DGIdb - TUBA1A Gene Record

TUBA1A 7846 Druggable Genome

Alternate Names:

7846
TUBULIN ALPHA 1A
TUBA1A
B-ALPHA-1
LIS3
TUBA3
602529
20766
ENSG00000167552
OTTHUMG00000169511
Q71U36
Tubulin alpha-1A chain
Detyrosinated tubulin alpha-1A chain
Alpha-tubulin 3
Tubulin B-alpha-1
Tubulin alpha-3 chain
TBA1A_HUMAN
TBA3_HUMAN
TUBULIN ALPHA-3 CHAIN (ALPHA-TUBULIN 3) (TUBULIN B-ALPHA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q71U36]

Gene Info:

Target Class	Miscellaneous
Target Subclass	StructuralAndAdhesion
Target Subclass	Cytoskeleton
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
Interpro Name	Tubulin
Interpro Short Name	Tubulin
Interpro Type	Family
Interpro Acc	IPR000217
Uniprot Evidence	1: Evidence at protein level
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Oxberry et al., 2001, Assessment of benzimidazole binding to individual recombinant tubulin isotypes from Haemonchus contortus., Parasitology
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Wampande et al., 2007, Classical ligands interact with native and recombinant tubulin from Onchocerca volvulus with similar rank order of magnitude., Protein Expr. Purif.
Lubega et al., 1993, Expression of cloned beta-tubulin genes of Haemonchus contortus in Escherichia coli: interaction of recombinant beta-tubulin with native tubulin and mebendazole., Mol. Biochem. Parasitol.
Ochola et al., 2002, Classical ligands bind tubulin of trypanosomes and inhibit their growth in vitro., J. Parasitol.
MacDonald et al., 2004, Characterisation of benzimidazole binding with recombinant tubulin from Giardia duodenalis, Encephalitozoon intestinalis, and Cryptosporidium parvum., Mol. Biochem. Parasitol.
Field JJ et al., 2009, Microtubule-stabilizing activity of zampanolide, a potent macrolide isolated from the Tongan marine sponge Cacospongia mycofijiensis., J Med Chem
Caldarelli A et al., 2013, Synthesis and tubulin-binding properties of non-symmetrical click C5-curcuminoids., Bioorg Med Chem
Bio M et al., 2013, Site-specific and far-red-light-activatable prodrug of combretastatin A-4 using photo-unclick chemistry., J Med Chem
Galli U et al., 2015, Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents., J Med Chem
Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers., Bioorg Med Chem
Zheng S et al., 2014, Design, synthesis, and biological evaluation of novel pyridine-bridged analogues of combretastatin-A4 as anticancer agents., J Med Chem
Kamal A et al., 2012, Synthesis of chalcone-amidobenzothiazole conjugates as antimitotic and apoptotic inducing agents., Bioorg Med Chem
Pirali T et al., 2006, Synthesis and cytotoxic evaluation of combretafurans, potential scaffolds for dual-action antitumoral agents., J Med Chem
Parrino B et al., 2015, Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: in vitro antiproliferative activity and molecular mechanism(s) of action., Eur J Med Chem
Souto JA et al., 2010, Synthesis and biological characterization of the histone deacetylase inhibitor largazole and C7- modified analogues., J Med Chem
Yi X et al., 2012, Identification of a class of novel tubulin inhibitors., J Med Chem
Reddy MV et al., 2013, Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents., J Med Chem
Wang F et al., 2015, Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity., Bioorg Med Chem
Zhu C et al., 2014, Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence., J Med Chem
Zhang X et al., 2015, Design, synthesis and biological evaluation of colchicine derivatives as novel tubulin and histone deacetylase dual inhibitors., Eur J Med Chem
Wang XF et al., 2014, Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site., J Med Chem
Minegishi H et al., 2015, Methyl 3-((6-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-3-yl)amino)benzoate (GN39482) as a tubulin polymerization inhibitor identified by MorphoBase and ChemProteoBase profiling methods., J Med Chem
Canela MD et al., 2014, Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach., J Med Chem
Zheng J et al., 2013, Elaboration of thorough simplified vinca alkaloids as antimitotic agents based on pharmacophore similarity., Eur J Med Chem
Cheng YY et al., 2013, Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead., Bioorg Med Chem Lett
Correia, 1991, Effects of antimitotic agents on tubulin-nucleotide interactions., Pharmacol. Ther.
Gupta et al., 2003, Antimicrotubular drugs binding to vinca domain of tubulin., Mol. Cell. Biochem.
Islam et al., 2004, Microtubulin binding sites as target for developing anticancer agents., Mini Rev Med Chem
Jordan et al., 2007, How do microtubule-targeted drugs work? An overview., Curr Cancer Drug Targets
Jordan et al., 1998, Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle., Med Res Rev
Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem
Arslanian RL et al., 2002, A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus., J Nat Prod
O'Boyle NM et al., 2014, β-Lactam estrogen receptor antagonists and a dual-targeting estrogen receptor/tubulin ligand., J Med Chem
Kamal A et al., 2011, Synthesis and biological evaluation of 3,5-diaryl isoxazoline/isoxazole linked 2,3-dihydroquinazolinone hybrids as anticancer agents., Eur J Med Chem
Kuroiwa K et al., 2015, Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents., ACS Med Chem Lett
Kumar AS et al., 2013, Design and synthesis of biaryl aryl stilbenes/ethylenes as antimicrotubule agents., Eur J Med Chem
Guan Q et al., 2014, Synthesis and evaluation of benzimidazole carbamates bearing indole moieties for antiproliferative and antitubulin activities., Eur J Med Chem
Vine KL et al., 2007, An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins., J Med Chem
Asami Y et al., 2012, Protuboxepin A, a marine fungal metabolite, inducing metaphase arrest and chromosomal misalignment in tumor cells., Bioorg Med Chem
Sathish Kumar B et al., 2014, Synthesis of neolignans as microtubule stabilisers., Bioorg Med Chem
Zhao Y et al., 2013, Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation., J Med Chem
Kamal A et al., 2014, Synthesis and biological evaluation of 4-aza-2,3-dihydropyridophenanthrolines as tubulin polymerization inhibitors., Bioorg Med Chem Lett
Tu HY et al., 2009, Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species., Bioorg Med Chem
Kumar M et al., 2013, Tubulin inhibitors from an endophytic fungus isolated from Cedrus deodara., J Nat Prod
Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem
Buey RM et al., 2007, Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites., Nat Chem Biol
Kamal A et al., 2014, Synthesis of 2-anilinopyridine dimers as microtubule targeting and apoptosis inducing agents., Bioorg Med Chem
Gasparotto V et al., 2006, Synthesis and biological activity of 7-phenyl-6,9-dihydro-3H-pyrrolo[3,2-f]quinolin-9-ones: a new class of antimitotic agents devoid of aromatase activity., J Med Chem
Kamal A et al., 2011, Synthesis of a new 4-aza-2,3-didehydropodophyllotoxin analogues as potent cytotoxic and antimitotic agents., Bioorg Med Chem

