-
TRPM8 79054 Druggable Genome
Alternate Names:
79054 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 TRPM8 LTRPC6 LTrpC-6 TRPP8 trp-p8 606678 17961 ENSG00000144481 OTTHUMG00000059129 Long transient receptor potential channel 6 Transient receptor potential p8 Q7Z2W7 TRPM8_HUMAN BE0001186 500 TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 (TRANSIENT RECEPTOR POTENTIAL-P8) (TRP-P8) (LONG TRANSIENT RECEPTOR POTENTIAL CHANNEL 6) (LTRPC6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q7Z2W7] NP_076985 NM_024080 Long transient receptor potential channel 8 T41955 Gene Info:
Interpro Type Domain Interpro Acc IPR005821 Human Readable Name ION CHANNEL Uniprot Status Swiss-Prot Human Readable Name DRUGGABLE GENOME Uniprot Evidence 2: Evidence at transcript level Interpro Short Name Ion_trans_dom Interpro Name Ion transport domain Target Main Class Transporters Transmembrane Helix Count 8 Target Subclass TRP_channels Target Subclass Channels Target Subclass Voltage_gated_ion_channels Initial Gene Query TRPM8 Counted Citations from 1950-2000 331 Target Class Transporters Target Subclass TC:1.A.4.5.7 GuideToPharmacology Gene Category Name Transient Receptor Potential channels GuideToPharmacology Gene Category ID 78 Gene Biotype PROTEIN_CODING Gene Categories: Category Details
ION CHANNEL EXTERNAL SIDE OF PLASMA MEMBRANE DRUGGABLE GENOME Publications:
-
Interaction Types & Directionality:
inducer (activating) Interaction Info:
Trial Name - Novel drug target Established target Mechanism of Interaction Transient receptor potential cation channel subfamily M member 8 opener -
Interaction Types & Directionality:
agonist (activating) Interaction Info:
Mechanism of Interaction Transient receptor potential cation channel subfamily M member 8 agonist Direct Interaction yes -
Interaction Score: 8.74
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand Antagonist Endogenous Drug? False Direct Interaction? False -
Interaction Score: 6.99
-
Interaction Score: 4.37
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False -
Interaction Score: 4.37
Interaction Types & Directionality:
antagonist (inhibitory) Interaction Info:
Details of the Assay for Interaction Inhibition of menthol-induced intracellular calcium mobilisation using HEK293 cells stably expressing hTRPM8. Specific Action of the Ligand Antagonist Endogenous Drug? False -
Interaction Score: 1.75
-
Interaction Score: 1.25
-
Interaction Score: 0.3
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand None -
Interaction Score: 0.27
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False -
Interaction Score: 0.2
-
Interaction Score: 0.12
Interaction Types & Directionality:
blocker (inhibitory) Interaction Info:
Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False
-
- Version: 101_38
Alternate Names:
TRPM8 Ensembl Gene Name Gene Info:
Gene Biotype PROTEIN_CODING Publications:
-
Alternate Names:
Q7Z2W7 Uniprot Accession TRPM8_HUMAN Uniprot Id TRPM8 Gene Symbol Gene Info:
Target Main Class Transporters Transmembrane Helix Count 8 Target Subclass TRP_channels Publications:
-
- Version: 26-July-2011
Alternate Names:
TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 (TRANSIENT RECEPTOR POTENTIAL-P8) (TRP-P8) (LONG TRANSIENT RECEPTOR POTENTIAL CHANNEL 6) (LTRPC6). [SOURCE:UNIPROT/SWISSPROT;ACC:Q7Z2W7] Description ENSG00000144481 Ensembl Gene Id TRPM8 Display Id Gene Info:
Human Readable Name DRUGGABLE GENOME Gene Categories:
DRUGGABLE GENOME Publications:
-
- Version: February-2014
Alternate Names:
79054 Entrez Gene ID Gene Info:
Initial Gene Query TRPM8 Counted Citations from 1950-2000 331 Gene Categories:
ION CHANNEL Publications:
-
- Version: 11-September-2012
Alternate Names:
TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 8 Uniprot Protein Name TRPM8_HUMAN Uniprot Id ENSG00000144481 Ensembl Gene Id Gene Info:
Interpro Type Domain Interpro Acc IPR005821 Human Readable Name ION CHANNEL Gene Categories:
ION CHANNEL, DRUGGABLE GENOME Publications:
-
- Version: January-2014
Alternate Names:
TRPM8 Gene Symbol Gene Info:
Target Class Transporters Target Subclass TC:1.A.4.5.7 Publications:
-
- Version: 29-September-2020
Alternate Names:
17961 HUGO Gene ID 17961 HUGO Gene Symbol transient receptor potential cation channel subfamily M member 8 HUGO Gene Name Gene Info:
GuideToPharmacology Gene Category Name Transient Receptor Potential channels GuideToPharmacology Gene Category ID 78 Gene Categories:
ION CHANNEL Publications:
-
Alternate Names:
TRPM8 DrugBank Gene Name Q7Z2W7 UniProt Accession 79054 Entrez Gene Id Gene Info:
Publications:
-
- Version: 2020.06.01
Alternate Names:
TRPM8 TTD Gene Abbreviation T41955 TTD Target ID Gene Info:
-
- Version: 31-May-2017
Alternate Names:
ENSG00000144481 Gene Symbol TRPM8 Ensembl Id Gene Info:
Gene Categories:
DRUGGABLE GENOME Publications:
-
- Version: chembl_23
Alternate Names:
TRPP8 GENE_SYMBOL TRPM8 GENE_SYMBOL Transient receptor potential cation channel subfamily M member 8 UNIPROT Gene Info:
Publications:
-
Alternate Names:
Transient receptor potential cation channel subfamily M member 8 Gene Name Q7Z2W7 UniProt ID Gene Info:
Gene Categories:
ION CHANNEL Publications:
-
Alternate Names:
LTRPC6 GO Gene Synonym TRPP8 GO Gene Synonym Gene Info:
Gene Categories:
EXTERNAL SIDE OF PLASMA MEMBRANE Publications: