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TOP2A Gene Record

  • Summary
  • Interactions
  • Claims
  • TOP2A 7153 Druggable GenomeClinically Actionable

    Alternate Names:

    7153
    DNA TOPOISOMERASE II ALPHA
    TOP2A
    TOP2
    TP2A
    126430
    11989
    ENSG00000131747
    OTTHUMG00000155008
    DNA topoisomerase II, alpha isozyme
    DNA topoisomerase 2-alpha
    TOPOISOMERASE II ALPHA (FRAGMENT). [SOURCE:UNIPROT/SPTREMBL;ACC:Q71UQ5]
    Q71UN1_HUMAN
    PA354
    P11388
    TOP2A_HUMAN
    T17048
    TOP2alpha
    TOPIIA

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:5.99.1.3
    Interpro Name DNA topoisomerase, type IIA
    Interpro Type Domain
    Interpro Short Name Topo_IIA
    Interpro Short Name Topo_IIA_A/C
    Interpro Type Family
    Interpro Acc IPR003594
    Interpro Name ATPase-like, ATP-binding domain
    Interpro Name DNA topoisomerase, type IIA, subunit A/C-terminal
    Uniprot Evidence 1: Evidence at protein level
    Interpro Acc IPR001241
    Interpro Short Name ATPase-like_ATP-bd
    Uniprot Status Swiss-Prot
    Interpro Acc IPR002205
    Target Subclass 5.99.1.3
    Target Main Class Enzymes
    Gene Biotype PROTEIN_CODING
    (12 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    CLINICALLY ACTIONABLE
    ENZYME

    Publications:

