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TPM3 Gene Record

  • Summary
  • Interactions
  • Claims
  • TPM3 7170 Clinically Actionable

    Alternate Names:

    7170
    TROPOMYOSIN 3
    TPM3
    CAPM1
    CFTD
    HEL-189
    HEL-S-82p
    NEM1
    OK/SW-cl.5
    TM-5
    TM3
    TM30
    TM30nm
    TM5
    TPMsk3
    TRK
    hscp30
    191030
    12012
    ENSG00000143549
    OTTHUMG00000035853
    TPM3nu
    P06753
    Tropomyosin alpha-3 chain

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Peters et al., 1993, Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism., Int. J. Cancer
    Patil et al., 2008, Analysis of efficacy of chiral adrenergic agonists., Chirality
    Chen et al., 2007, Molecular identification of the human melanocortin-2 receptor responsible for ligand binding and signaling., Biochemistry
    Kaur et al., 2007, Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants., J. Neurosci. Res.
    Lu et al., 2006, General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain., Apoptosis
    Kumano et al., 2000, HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells., Brain Res.
    Volonté et al., 1993, A purine analog-sensitive protein kinase activity associates with Trk nerve growth factor receptors., J. Neurochem.
  • APAZIQUONE   TPM3

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8509220


    Sources:
    NCI

  • CORTICOTROPIN   TPM3

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17877367


    Sources:
    NCI

  • THIOGUANINE   TPM3

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7687657


    Sources:
    NCI

  • EPINEPHRINE   TPM3

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18172836


    Sources:
    NCI

  • MIDAZOLAM   TPM3

    Interaction Score: 0.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16738805


    Sources:
    NCI

  • SIMVASTATIN   TPM3

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10720627


    Sources:
    NCI

  • PROGESTERONE   TPM3

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17549730


    Sources:
    NCI

  • METHOTREXATE   TPM3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8509220


    Sources:
    NCI

  • Ensembl: ENSG00000143549

    • Version: 101_38

    Alternate Names:
    TPM3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: TPM3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Vogt et al., 1997, RNA fingerprinting displays UVB-specific disruption of transcriptional control in human melanocytes., Cancer Res.
    Mulet et al., 2004, The trehalose pathway and intracellular glucose phosphates as modulators of potassium transport and general cation homeostasis in yeast., Yeast
    Peters et al., 1993, Transformation of mouse fibroblasts with the oncogenes H-ras OR trk is associated with pronounced changes in drug sensitivity and metabolism., Int. J. Cancer

  • Pharos: TPM3

    • Version: 01-February-2022

    Alternate Names:
    Tropomyosin alpha-3 chain Gene Name
    P06753 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • FoundationOneGenes: TPM3

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: TPM3

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21