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TUBB Gene Record

  • Summary
  • Interactions
  • Claims
  • TUBB 203068 Druggable Genome

    Alternate Names:

    203068
    TUBULIN BETA CLASS I
    TUBB
    CDCBM6
    CSCSC1
    M40
    OK/SW-cl.56
    TUBB1
    TUBB5
    191130
    20778
    ENSG00000196230
    OTTHUMG00000031059
    Tubulin beta-5 chain
    Tubulin beta chain
    P07437
    TBB5_HUMAN
    ENSG00000183311
    ENSG00000224156
    ENSG00000232421
    ENSG00000235067
    ENSG00000229684
    ENSG00000137379
    TUBULIN BETA-2 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:P07437]
    ENSG00000227739
    ENSG00000232575
    Tubulin beta
    T68536

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Name Tubulin
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Uniprot Status Swiss-Prot
    Interpro Acc IPR000217
    Interpro Short Name Tubulin
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
    Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
    Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
    O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
    Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
    Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
    Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
    Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
    Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
    Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
    Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
    Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
    Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
    Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
    Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
    Correia, 1991, Effects of antimitotic agents on tubulin-nucleotide interactions., Pharmacol. Ther.
    Gupta et al., 2003, Antimicrotubular drugs binding to vinca domain of tubulin., Mol. Cell. Biochem.
    Islam et al., 2004, Microtubulin binding sites as target for developing anticancer agents., Mini Rev Med Chem
    Jordan et al., 2007, How do microtubule-targeted drugs work? An overview., Curr Cancer Drug Targets
    Jordan et al., 1998, Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle., Med Res Rev
    Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
    Sève et al., 2010, [Class III beta tubulin expression in nonsmall cell lung cancer]., Rev Mal Respir
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chang et al., 1995, Pilot study of vinorelbine (Navelbine) and paclitaxel (Taxol) in patients with refractory breast cancer and lung cancer., Semin. Oncol.
    Kruczynski et al., 1998, Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid., Biochem. Pharmacol.
    Kurtzberg et al., 2009, Bone marrow CFU-GM and human tumor xenograft efficacy of three tubulin binding agents., Cancer Chemother. Pharmacol.
    Gan et al., 2010, Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin., Mol. Cancer Ther.
    Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
    Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
    Rai SS et al., 1996, Localization of the vinblastine-binding site on beta-tubulin., J Biol Chem
    Gerullis H et al., 2017, Vinflunine in the treatment of advanced urothelial cancer: clinical evidence and experience., Ther Adv Urol
    Huzil JT et al., 2007, The roles of beta-tubulin mutations and isotype expression in acquired drug resistance., Cancer Inform
    Acharya et al., 2009, Vitamin K3 disrupts the microtubule networks by binding to tubulin: a novel mechanism of its antiproliferative activity., Biochemistry
    Yee et al., 2005, Phase 1 study of ABT-751, a novel microtubule inhibitor, in patients with refractory hematologic malignancies., Clin. Cancer Res.
    Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
    Cerquaglia et al., 2005, Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues: an update., Curr Drug Targets Inflamm Allergy
    Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
    Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
    Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
    Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
    Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
    Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
    Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
    Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res
    Finkelstein et al., 2010, Colchicine poisoning: the dark side of an ancient drug., Clin Toxicol (Phila)
    Dalbeth N et al., 2014, Mechanism of action of colchicine in the treatment of gout., Clin Ther
    Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
    Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
    Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
    Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
    Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
    Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
    Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
    Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
    Wolff et al., 1991, Direct photoaffinity labeling of tubulin with colchicine., Proc. Natl. Acad. Sci. U.S.A.
    Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
    Ngo QA et al., 2009, Synthesis and biological evaluation of vinca alkaloids and phomopsin hybrids., J Med Chem
    Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
    Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
    Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
    Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
  • PHOMOPSIN A   TUBB

    Interaction Score: 2.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19072542


    Sources:
    DTC

  • ZD-6126   TUBB

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • BATABULIN   TUBB

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • SIMOTAXEL   TUBB

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ROSABULIN   TUBB

    Interaction Score: 1.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • LISAVANBULIN   TUBB

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • COMBRETASTATIN A4   TUBB

    Interaction Score: 0.54

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23631389 25584687 17765552 25192811 24669888 22543234 16913727


    Sources:
    DTC

  • COLCHICINE   TUBB

    Interaction Score: 0.42

    Interaction Types & Directionality:
    binder
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    19527023 16166440 20814887 15720245 23750455 25937236 25061803 25805446 24502232 25938266 24773591 22814904 20586571 25151572