    Kurata et al., 2007, Amrubicin for non-small-cell lung cancer and small-cell lung cancer., Invest New Drugs
    Petit et al., 2004, Comparative value of tumour grade, hormonal receptors, Ki-67, HER-2 and topoisomerase II alpha status as predictive markers in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy., Eur. J. Cancer
    Liang et al., 2007, Solamargine upregulation of Fas, downregulation of HER2, and enhancement of cytotoxicity using epirubicin in NSCLC cells., Mol Nutr Food Res
    Knoop et al., 2005, retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group., J. Clin. Oncol.
    Kamal A et al., 2011, Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents., Bioorg Med Chem
    Evdokimov NM et al., 2011, Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents., J Med Chem
    Tan S et al., 2015, Antiproliferative and apoptosis-inducing activities of novel naphthalimide-cyclam conjugates through dual topoisomerase (topo) I/II inhibition., Bioorg Med Chem
    Chhikara BS et al., 2012, Synthesis, anticancer activities, and cellular uptake studies of lipophilic derivatives of doxorubicin succinate., J Med Chem
    Chen Z et al., 2010, A new class of naphthalimide-based antitumor agents that inhibit topoisomerase II and induce lysosomal membrane permeabilization and apoptosis., J Med Chem
    Hayashi et al., 2006, Enhancement of radiosensitivity by topoisomerase II inhibitor, amrubicin and amrubicinol, in human lung adenocarcinoma A549 cells and kinetics of apoptosis and necrosis induction., Int. J. Mol. Med.
    Koehn et al., 2007, Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin., Anticancer Drugs
    Rody et al., 2007, Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor response., Breast
    Azarova et al., 2007, Roles of DNA topoisomerase II isozymes in chemotherapy and secondary malignancies., Proc. Natl. Acad. Sci. U.S.A.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Menendez et al., 2006, DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes., Int. J. Mol. Med.
    Jiménez-Alonso S et al., 2008, Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors., J Med Chem
    Sperry J et al., 2009, Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum., Bioorg Med Chem
    Brown et al., 1998, Immunohistochemical staining for DNA topoisomerase IIa in Hodgkin's disease., Am. J. Clin. Pathol.
    Faure et al., 1996, [Topoisomerases: therapeutic value]., Ann Pharm Fr
    Umanskaya et al., Inhibition of DNA topoisomerase II in living cells stimulates illegitimate recombination., Dokl. Biochem. Biophys.
    de Lucio et al., 2005, Characterization of human NSCLC cell line with innate etoposide-resistance mediated by cytoplasmic localization of topoisomerase II alpha., Cancer Sci.
    Winnicka et al., Cardiac glycosides in cancer research and cancer therapy., Acta Pol Pharm
    Uesaka et al., 2007, Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity., J. Neurooncol.
    Schmidt EW et al., 1995, Makaluvamines H-M and damirone C from the pohnpeian sponge Zyzzya fuliginosa., J Nat Prod
    Aubel-Sadron et al., 1984, Daunorubicin and doxorubicin, anthracycline antibiotics, a physicochemical and biological review., Biochimie
    Zunino et al., 1990, DNA topoisomerase II as the primary target of anti-tumor anthracyclines., Anticancer Drug Des.
    McPherson et al., Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha., Anticancer Res.
    Guerrant W et al., 2012, Dual targeting of histone deacetylase and topoisomerase II with novel bifunctional inhibitors., J Med Chem
    Shi DK et al., 2012, Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors., Eur J Med Chem
    Ko et al., 2008, Acute promyelocytic leukemic involvement of the optic nerves following mitoxantrone treatment for multiple sclerosis., J. Neurol. Sci.
    Mao et al., 1999, Mutations of human topoisomerase II alpha affecting multidrug resistance and sensitivity., Biochemistry
    Wang et al., 2001, Atp-bound topoisomerase ii as a target for antitumor drugs., J. Biol. Chem.
    Takeda et al., 1998, A case of therapy-related acute myeloblastic leukemia with t(16;21)(q24;q22) after chemotherapy with DNA-topoisomerase II inhibitors, etoposide and mitoxantrone, and the alkylating agent, cyclophosphamide., Int. J. Hematol.
    Satherley et al., 2000, Relationship between expression of topoisomerase II isoforms and chemosensitivity in choroidal melanoma., J. Pathol.
    Hasinoff et al., 2001, The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells., Mol. Pharmacol.
    Langer et al., 2001, Dexrazoxane is a potent and specific inhibitor of anthracycline induced subcutaneous lesions in mice., Ann. Oncol.
    Hasinoff et al., 2002, The doxorubicin cardioprotective agent dexrazoxane (ICRF-187) induces endopolyploidy in rat neonatal myocytes through inhibition of DNA topoisomerase II., Anticancer Drugs
    Hasinoff et al., 2007, Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug?, Cardiovasc. Toxicol.
    Kik et al., 2006, [Dexrazoxane (ICRF-187)--a cardioprotectant and modulator of action of some anticancer drugs]., Postepy Hig Med Dosw (Online)
    Hasinoff et al., 1999, The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis., Anticancer Drugs
    Renodon-Cornière et al., 2003, Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance., Biochemistry
    Hasinoff et al., 2000, The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces endopolyploidy in Chinese hamster ovary cells., J. Pharmacol. Exp. Ther.
    López-Lázaro et al., 2005, Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients., J. Nat. Prod.
    Moneypenny et al., 2006, MLL rearrangements are induced by low doses of etoposide in human fetal hematopoietic stem cells., Carcinogenesis
    Nitiss et al., 1998, The bis(naphthalimide) DMP-840 causes cytotoxicity by its action against eukaryotic topoisomerase II., Biochemistry
