DGIdb - TPH2 Gene Record

TPH2 121278 Druggable Genome

Alternate Names:

121278
TRYPTOPHAN HYDROXYLASE 2
TPH2
ADHD7
NTPH
607478
20692
ENSG00000139287
OTTHUMG00000169677
TRYPTOPHAN 5-HYDROXYLASE 2 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 2) (NEURONAL TRYPTOPHAN HYDROXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8IWU9]
Q8IWU9
Tryptophan 5-monooxygenase 2
Tryptophan 5-hydroxylase 2
Neuronal tryptophan hydroxylase
PA128747823
TPH2_HUMAN
L-Tryptophan hydroxylase 2
1242

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Short Name	ArAA_hydroxylase
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Aromatic amino acid hydroxylase
Uniprot Status	Swiss-Prot
Interpro Type	Family
Interpro Acc	IPR001273
Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Amino acid hydroxylases
GuideToPharmacology Gene Category ID	249

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics
Rotberg B et al., 2013, Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders., J Child Adolesc Psychopharmacol

RODATRISTAT TPH2

Interaction Score: 3.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
FENFLURAMINE TPH2

Interaction Score: 3.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
TELOTRISTAT ETHYL TPH2

Interaction Score: 3.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
TELOTRISTAT TPH2

Interaction Score: 3.99

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
FENCLONINE TPH2

Interaction Score: 1.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
VENLAFAXINE TPH2

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18496129

Sources:
PharmGKB
MIRTAZAPINE TPH2

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18496129

Sources:
PharmGKB
CITALOPRAM TPH2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23510446

Sources:
PharmGKB

Ensembl: ENSG00000139287
- Version: 101_38
Alternate Names:

TPH2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139287

Version: 26-July-2011

Alternate Names:

ENSG00000139287 Ensembl Gene Id

TRYPTOPHAN 5-HYDROXYLASE 2 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 2) (NEURONAL TRYPTOPHAN HYDROXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8IWU9] Description

TPH2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q8IWU9
- Version: 11-September-2012
Alternate Names:

TRYPTOPHAN 5-HYDROXYLASE 2 Uniprot Protein Name

Q8IWU9 Uniprot Accession

TPH2 Uniprot Gene Name

Gene Info:

Interpro Short Name ArAA_hydroxylase

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 121278
- Version: 29-September-2020
Alternate Names:

20692 HUGO Gene ID

20692 HUGO Gene Symbol

tryptophan hydroxylase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Amino acid hydroxylases

GuideToPharmacology Gene Category ID 249

Gene Categories:

ENZYME

Publications:

PharmGKB: TPH2

Version: 18-August-2020

Alternate Names:

PA128747823 PharmGKB ID

Gene Info:

Publications:

Rotberg B et al., 2013, Additive effects of 5-HTTLPR (serotonin transporter) and tryptophan hydroxylase 2 G-703T gene polymorphisms on the clinical response to citalopram among children and adolescents with depression and anxiety disorders., J Child Adolesc Psychopharmacol

Fabbri C et al., 2014, Understanding the pharmacogenetics of selective serotonin reuptake inhibitors., Expert Opin Drug Metab Toxicol

Tzvetkov MV et al., 2008, Common genetic variations in human brain-specific tryptophan hydroxylase-2 and response to antidepressant treatment., Pharmacogenet Genomics

ChemblInteractions: NTPH
- Version: chembl_23
Alternate Names:

NTPH GENE_SYMBOL

TPH2 GENE_SYMBOL

Tryptophan 5-hydroxylase 2 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000139287
- Version: 31-May-2017
Alternate Names:

ENSG00000139287 Gene Symbol

TPH2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

Direct Interaction	yes
Mechanism of Interaction	Tryptophan 5-hydroxylase inhibitor

ENSG00000139287	Ensembl Gene Id
TRYPTOPHAN 5-HYDROXYLASE 2 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 2) (NEURONAL TRYPTOPHAN HYDROXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8IWU9]	Description
TPH2	Display Id

TRYPTOPHAN 5-HYDROXYLASE 2	Uniprot Protein Name
Q8IWU9	Uniprot Accession
TPH2	Uniprot Gene Name

20692	HUGO Gene ID
20692	HUGO Gene Symbol
tryptophan hydroxylase 2	HUGO Gene Name

NTPH	GENE_SYMBOL
TPH2	GENE_SYMBOL
Tryptophan 5-hydroxylase 2	UNIPROT

antagonist (inhibitory)
inhibitor (inhibitory)

TPH2 Gene Record

TPH2 121278 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18496129

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18496129

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23510446

Sources: PharmGKB

Ensembl: ENSG00000139287

Alternate Names: TPH2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000139287

Alternate Names: ENSG00000139287 Ensembl Gene Id TRYPTOPHAN 5-HYDROXYLASE 2 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 2) (NEURONAL TRYPTOPHAN HYDROXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8IWU9] Description TPH2 Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

HopkinsGroom: Q8IWU9

Alternate Names: TRYPTOPHAN 5-HYDROXYLASE 2 Uniprot Protein Name Q8IWU9 Uniprot Accession TPH2 Uniprot Gene Name

Gene Info: Interpro Short Name ArAA_hydroxylase Human Readable Name DRUGGABLE GENOME Uniprot Evidence 1: Evidence at protein level

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 121278

Alternate Names: 20692 HUGO Gene ID 20692 HUGO Gene Symbol tryptophan hydroxylase 2 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Amino acid hydroxylases GuideToPharmacology Gene Category ID 249

Gene Categories: ENZYME

Publications:

PharmGKB: TPH2

Alternate Names: PA128747823 PharmGKB ID

Gene Info:

ChemblInteractions: NTPH

Alternate Names: NTPH GENE_SYMBOL TPH2 GENE_SYMBOL Tryptophan 5-hydroxylase 2 UNIPROT

Gene Info:

Publications:

HingoraniCasas: ENSG00000139287

Alternate Names: ENSG00000139287 Gene Symbol TPH2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Tryptophan 5-hydroxylase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18496129

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18496129

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23510446

Sources:
PharmGKB

Alternate Names:

TPH2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000139287 Ensembl Gene Id

TRYPTOPHAN 5-HYDROXYLASE 2 (EC 1.14.16.4) (TRYPTOPHAN 5-MONOOXYGENASE 2) (NEURONAL TRYPTOPHAN HYDROXYLASE). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8IWU9] Description

TPH2 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TRYPTOPHAN 5-HYDROXYLASE 2 Uniprot Protein Name

Q8IWU9 Uniprot Accession

TPH2 Uniprot Gene Name

Gene Info:

Interpro Short Name ArAA_hydroxylase

Human Readable Name DRUGGABLE GENOME

Uniprot Evidence 1: Evidence at protein level

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

20692 HUGO Gene ID

20692 HUGO Gene Symbol

tryptophan hydroxylase 2 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Amino acid hydroxylases

GuideToPharmacology Gene Category ID 249

Gene Categories:

ENZYME

Alternate Names:

PA128747823 PharmGKB ID

Alternate Names:

NTPH GENE_SYMBOL

TPH2 GENE_SYMBOL

Tryptophan 5-hydroxylase 2 UNIPROT

Alternate Names:

ENSG00000139287 Gene Symbol

TPH2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME