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TSPO Gene Record

  • Summary
  • Interactions
  • Claims
  • TSPO 706 Druggable Genome

    Alternate Names:

    706
    TRANSLOCATOR PROTEIN
    TSPO
    BPBS
    BZRP
    DBI
    IBP
    MBR
    PBR
    PBS
    PKBS
    PTBR
    mDRC
    pk18
    109610
    1158
    ENSG00000100300
    OTTHUMG00000150573
    P30536
    PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR (PBR) (PKBS) (MITOCHONDRIAL BENZODIAZEPINE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P30536]
    TSPOA_HUMAN
    T75440

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Transmembrane Helix Count 5
    Target Subclass Other
    Target Main Class Transporters
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name TspO_MBR
    Interpro Name TspO/MBR-related protein
    Interpro Type Family
    Interpro Acc IPR004307
    Target Class Transporters
    Target Subclass Miscellaneous
    Target Subclass benzodiazepine translocator protein,
    Gene Biotype PROTEIN_CODING
    (4 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Rupprecht R et al., 2010, Translocator protein (18 kDa) (TSPO) as a therapeutic target for neurological and psychiatric disorders., Nat Rev Drug Discov
    Falchi et al., 2007, Intracellular cholesterol changes induced by translocator protein (18 kDa) TSPO/PBR ligands., Neuropharmacology
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Miller et al., 2006, Detection of benzodiazepines in hair using ELISA and LC-ESI-MS-MS., J Anal Toxicol
    Dobbin et al., 2003, Association of benzodiazepine injection with the prescription of temazepam capsules., Drug Alcohol Rev
    Mant et al., 1993, Benzodiazepine utilisation in Australia: report from a new pharmacoepidemiological database., Aust J Public Health
    Becker et al., 2009, Treatment of sleep dysfunction and psychiatric disorders., Curr Treat Options Neurol
    Jufe, [New hypnotics: perspectives from sleep physiology]., Vertex
    Park et al., 1996, Characterization of peripheral benzodiazepine type sites in a cultured murine BV-2 microglial cell line., Glia
    Katz et al., 1992, Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor., J. Pharmacol. Exp. Ther.
    Venneti et al., 2006, The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging., Prog. Neurobiol.
    Uusi-Oukari et al., 1991, Specific alterations in the cerebellar GABA(A) receptors of an alcohol-sensitive ANT rat line., Alcohol. Clin. Exp. Res.
    Poisnel et al., 2009, Comparison of five benzodiazepine-receptor agonists on buprenorphine-induced mu-opioid receptor regulation., J. Pharmacol. Sci.
    Papadopoulos et al., 1991, Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors., Endocrinology
    Awad et al., 1989, Solubilization of peripheral-type benzodiazepine binding sites from cat cerebral cortex., J. Neurochem.
    Gandolfo et al., 1997, The stimulatory effect of the octadecaneuropeptide (ODN) on cytosolic Ca2+ in rat astrocytes is not mediated through classical benzodiazepine receptors., Eur. J. Pharmacol.
    Papadopoulos et al., 1991, Hormone-stimulated steroidogenesis is coupled to mitochondrial benzodiazepine receptors. Tropic hormone action on steroid biosynthesis is inhibited by flunitrazepam., J. Biol. Chem.
    Carmel et al., 1999, Peripheral-type benzodiazepine receptors in the regulation of proliferation of MCF-7 human breast carcinoma cell line., Biochem. Pharmacol.
    Bono et al., 1999, Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities., Biochem. Biophys. Res. Commun.
    Marano et al., 1990, Enhancement of pharmacologically induced bronchoconstriction by Ro 5-4864., Eur. J. Pharmacol.
    Bolger et al., 1990, Interactions between peripheral-type benzodiazepine receptor ligands and an activator of voltage-operated calcium channels., Can. J. Physiol. Pharmacol.
    Campagna et al., 2004, Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives., Farmaco
  • CHLORMEZANONE   TSPO

    Interaction Score: 10.91

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 11752352


    Sources:
    TdgClinicalTrial TEND TTD

  • DIAZEPINOMICIN   TSPO

    Interaction Score: 3.64

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name TLN-4601, ECO-4601
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD

  • FLUNITRAZEPAM   TSPO

    Interaction Score: 2.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    19443999 1320691 1651852 2723642 9098698 1847384