    Sources:
    DTC ChemblInteractions

  • DOLASTATIN-10   TUBB

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • VINFLUNINE   TUBB

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    8663038 28042310 19455242


    Sources:
    ChemblInteractions

  • VINORELBINE   TUBB

    Interaction Score: 0.33

    Interaction Types & Directionality:
    antagonist (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    25768699 20403547 17016423 17139284 7740336 9515574


    Sources:
    DTC

  • VINBLASTINE   TUBB

    Interaction Score: 0.32

    Interaction Types & Directionality:
    adduct
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23708010 23916255 1818332 14619954 15579115 18220533 9664292


    Sources:
    DTC

  • VINDESINE   TUBB

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • NOCODAZOLE   TUBB

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25369367 21194809 25815147 23313639 25262051


    Sources:
    DTC

  • PODOFILOX   TUBB

    Interaction Score: 0.26

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    21402478 17765552 24953821 2011590


    Sources:
    DTC

  • MEBENDAZOLE   TUBB

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ALBENDAZOLE   TUBB

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ABT-751   TUBB

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25468039


    Sources:
    DTC TTD

  • VINCRISTINE   TUBB

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19277662 20442307 17016423 17139284 21664138 23916255 16539377


    Sources:
    DTC TTD

  • PACLITAXEL   TUBB

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901


    Sources:
    DTC ChemblInteractions TTD

  • PLINABULIN   TUBB

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • VERUBULIN   TUBB

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions TTD

  • CYCLOSTREPTIN   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17206139


    Sources:
    DTC

  • CHEMBL1795737   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21664138


    Sources:
    DTC

  • MAYTANSINOL   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL453818   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12141877


    Sources:
    DTC

  • CHEMBL2036124   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • ZAMPANOLIDE   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19877653


    Sources:
    DTC

  • CHEMBL2036119   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22543234


    Sources:
    DTC

  • MAYTANSINE   TUBB

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    563462


    Sources:
    DTC

  • CHEMBL1935538   TUBB

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22435708


    Sources:
    DTC

  • SAGOPILONE   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOCETAXEL   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CROLIBULIN   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAVUNETIDE   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LEXIBULIN   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PACLITAXEL POLIGLUMEX   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin stabiliser
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN TROMETHAMINE   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Tubulin disrupting agent
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FOSBRETABULIN DISODIUM   TUBB

    Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • LARGAZOLE   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • ERIBULIN MESYLATE   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • TRASTUZUMAB EMTANSINE   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • BRENTUXIMAB VEDOTIN   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • INDIBULIN   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Tubulin inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINORELBINE TARTRATE   TUBB

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINCRISTINE SULFATE   TUBB

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CABAZITAXEL   TUBB

    Interaction Score: 0.07

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VINBLASTINE SULFATE   TUBB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • IXABEPILONE   TUBB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tubulin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VORINOSTAT   TUBB

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20491440


    Sources:
    DTC

  • CURCUMIN   TUBB

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23830698


    Sources:
    DTC

  • Ensembl: ENSG00000196230

    • Version: 101_38

    Alternate Names:
    TUBB Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P07437

    • Version: 11-September-2012

    Alternate Names:
    TUBULIN BETA CHAIN Uniprot Protein Name
    203068 Entrez Gene Id
    TUBB Uniprot Gene Name

    Gene Info:
    Interpro Name Tubulin
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000137379

    • Version: 26-July-2011

    Alternate Names:
    TUBULIN BETA-2 CHAIN. [SOURCE:UNIPROT/SWISSPROT;ACC:P07437] Description
    TUBB Display Id
    ENSG00000137379 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000196230

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000196230 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Tubulin beta

    • Version: 2020.06.01

    Alternate Names:
    TUBB TTD Gene Abbreviation
    T68536 TTD Target ID

    Gene Info:

    Publications:
    Lu Y et al., 2012, An overview of tubulin inhibitors that interact with the colchicine binding site., Pharm Res

  • DTC: TUBB

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
    Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
    O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem

  • ChemblInteractions: TUBB5

    • Version: chembl_23

    Alternate Names:
    TUBB5 GENE_SYMBOL
    TUBB GENE_SYMBOL
    Tubulin beta chain UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000196230

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000196230 Gene Symbol
    TUBB Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21