004, Microtubulin binding sites as target for developing anticancer agents., Mini Rev Med Chem
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Gupta et al., 2003, Antimicrotubular drugs binding to vinca domain of tubulin., Mol. Cell. Biochem.
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Sève et al., 2010, [Class III beta tubulin expression in nonsmall cell lung cancer]., Rev Mal Respir
Chang et al., 1995, Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer., Semin. Oncol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Kruczynski et al., 1998, Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid., Biochem. Pharmacol.
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Kurtzberg et al., 2009, Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents., Cancer Chemother. Pharmacol.
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Gan et al., 2010, Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin., Mol. Cancer Ther.
Rai SS et al., 1996, Localization of the vinblastine-binding site on beta-tubulin., J Biol Chem
Gerullis H et al., 2017, Vinflunine in the treatment of advanced urothelial cancer: clinical evidence and experience., Ther Adv Urol
Huzil JT et al., 2007, The roles of beta-tubulin mutations and isotype expression in acquired drug resistance., Cancer Inform
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res
Dalbeth N et al., 2014, Mechanism of action of colchicine in the treatment of gout., Clin Ther
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Yee et al., 2005, Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies., Clin. Cancer Res.
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Wolff et al., 1991, Direct photoaffinity labeling of tubulin with colchicine., Proc. Natl. Acad. Sci. U.S.A.
Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
Ngo QA et al., 2009, Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids., J Med Chem
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
Ravindra KC et al., 2015, Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells., Chem Res Toxicol
Hastie SB et al., 1990, Binding of colchiceine to tubulin. Mechanisms of ligand association with tubulin., Biochem Pharmacol
Smith SD et al., 2004, Using immobilized metal affinity chromatography, two-dimensional electrophoresis and mass spectrometry to identify hepatocellular proteins with copper-binding ability., J Proteome Res
Hari M et al., 2006, Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules., Mol Cancer Ther

PHOMOPSIN A TUBB

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19072542

Sources:
DTC
ZD-6126 TUBB

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
BATABULIN TUBB

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SIMOTAXEL TUBB

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
ROSABULIN TUBB

Interaction Score: 0.96

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
MILATAXEL TUBB

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16505100

Sources:
DrugBank
LISAVANBULIN TUBB

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
COMBRETASTATIN A4 TUBB

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 16913727 22543234 25584687 24669888 17765552 25192811

Sources:
DTC
COLCHICINE TUBB

Interaction Score: 0.35

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
23750455 20814887 25805446 22814904 25151572 24502232 20586571 25061803 25937236 16166440 24773591 19527023 25938266 15720245

Sources:
DTC DrugBank GuideToPharmacology ChemblInteractions
VINFLUNINE TUBB

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
8663038 28042310 19455242

Sources:
DrugBank ChemblInteractions
COLCHICEINE TUBB

Interaction Score: 0.32

Interaction Types & Directionality:

binder

Interaction Info:

PMIDs:
2322310

Sources:
DrugBank
DOLASTATIN-10 TUBB

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VINORELBINE TUBB

Interaction Score: 0.3

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
25768699 20403547 7740336 17139284 17016423 9515574

Sources:
DTC DrugBank
VINBLASTINE TUBB

Interaction Score: 0.28

Interaction Types & Directionality:

adduct

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
9664292 23708010 1818332 18220533 15579115 23916255 14619954

Sources:
DTC DrugBank GuideToPharmacology
PATUPILONE TUBB

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
PODOFILOX TUBB

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17765552 2011590 24953821 21402478

Sources:
DTC DrugBank
EPOTHILONE D TUBB

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17139284 17016423

Sources:
DrugBank
VINDESINE TUBB

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NOCODAZOLE TUBB

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21194809 25815147 25369367 25262051 23313639

Sources:
DTC
MEBENDAZOLE TUBB

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
VINCRISTINE TUBB

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16539377 19277662 17139284 21664138 23916255 17016423 20442307

Sources:
DTC TTD DrugBank GuideToPharmacology
ABT-751 TUBB

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC TTD
PACLITAXEL TUBB

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction Mitotic cell cycle arrest in A431 cells

Endogenous Drug? False

PMIDs:
23631389 25369367 25768699 24457094 22595423 23313639 17887662 23387901 19758808 23725535 24953821

Sources:
DTC TTD GuideToPharmacology ChemblInteractions
VERUBULIN TUBB

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
PLINABULIN TUBB

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
ALBENDAZOLE TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CYCLOSTREPTIN TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
CHEMBL1795737 TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
MAYTANSINOL TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL453818 TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
CHEMBL2036124 TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
ZAMPANOLIDE TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
CHEMBL2036119 TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
MAYTANSINE TUBB

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL1935538 TUBB

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
CABAZITAXEL TUBB

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
ERIBULIN TUBB

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology
IXABEPILONE TUBB

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology ChemblInteractions
SAGOPILONE TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEXIBULIN TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PACLITAXEL POLIGLUMEX TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN TROMETHAMINE TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN DISODIUM TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
LARGAZOLE TUBB

