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TP73 Gene Record

  • Summary
  • Interactions
  • Claims
  • TP73 7161 Druggable Genome

    Alternate Names:

    7161
    TUMOR PROTEIN P73
    TP73
    P73
    601990
    12003
    ENSG00000078900
    OTTHUMG00000000610
    O15350
    P73_HUMAN
    TUMOR PROTEIN P73 (P53-LIKE TRANSCRIPTION FACTOR) (P53-RELATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O15350]
    CILD47

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name p53_tumour_suppressor
    Interpro Type Family
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR002117
    Uniprot Status Swiss-Prot
    Interpro Name p53 tumour suppressor family
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TUMOR SUPPRESSOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Kikuchi et al., 2004, Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes., Int. Immunol.
    Papoutsaki et al., 2004, The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene., J. Invest. Dermatol.
    Koivusalo et al., 2002, Chemoradiation of cervical cancer cells: targeting human papillomavirus E6 and p53 leads to either augmented or attenuated apoptosis depending on the platinum carrier ligand., Cancer Res.
    Amin et al., 2007, SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG., Proc. Natl. Acad. Sci. U.S.A.
    Ono et al., 2001, Loss of p73 induction in a cisplatin-resistant bladder cancer cell line., Mol Urol
  • TAZAROTENE   TP73

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15610529


    Sources:
    NCI

  • REGRAMOSTIM   TP73

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15126418


    Sources:
    NCI

  • EPIGALOCATECHIN GALLATE   TP73

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17369354


    Sources:
    NCI

  • CARBOPLATIN   TP73

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12499281


    Sources:
    NCI

  • CISPLATIN   TP73

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11689148


    Sources:
    NCI

  • Ensembl: ENSG00000078900

    • Version: 101_38

    Alternate Names:
    TP73 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000078900

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000078900 Ensembl Gene Id
    TP73 Display Id
    TUMOR PROTEIN P73 (P53-LIKE TRANSCRIPTION FACTOR) (P53-RELATED PROTEIN). [SOURCE:UNIPROT/SWISSPROT;ACC:O15350] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: O15350

    • Version: 11-September-2012

    Alternate Names:
    O15350 Uniprot Accession
    ENSG00000078900 Ensembl Gene Id
    7161 Entrez Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME
    Interpro Short Name p53_tumour_suppressor
    Interpro Type Family

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: TP73

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Amin et al., 2007, SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG., Proc. Natl. Acad. Sci. U.S.A.
    Catani et al., 2002, Ascorbate up-regulates MLH1 (Mut L homologue-1) and p73: implications for the cellular response to DNA damage., Biochem. J.
    Pozniak et al., 2000, An anti-apoptotic role for the p53 family member, p73, during developmental neuron death., Science

  • GO: TP73

    • Version: 01-February-2022

    Alternate Names:
    P73 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TUMOR SUPPRESSOR

    Publications:

  • Pharos: TP73

    • Version: 01-February-2022

    Alternate Names:
    Tumor protein p73 Gene Name
    O15350 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21