    Sources:
    TdgClinicalTrial TEND TTD

  • ALPIDEM   TSPO

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ONO-2952   TSPO

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DEXTOFISOPAM   TSPO

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ZOPICLONE   TSPO

    Interaction Score: 1.82

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17016423 17139284 21119734


    Sources:
    TdgClinicalTrial TEND

  • ZALEPLON   TSPO

    Interaction Score: 1.82

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name AZ-007, Staccato zaleplon
    Novel drug target Established target
    Trial Name SKP-1041, delayed-release zaleplon

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • PYRAZOLE   TSPO

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15544788


    Sources:
    NCI

  • METRONIDAZOLE   TSPO

    Interaction Score: 0.91

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1320691


    Sources:
    NCI

  • ESZOPICLONE   TSPO

    Interaction Score: 0.61

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name Lunesta

    PMIDs:
    19744401 18265473 17016423 17139284


    Sources:
    TdgClinicalTrial TTD

  • LORAZEPAM   TSPO

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    17156911 1647706 16959136 8787774


    Sources:
    TdgClinicalTrial TEND TTD

  • CLONAZEPAM   TSPO

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10423168 10558889 2364987 2723642 1691678 11752352


    Sources:
    TEND

  • TEMAZEPAM   TSPO

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    16959136 12850901 7911332


    Sources:
    TdgClinicalTrial TEND TTD

  • OLESOXIME   TSPO

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name olesoxime, TRO19622
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CLORAZEPIC ACID   TSPO

    Interaction Score: 0.36

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    8787774


    Sources:
    TdgClinicalTrial TEND TTD

  • DIAZEPAM   TSPO

    Interaction Score: 0.24

    Interaction Types & Directionality:
    potentiator

    Interaction Info:

    PMIDs:
    17631921 11752352


    Sources:
    TEND TTD

  • ZOLPIDEM   TSPO

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND

  • TRIAZOLAM   TSPO

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8787774


    Sources:
    TEND TTD

  • ALPRAZOLAM   TSPO

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TEND TTD

  • FLUDIAZEPAM   TSPO

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CINOLAZEPAM   TSPO

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ADINAZOLAM   TSPO

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CLOTIAZEPAM   TSPO

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FLUMAZENIL   TSPO

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DISULFIRAM   TSPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1320691


    Sources:
    NCI

  • HALAZEPAM   TSPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • QUAZEPAM   TSPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CHLORDIAZEPOXIDE   TSPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FLURAZEPAM   TSPO

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PRAZEPAM   TSPO

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • ESTAZOLAM   TSPO

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OXAZEPAM   TSPO

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MIDAZOLAM   TSPO

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • Ensembl: ENSG00000100300

    • Version: 101_38

    Alternate Names:
    TSPO Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P30536

    • Version: 01-August-2011

    Alternate Names:
    TSPOA_HUMAN Uniprot Id
    706 Entrez Gene Id
    BZRP Gene Symbol

    Gene Info:
    Transmembrane Helix Count 5
    Target Subclass Other
    Target Main Class Transporters

    Publications:

  • TdgClinicalTrial: P30536

    • Version: January-2014

    Alternate Names:
    TSPO Gene Symbol
    BZRP Gene Symbol

    Gene Info:
    Target Class Transporters
    Target Subclass Miscellaneous
    Target Subclass benzodiazepine translocator protein,

    Publications:

  • RussLampel: ENSG00000100300

    • Version: 26-July-2011

    Alternate Names:
    PERIPHERAL-TYPE BENZODIAZEPINE RECEPTOR (PBR) (PKBS) (MITOCHONDRIAL BENZODIAZEPINE RECEPTOR). [SOURCE:UNIPROT/SWISSPROT;ACC:P30536] Description
    BZRP Display Id
    ENSG00000100300 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P30536

    • Version: 11-September-2012

    Alternate Names:
    TRANSLOCATOR PROTEIN Uniprot Protein Name
    706 Entrez Gene Id
    TSPO Uniprot Gene Name

    Gene Info:
    Uniprot Status Swiss-Prot
    Uniprot Evidence 1: Evidence at protein level
    Interpro Short Name TspO_MBR

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: TSPO

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Katz et al., 1992, Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor., J. Pharmacol. Exp. Ther.
    Campagna et al., 2004, Synthesis, central and peripheral benzodiazepine receptor affinity of pyrazole and pyrazole-containing polycyclic derivatives., Farmaco

  • HingoraniCasas: ENSG00000100300

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000100300 Gene Symbol
    TSPO Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TTD: Translocator protein

    • Version: 2020.06.01

    Alternate Names:
    TSPO TTD Gene Abbreviation
    T75440 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21