MEBENDAZOLE TUBA1A

Interaction Score: 2.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Mebendazole

Novel drug target Established target

PMIDs:
11444621 10592235 17662615 8139621 12099434 15500920

Sources:
TdgClinicalTrial
COMBRETASTATIN A4 TUBA1A

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC
VINBLASTINE TUBA1A

Interaction Score: 0.39

Interaction Types & Directionality:

adduct

Interaction Info:

PMIDs:
23708010 23916255 1818332 14619954 15579115 18220533 9664292

Sources:
DTC
NOCODAZOLE TUBA1A

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC
COLCHICINE TUBA1A

Interaction Score: 0.29

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions
PODOFILOX TUBA1A

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21402478 17765552 24953821

Sources:
DTC
PACLITAXEL TUBA1A

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions
CYCLOSTREPTIN TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17206139

Sources:
DTC
CHEMBL1795737 TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138

Sources:
DTC
MAYTANSINE TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL2036124 TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
CHEMBL453818 TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12141877

Sources:
DTC
MAYTANSINOL TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
563462

Sources:
DTC
CHEMBL2036119 TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22543234

Sources:
DTC
ZAMPANOLIDE TUBA1A

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19877653

Sources:
DTC
CHEMBL1935538 TUBA1A

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22435708

Sources:
DTC
ABT-751 TUBA1A

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25468039

Sources:
DTC
VINORELBINE TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25768699

Sources:
DTC
SAGOPILONE TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
CROLIBULIN TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINFLUNINE TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LEXIBULIN TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DAVUNETIDE TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DOCETAXEL TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PLINABULIN TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN DISODIUM TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FOSBRETABULIN TROMETHAMINE TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VERUBULIN TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin disrupting agent

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
PACLITAXEL POLIGLUMEX TUBA1A

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin stabiliser

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21664138 23916255 16539377

Sources:
DTC
LARGAZOLE TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
INDIBULIN TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
BRENTUXIMAB VEDOTIN TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ERIBULIN MESYLATE TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
TRASTUZUMAB EMTANSINE TUBA1A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
VINORELBINE TARTRATE TUBA1A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINCRISTINE SULFATE TUBA1A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CABAZITAXEL TUBA1A

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VINBLASTINE SULFATE TUBA1A

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
IXABEPILONE TUBA1A

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
VORINOSTAT TUBA1A

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20491440

Sources:
DTC
CURCUMIN TUBA1A

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23830698

Sources:
DTC

Ensembl: ENSG00000167552
- Version: 101_38
Alternate Names:

TUBA1A Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q71U36
- Version: January-2014
Alternate Names:

TUBA1A Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass StructuralAndAdhesion

Target Subclass Cytoskeleton

Publications:
HopkinsGroom: Q71U36
- Version: 11-September-2012
Alternate Names:

TBA1A_HUMAN Uniprot Id

7846 Entrez Gene Id

ENSG00000167552 Ensembl Gene Id

Gene Info:

Uniprot Status Swiss-Prot

Interpro Name Tubulin

Interpro Short Name Tubulin

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000167552
- Version: 26-July-2011
Alternate Names:

ENSG00000167552 Ensembl Gene Id

TUBULIN ALPHA-3 CHAIN (ALPHA-TUBULIN 3) (TUBULIN B-ALPHA-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q71U36] Description

TBA3_HUMAN Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

DTC: TUBA1A

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kawaratani Y et al., 2011, New microtubule polymerization inhibitors comprising a nitrooxymethylphenyl group., Bioorg Med Chem

Kupchan SM et al., 1978, Structural requirements for antileukemic activity among the naturally occurring and semisynthetic maytansinoids., J Med Chem

Imperio D et al., 2007, Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry., Bioorg Med Chem

ChemblInteractions: TUBA3
- Version: chembl_23
Alternate Names:

TUBA3 GENE_SYMBOL

TUBA1A GENE_SYMBOL

Tubulin alpha-1A chain UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000167552
- Version: 31-May-2017
Alternate Names:

ENSG00000167552 Gene Symbol

TUBA1A Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Mechanism of Interaction	Tubulin inhibitor
Direct Interaction	yes

Mechanism of Interaction	Tubulin stabiliser
Direct Interaction	yes

Mechanism of Interaction	Tubulin disrupting agent
Direct Interaction	yes

TBA1A_HUMAN	Uniprot Id
7846	Entrez Gene Id
ENSG00000167552	Ensembl Gene Id

TUBA3	GENE_SYMBOL
TUBA1A	GENE_SYMBOL
Tubulin alpha-1A chain	UNIPROT

Trial Name	Mebendazole
Novel drug target	Established target

TUBA1A Gene Record

TUBA1A 7846 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Mebendazole Novel drug target Established target

PMIDs: 11444621 10592235 17662615 8139621 12099434 15500920

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources: DTC

Interaction Types & Directionality: adduct

Interaction Info:

PMIDs: 23708010 23916255 1818332 14619954 15579115 18220533 9664292

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25369367 21194809 25815147 23313639 25262051

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21402478 17765552 24953821

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Tubulin inhibitor Direct Interaction yes

PMIDs: 23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17206139

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21664138

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12141877

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 563462

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22543234

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19877653

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22435708

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25468039

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25768699

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Tubulin stabiliser Direct Interaction yes

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Mebendazole

Novel drug target Established target

PMIDs:
11444621 10592235 17662615 8139621 12099434 15500920

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
23631389 25584687 17765552 25192811 24669888 22543234 16913727

Sources:
DTC

Interaction Types & Directionality:

adduct

PMIDs:
23708010 23916255 1818332 14619954 15579115 18220533 9664292

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25369367 21194809 25815147 23313639 25262051

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23750455 25937236 25061803 25805446 24502232 25938266 24773591

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
21402478 17765552 24953821

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
23631389 17887662 22595423 25369367 24457094 23725535 24953821 23313639 25768699 19758808 23387901

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
17206139

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21664138

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12141877

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
563462

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22543234

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
19877653

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22435708

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25468039

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
25768699

Sources:
DTC

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tubulin inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Tubulin stabiliser

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Tubulin inhibitor

Direct Interaction yes

PMIDs:
None found