DGIdb - TUBA4A Gene Record

TUBA4A 7277 Druggable Genome

Alternate Names:

7277
TUBULIN ALPHA 4A
TUBA4A
ALS22
H2-ALPHA
TUBA1
191110
12407
ENSG00000127824
OTTHUMG00000133126
Testis-specific alpha-tubulin
Tubulin alpha-1 chain
Tubulin H2-alpha
Alpha-tubulin 1
Tubulin alpha-4A chain
P68366
TBA4A_HUMAN
TUBULIN ALPHA-1 CHAIN (ALPHA-TUBULIN 1) (TESTIS-SPECIFIC ALPHA- TUBULIN) (TUBULIN H2-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P68366]
TBA1_HUMAN

Gene Info:

Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Cytoskeleton
Interpro Short Name	Tubulin
Human Readable Name	DRUGGABLE GENOME
Interpro Type	Family
Interpro Name	Tubulin
Uniprot Evidence	1: Evidence at protein level
Interpro Acc	IPR000217
Uniprot Status	Swiss-Prot
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Clark, 1992, Clinical pharmacology and schedule dependency of the podophyllotoxin derivatives., Semin. Oncol.
Alam et al., Applying linear interaction energy method for binding affinity calculations of podophyllotoxin analogues with tubulin using continuum solvent model and prediction of cytotoxic activity., J. Mol. Graph. Model.
Labruère et al., 2010, Design, synthesis, and biological evaluation of the first podophyllotoxin analogues as potential vascular-disrupting agents., ChemMedChem
Li et al., 2010, Competitive mass spectrometry binding assay for characterization of three binding sites of tubulin., J Mass Spectrom
Screpanti et al., 2010, A screen for kinetochore-microtubule interaction inhibitors identifies novel antitubulin compounds., PLoS ONE
Kim et al., 2010, Structure-based virtual screening of novel tubulin inhibitors and their characterization as anti-mitotic agents., Bioorg. Med. Chem.
Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Gan et al., 2010, Microtubule dynamics, mitotic arrest, and apoptosis: drug-induced differential effects of betaIII-tubulin., Mol. Cancer Ther.
Yasui et al., 2010, Live cell imaging of micronucleus formation and development., Mutat. Res.
Vilpo et al., 2000, Selective toxicity of vincristine against chronic lymphocytic leukemia cells in vitro., Eur. J. Haematol.
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod

COMBRETASTATIN A4 TUBA4A

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC
PODOFILOX TUBA4A

Interaction Score: 0.66

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources:
DTC
NOCODAZOLE TUBA4A

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC
COLCHICINE TUBA4A

Interaction Score: 0.3

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
VINCRISTINE TUBA4A

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vincristine sulfate liposomes injection, Onco TCS,Marqibo

Novel drug target Established target

PMIDs:
20442307 20691709 11168494 21664138 23916255 16539377

Sources:
DTC TdgClinicalTrial
PACLITAXEL TUBA4A

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions
CHEMBL453818 TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
MAYTANSINE TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL2036119 TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
CYCLOSTREPTIN TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
ZAMPANOLIDE TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
CHEMBL2036124 TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
CHEMBL1795737 TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
MAYTANSINOL TUBA4A

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CABAZITAXEL TUBA4A

Interaction Score: 0.18

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name cabazitaxel, XRP6258,Jevtana

Novel drug target Established target

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
CHEMBL1935538 TUBA4A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ABT-751 TUBA4A

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC
VINBLASTINE TUBA4A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23708010 23916255

Sources:
DTC
VINORELBINE TUBA4A

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768699

Sources:
DTC
PACLITAXEL POLIGLUMEX TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
VINFLUNINE TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLINABULIN TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERUBULIN TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN DISODIUM TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN TROMETHAMINE TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEXIBULIN TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
SAGOPILONE TUBA4A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
LARGAZOLE TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
TRASTUZUMAB EMTANSINE TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERIBULIN MESYLATE TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRENTUXIMAB VEDOTIN TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
INDIBULIN TUBA4A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBA4A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBA4A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBA4A

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IXABEPILONE TUBA4A

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBA4A

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
CURCUMIN TUBA4A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC

Ensembl: ENSG00000127824
- Version: 101_38
Alternate Names:

TUBA4A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000127824

Version: 26-July-2011

Alternate Names:

TBA1_HUMAN Display Id

ENSG00000127824 Ensembl Gene Id

TUBULIN ALPHA-1 CHAIN (ALPHA-TUBULIN 1) (TESTIS-SPECIFIC ALPHA- TUBULIN) (TUBULIN H2-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P68366] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

TdgClinicalTrial: P68366
- Version: January-2014
Alternate Names:

TUBA4A Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Cytoskeleton

Publications:
HopkinsGroom: P68366
- Version: 11-September-2012
Alternate Names:

P68366 Uniprot Accession

ENSG00000127824 Ensembl Gene Id

TBA4A_HUMAN Uniprot Id

Gene Info:

Interpro Type Family

Human Readable Name DRUGGABLE GENOME

Interpro Name Tubulin

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: TUBA4A

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem

Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem

Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem

ChemblInteractions: TUBA1
- Version: chembl_23
Alternate Names:

Tubulin alpha-1 chain UNIPROT

TUBA1 GENE_SYMBOL

TUBA4A GENE_SYMBOL

Gene Info:

Publications:
HingoraniCasas: ENSG00000127824
- Version: 31-May-2017
Alternate Names:

ENSG00000127824 Gene Symbol

TUBA4A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes

Trial Name	vincristine sulfate liposomes injection, Onco TCS,Marqibo
Novel drug target	Established target

Trial Name	cabazitaxel, XRP6258,Jevtana
Novel drug target	Established target
Mechanism of Interaction	Tubulin inhibitor

Direct Interaction	yes
Mechanism of Interaction	Tubulin stabiliser

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

TBA1_HUMAN	Display Id
ENSG00000127824	Ensembl Gene Id
TUBULIN ALPHA-1 CHAIN (ALPHA-TUBULIN 1) (TESTIS-SPECIFIC ALPHA- TUBULIN) (TUBULIN H2-ALPHA). [SOURCE:UNIPROT/SWISSPROT;ACC:P68366]	Description

P68366	Uniprot Accession
ENSG00000127824	Ensembl Gene Id
TBA4A_HUMAN	Uniprot Id

Tubulin alpha-1 chain	UNIPROT
TUBA1	GENE_SYMBOL
TUBA4A	GENE_SYMBOL

binder
inhibitor (inhibitory)

TUBA4A Gene Record

TUBA4A 7277 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25369367 21194809 25815147 23313639 25262051

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name vincristine sulfate liposomes injection, Onco TCS,Marqibo Novel drug target Established target

PMIDs: 20442307 20691709 11168494 21664138 23916255 16539377

Sources: DTC TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tubulin inhibitor

PMIDs: 23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12141877

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17206139

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19877653

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21664138

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: binder inhibitor (inhibitory)

Interaction Info: Trial Name cabazitaxel, XRP6258,Jevtana Novel drug target Established target Mechanism of Interaction Tubulin inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22435708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25468039

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23708010 23916255

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
1411635 19286405 20979080 20814887 20657644 20810285 21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name vincristine sulfate liposomes injection, Onco TCS,Marqibo

Novel drug target Established target

PMIDs:
20442307 20691709 11168494 21664138 23916255 16539377

Sources:
DTC TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
12141877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17206139

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19877653

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21664138

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

binder

inhibitor (inhibitory)

Interaction Info:

Trial Name cabazitaxel, XRP6258,Jevtana

Novel drug target Established target

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25468039

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23708010 23916255

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25768699

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found