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
ERIBULIN MESYLATE TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB EMTANSINE TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRENTUXIMAB VEDOTIN TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
INDIBULIN TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBB

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBB

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBB

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
CURCUMIN TUBB

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC
ARTENIMOL TUBB

Interaction Score: 0.02

Interaction Types & Directionality:

ligand

Interaction Info:

PMIDs:
26340163

Sources:
DrugBank
COPPER TUBB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15359738

Sources:
DrugBank
DOCETAXEL TUBB

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
GuideToPharmacology

Ensembl: ENSG00000196230
- Version: 101_38
Alternate Names:

TUBB Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P07437
- Version: 11-September-2012
Alternate Names:

TUBULIN BETA CHAIN Uniprot Protein Name

203068 Entrez Gene Id

TUBB Uniprot Gene Name

Gene Info:

Interpro Name Tubulin

Interpro Type Family

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000137379
- Version: 26-July-2011
Alternate Names:

TUBULIN BETA-2 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:P07437] Description

TUBB Display Id

ENSG00000137379 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000196230
- Version: 26-July-2011
Alternate Names:

ENSG00000196230 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 203068
- Version: 29-September-2020
Alternate Names:

20778 HUGO Gene ID

20778 HUGO Gene Symbol

tubulin beta class I HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Tubulins

GuideToPharmacology Gene Category ID 858

Publications:

DrugBank: BE0000143

Version: 5.1.7

Alternate Names:

TUBB DrugBank Gene Name

P07437 UniProt Accession

203068 Entrez Gene Id

Gene Info:

Publications:

Sève et al., 2010, [Class III beta tubulin expression in nonsmall cell lung cancer]., Rev Mal Respir

Chang et al., 1995, Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer., Semin. Oncol.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

TTD: Tubulin beta
- Version: 2020.06.01
Alternate Names:

TUBB TTD Gene Abbreviation

T68536 TTD Target ID

Gene Info:

Publications:

Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res

DTC: TUBB

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem

Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett

O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem

ChemblInteractions: TUBB5
- Version: chembl_23
Alternate Names:

TUBB5 GENE_SYMBOL

TUBB GENE_SYMBOL

Tubulin beta chain UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000196230
- Version: 31-May-2017
Alternate Names:

ENSG00000196230 Gene Symbol

TUBB Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	True

Specific Action of the Ligand	Inhibition
Details of Interaction	Mitotic cell cycle arrest in A431 cells
Endogenous Drug?	False

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

Mechanism of Interaction	Tubulin stabiliser
Direct Interaction	yes

TUBULIN BETA CHAIN	Uniprot Protein Name
203068	Entrez Gene Id
TUBB	Uniprot Gene Name

TUBULIN BETA-2 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:P07437]	Description
TUBB	Display Id
ENSG00000137379	Ensembl Gene Id

20778	HUGO Gene ID
20778	HUGO Gene Symbol
tubulin beta class I	HUGO Gene Name

TUBB	DrugBank Gene Name
P07437	UniProt Accession
203068	Entrez Gene Id

binder
inhibitor (inhibitory)

antagonist (inhibitory)
inhibitor (inhibitory)

adduct
inhibitor (inhibitory)

TUBB Gene Record

TUBB 203068 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19072542

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16505100

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 16913727 22543234 25584687 24669888 17765552 25192811

Sources: DTC

Interaction Types & Directionality: binder inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 23750455 20814887 25805446 22814904 25151572 24502232 20586571 25061803 25937236 16166440 24773591 19527023 25938266 15720245

Sources: DTC DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 8663038 28042310 19455242

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: binder

Interaction Info:

PMIDs: 2322310

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info:

PMIDs: 25768699 20403547 7740336 17139284 17016423 9515574

Sources: DTC DrugBank

Interaction Types & Directionality: adduct inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: 9664292 23708010 1818332 18220533 15579115 23916255 14619954

Sources: DTC DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17765552 2011590 24953821 21402478

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
19072542

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
16505100

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
23631389 16913727 22543234 25584687 24669888 17765552 25192811

Sources:
DTC

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
23750455 20814887 25805446 22814904 25151572 24502232 20586571 25061803 25937236 16166440 24773591 19527023 25938266 15720245

Sources:
DTC DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
8663038 28042310 19455242

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

binder

PMIDs:
2322310

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

PMIDs:
25768699 20403547 7740336 17139284 17016423 9515574

Sources:
DTC DrugBank

Interaction Types & Directionality:

adduct

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
9664292 23708010 1818332 18220533 15579115 23916255 14619954

Sources:
DTC DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17765552 2011590 24953821 21402478

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
21194809 25815147 25369367 25262051 23313639

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
16539377 19277662 17139284 21664138 23916255 17016423 20442307

Sources:
DTC TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
25468039

Sources:
DTC TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Details of Interaction Mitotic cell cycle arrest in A431 cells

Endogenous Drug? False

PMIDs:
23631389 25369367 25768699 24457094 22595423 23313639 17887662 23387901 19758808 23725535 24953821

Sources:
DTC TTD GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes