DGIdb - TPMT Gene Record

TPMT 7172 Druggable Genome

Alternate Names:

7172
THIOPURINE S-METHYLTRANSFERASE
TPMT
TPMTD
187680
12014
ENSG00000137364
OTTHUMG00000014317
PA356
P51580

Gene Info:

Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit
Cabaleiro T et al., 2013, Polymorphisms influencing olanzapine metabolism and adverse effects in healthy subjects., Hum Psychopharmacol
Khrunin AV et al., 2014, Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer., Pharmacogenomics
Karas-Kuželički N et al., 2014, From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity., Pharmacogenomics
Formea CM et al., 2004, Thiopurine S-methyltransferase genotype predicts azathioprine-induced myelotoxicity in kidney transplant recipients., Am J Transplant

ADEMETIONINE TPMT

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25303295

Sources:
PharmGKB
PREDNISONE TPMT

Interaction Score: 0.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16044099

Sources:
PharmGKB
CYCLOSPORINE TPMT

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16044099 15476481

Sources:
PharmGKB
AZATHIOPRINE TPMT

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
THIOGUANINE TPMT

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
OLANZAPINE TPMT

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23559402

Sources:
PharmGKB
MERCAPTOPURINE TPMT

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA
CYCLOPHOSPHAMIDE TPMT

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24533712

Sources:
PharmGKB
CISPLATIN TPMT

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

Ensembl: ENSG00000137364
- Version: 101_38
Alternate Names:

TPMT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: TPMT

Version: 18-August-2020

Alternate Names:

PA356 PharmGKB ID

Gene Info:

Publications:

Kurzawski M et al., 2005, The impact of thiopurine s-methyltransferase polymorphism on azathioprine-induced myelotoxicity in renal transplant recipients., Ther Drug Monit

Karas-Kuželički N et al., 2014, From pharmacogenetics to pharmacometabolomics: SAM modulates TPMT activity., Pharmacogenomics

Lee MN et al., 2015, Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine., Inflamm Bowel Dis

HingoraniCasas: ENSG00000137364
- Version: 31-May-2017
Alternate Names:

ENSG00000137364 Gene Symbol

TPMT Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Tempus: TPMT
- Version: 11-November-2018
Alternate Names:

TPMT Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: TPMT
- Version: 01-February-2022
Alternate Names:

Thiopurine S-methyltransferase Gene Name

P51580 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
FDA: TPMT
- Version: 04-September-2020
Alternate Names:

Gene Info:

Publications:

TPMT Gene Record

TPMT 7172 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25303295

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16044099

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16044099 15476481

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23559402

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24533712

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

Ensembl: ENSG00000137364

Alternate Names: TPMT Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: TPMT

Alternate Names: PA356 PharmGKB ID

Gene Info:

HingoraniCasas: ENSG00000137364

Alternate Names: ENSG00000137364 Gene Symbol TPMT Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Tempus: TPMT

Alternate Names: TPMT Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: TPMT

Alternate Names: Thiopurine S-methyltransferase Gene Name P51580 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

FDA: TPMT

Alternate Names:

Gene Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25303295

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16044099

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16044099 15476481

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
23559402

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Interaction Types & Directionality:

n/a

PMIDs:
24533712

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

TPMT Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA356 PharmGKB ID

Alternate Names:

ENSG00000137364 Gene Symbol

TPMT Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TPMT Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Thiopurine S-methyltransferase Gene Name

P51580 UniProt ID

Gene Categories:

ENZYME