    Asano et al., 1996, Transfection of human topoisomerase II alpha into etoposide-resistant cells: transient increase in sensitivity followed by down-regulation of the endogenous gene., Biochem. J.
    Asano et al., 1996, Transfection of a human topoisomerase II alpha gene into etoposide-resistant human breast tumor cells sensitizes the cells to etoposide., Oncol. Res.
    Negi A et al., 2015, Imine/amide-imidazole conjugates derived from 5-amino-4-cyano-N1-substituted benzyl imidazole: Microwave-assisted synthesis and anticancer activity via selective topoisomerase-II-α inhibition., Bioorg Med Chem
    Zhang X et al., 2013, The discovery and optimization of novel dual inhibitors of topoisomerase II and histone deacetylase., Bioorg Med Chem
    Chee GL et al., 2010, A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II., Bioorg Med Chem
    Chaniyara R et al., 2013, Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition., J Med Chem
    de Oliveira Figueiredo P et al., 2014, Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIα by its cytotoxic β-carboline alkaloids., Bioorg Med Chem Lett
    Li YB et al., 2013, Discovery, synthesis and biological evaluation of cycloprotoberberine derivatives as potential antitumor agents., Eur J Med Chem
    Shankaraiah N et al., 2015, One-pot synthesis of podophyllotoxin-thiourea congeners by employing NH₂SO₃H/NaI: Anticancer activity, DNA topoisomerase-II inhibition, and apoptosis inducing agents., Bioorg Med Chem Lett
    Liu LP et al., 2014, Topoisomerase II inhibitors from the roots of Stellera chamaejasme L., Bioorg Med Chem
    Zhao W et al., 2014, A rational design strategy of the novel topoisomerase II inhibitors for the synthesis of the 4-O-(2-pyrazinecarboxylic)-4'-demethylepipodophyllotoxin with antitumor activity by diminishing the relaxation reaction of topoisomerase II-DNA decatenation., Bioorg Med Chem
    Tan S et al., 2013, Oxo-heterocyclic fused naphthalimides as antitumor agents: synthesis and biological evaluation., Eur J Med Chem
    Yadav AA et al., 2015, Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs., Bioorg Med Chem
    Chen W et al., 2014, Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents., Eur J Med Chem
    Kamal A et al., 2012, Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents., Bioorg Med Chem
    Qiu J et al., 2015, Synthesis, biological evaluation and modeling studies of terphenyl topoisomerase IIα inhibitors as anticancer agents., Eur J Med Chem
    Hajbi Y et al., 2010, Synthesis and biological activities of new furo[3,4-b]carbazoles: potential topoisomerase II inhibitors., Eur J Med Chem
    Chen TC et al., 2015, Structure-based hybridization, synthesis and biological evaluation of novel tetracyclic heterocyclic azathioxanthone analogues as potential antitumor agents., Eur J Med Chem
    Oppegard LM et al., 2012, Inhibition of human topoisomerases I and II by simocyclinone D8., J Nat Prod
    He S et al., 2015, Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors., ACS Med Chem Lett
    Genès C et al., 2011, Synthesis and biological evaluation of N-substituted benzo[c]phenanthrolines and benzo[c]phenanthrolinones as antiproliferative agents., Eur J Med Chem
    Baviskar AT et al., 2015, Switch in Site of Inhibition: A Strategy for Structure-Based Discovery of Human Topoisomerase IIα Catalytic Inhibitors., ACS Med Chem Lett
    Aleksić M et al., 2014, Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties., Eur J Med Chem
    Lemster T et al., 2009, Photochemical electrocyclisation of 3-vinylindoles to pyrido[2,3-a]-, pyrido[4,3-a]- and thieno[2,3-a]-carbazoles: design, synthesis, DNA binding and antitumor cell cytotoxicity., Eur J Med Chem
    Hasinoff et al., 2008, The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds., Bioorg. Med. Chem.
    Hao H et al., 2015, Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents., Eur J Med Chem
    Baviskar AT et al., 2011, N-fused imidazoles as novel anticancer agents that inhibit catalytic activity of topoisomerase IIα and induce apoptosis in G1/S phase., J Med Chem
    Zhou Y et al., 2013, Synthesis, cytotoxicity and topoisomerase II inhibitory activity of lomefloxacin derivatives., Bioorg Med Chem Lett
    Kamal A et al., 2015, Design and synthesis of dithiocarbamate linked β-carboline derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability., Bioorg Med Chem
    Wang MJ et al., 2014, Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents., J Med Chem
    Furbacher TR et al., 2001, Catalytic inhibition of topoisomerase IIalpha by demethylzeylasterone, a 6-oxophenolic triterpenoid from Kokoona zeylanica., J Nat Prod
    Baviskar AT et al., 2013, Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity., Bioorg Med Chem
    Huang ZH et al., 2013, Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors., Eur J Med Chem
    Aleksić M et al., 2012, Novel substituted benzothiophene and thienothiophene carboxanilides and quinolones: synthesis, photochemical synthesis, DNA-binding properties, antitumor evaluation and 3D-derived QSAR analysis., J Med Chem
    Ashour A et al., 2014, Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs., Bioorg Med Chem
    Bar FM et al., 2009, Rational design and semisynthesis of betulinic acid analogues as potent topoisomerase inhibitors., J Nat Prod
    Mariani A et al., 2015, Differential Targeting of Human Topoisomerase II Isoforms with Small Molecules., J Med Chem
    Dunlap N et al., 2014, Synthesis and evaluation of ether-linked demethylepipodophyllotoxin dimers., Bioorg Med Chem Lett
    Dong G et al., 2012, New tricks for an old natural product: discovery of highly potent evodiamine derivatives as novel antitumor agents by systemic structure-activity relationship analysis and biological evaluations., J Med Chem
    Su TL et al., 2006, Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity., J Med Chem
    Liu JF et al., 2013, Synthesis and cytotoxic activity on human cancer cells of carbamate derivatives of 4β-(1,2,3-triazol-1-yl)podophyllotoxin., Eur J Med Chem
    Wada S et al., 2001, Screening of triterpenoids isolated from Phyllanthus flexuosus for DNA topoisomerase inhibitory activity., J Nat Prod
    Zhou et al., 1999, Topoisomerase II-mediated alterations of K562 drug resistant sublines., Med. Oncol.
    Willmore et al., 2002, Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells., Biochem. Pharmacol.
    De Renzo et al., 1999, Acute promyelocytic leukemia after treatment for non-Hodgkin's lymphoma with drugs targeting topoisomerase II., Am. J. Hematol.
    Bigioni et al., 1994, Base mutation analysis of topoisomerase II-idarubicin-DNA ternary complex formation. Evidence for enzyme subunit cooperativity in DNA cleavage., Nucleic Acids Res.
    González-Cid et al., 2002, Correlation between chromosome damage and apoptosis induced by fludarabine and idarubicin in normal human lymphocytes., Toxicology
    Tselepi M et al., 2011, Catalytic inhibition of eukaryotic topoisomerases I and II by flavonol glycosides extracted from Vicia faba and Lotus edulis., J Nat Prod
    Van Quaquebeke E et al., 2007, 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity., J Med Chem
    Terada et al., 1992, Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents., Chem. Pharm. Bull.
    Zhang et al., 1992, Antitumor agents, 130, Novel 4 beta-arylamino derivatives of 3',4'-didemethoxy-3',4'-dioxo-4-deoxypodophyllotoxin as potent inhibitors of human DNA topoisomerase II., J. Nat. Prod.
    Kamal et al., 2005, Synthesis and biological evaluation of new 4beta-anilino- and 4beta-imido-substituted podophyllotoxin congeners., Bioorg. Med. Chem.
    Iida et al., 2000, Podophyllotoxin aza-analogue, a novel DNA topoisomerase II inhibitor., Chem. Pharm. Bull.
    Ruckdeschel, 1991, Etoposide in the management of non-small cell lung cancer., Cancer
    Quintana-Espinoza P et al., 2013, Synthesis and study of antiproliferative, antitopoisomerase II, DNA-intercalating and DNA-damaging activities of arylnaphthalimides., Bioorg Med Chem
    Nitiss et al., 1992, Amsacrine and etoposide hypersensitivity of yeast cells overexpressing DNA topoisomerase II., Cancer Res.
    Finlay et al., 1999, Inhibition of the action of the topoisomerase II poison amsacrine by simple aniline derivatives: evidence for drug-protein interactions., Oncol. Res.
    Arimondo et al., 2000, Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity., Anticancer Drug Des.
    Ferlin et al., 2000, Synthesis and antiproliferative activity of some variously substituted acridine and azacridine derivatives., Eur J Med Chem
    Matsumoto et al., 2001, Hypophosphorylation of topoisomerase IIalpha in etoposide (VP-16)-resistant human carcinoma cell lines associated with carboxy-terminal truncation., Jpn. J. Cancer Res.
    Lee et al., 1992, Two independent amsacrine-resistant human myeloid leukemia cell lines share an identical point mutation in the 170 kDa form of human topoisomerase II., J. Mol. Biol.
    Dalla Via L et al., 2009, Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties., J Med Chem
    Dalla Via L et al., 2012, A novel tetrahydrobenzoangelicin with dark and photo biological activity., Bioorg Med Chem
    Christodoulou MS et al., 2015, Boehmeriasin A as new lead compound for the inhibition of topoisomerases and SIRT2., Eur J Med Chem
    Dalla Via L et al., 2009, DNA-targeting pyrroloquinoline-linked butenone and chalcones: synthesis and biological evaluation., Eur J Med Chem
    Diana P et al., 2007, 3,5-bis(3'-indolyl)pyrazoles, analogues of marine alkaloid nortopsentin: synthesis and antitumor properties., Bioorg Med Chem Lett
    Rene et al., 1996, The 1'-substituent on the anilino ring of the antitumor drug amsacrine is a critical element for topoisomerase II inhibition and cytotoxicity., Mol. Pharmacol.
    Houlbrook et al., 1995, Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines., Br. J. Cancer
    Nair et al., Differential effect of camptothecin treatment on topoisomerase II alpha expression in ML-1 and HL-60 leukemia cell lines., Anticancer Res.
    Ferri N et al., 2011, Synthesis, structural, and biological evaluation of bis-heteroarylmaleimides and bis-heterofused imides., Bioorg Med Chem
    Perabo et al., 2005, New agents in intravesical chemotherapy of superficial bladder cancer., Scand. J. Urol. Nephrol.
    Zahir A et al., 1996, DNA topoisomerase I inhibitors: cytotoxic flavones from Lethedon tannaensis., J Nat Prod
    Constantinou A et al., 1995, Flavonoids as DNA topoisomerase antagonists and poisons: structure-activity relationships., J Nat Prod
    Chawla SP et al., 2015, A phase 1B/2 study of aldoxorubicin in patients with soft tissue sarcoma., Cancer
    Song G et al., 2010, Synthesis and biological evaluation of cytotoxic activity of novel anthracene L-rhamnopyranosides., Bioorg Med Chem
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Baechler SA et al., 2013, Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs., Bioorg Med Chem
    Du L et al., 2011, Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase IIα inhibitor., J Med Chem
    Lindsey et al., 2005, Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison., Chem. Res. Toxicol.
    Zeglis BM et al., 2011, Role of metalation in the topoisomerase IIα inhibition and antiproliferation activity of a series of α-heterocyclic-N4-substituted thiosemicarbazones and their Cu(II) complexes., J Med Chem
    Casu L et al., 2011, Ungeremine effectively targets mammalian as well as bacterial type I and type II topoisomerases., Bioorg Med Chem Lett
  • AMONAFIDE   TOP2A

    Interaction Score: 2.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name amonafide,Quinamed
    Novel drug target Established target

    PMIDs:
    26211460 23353750 20170164 24054489 17658777


    Sources:
    DTC TdgClinicalTrial

  • CHEMBL607534   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • CHEMBL594259   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • UNGEREMINE   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014547


    Sources:
    DTC

  • CHEMBL507986   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21391686


    Sources:
    DTC

  • LUPEOL   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754608


    Sources:
    DTC

  • DIAZIRINE   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20006518


    Sources:
    DTC

  • HURATOXIN   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24931277


    Sources:
    DTC

  • CHEMBL596082   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • OLEANDEROLIDE   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24326278


    Sources:
    DTC

  • TRICITRINOL B   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21761866


    Sources:
    DTC

  • CHEMBL594257   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • CHEMBL594153   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • MAKALUVAMINE E   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8691207


    Sources:
    DTC

  • CHEMBL2023733   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22276998


    Sources:
    DTC

  • FRANGULIN B   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20561793


    Sources:
    DTC

  • MAKALUVAMINE F   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8691207


    Sources:
    DTC

  • CHEMBL593570   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • CHEMBL594379   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • CHEMBL594695   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19783445


    Sources:
    DTC

  • DEMETHYLZEYLASTERONE   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11678653


    Sources:
    DTC

  • MAKALUVAMINE A   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8691207


    Sources:
    DTC

  • ELINAFIDE   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21880496


    Sources:
    DTC

  • CHEMBL1080077   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19691293


    Sources:
    DTC

  • CHEMBL244268   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17658777


    Sources:
    DTC

  • KAEMPFERITRIN   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22014228


    Sources:
    DTC

  • BETULIN   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11754608


    Sources:
    DTC

  • 4'-O-ACETYLPATENTIFLORIN B   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22119124


    Sources:
    DTC

  • MAKALUVAMINE C TFA SALT   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8691207


    Sources:
    DTC

  • CHEMBL1773343   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21489802


    Sources:
    DTC

  • AMRUBICIN   TOP2A

    Interaction Score: 1.55

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor

    PMIDs:
    17628745


    Sources:
    ChemblInteractions

  • VALRUBICIN   TOP2A

    Interaction Score: 1.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes
    Trial Name -

    PMIDs:
    16019763 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • DEXRAZOXANE   TOP2A

    Interaction Score: 1.29

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    11179439 11332155 11984069 17652819 17115008 10194547 12911317 11046078 11752352


    Sources:
    NCI

  • ALDOXORUBICIN   TOP2A

    Interaction Score: 1.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name INNO-206
    Novel drug target Established target
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor

    PMIDs:
    25312684


    Sources:
    TdgClinicalTrial ChemblInteractions

  • TENIPOSIDE   TOP2A

    Interaction Score: 1.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -
    Mechanism of Interaction DNA topoisomerase II inhibitor

    PMIDs:
    9426516 8702194 16480143 16271071 17514873 11752352 17361331


    Sources:
    TdgClinicalTrial ChemblInteractions NCI TEND

  • AMSACRINE   TOP2A

    Interaction Score: 0.88

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    1322791 10691026 11716434 11752352 11006484 11473732 1311390 19725581 22537681 25626146 19155103 17911018 8823806 8632768 8519659


    Sources:
    DTC NCI

  • ETOPOSIDE   TOP2A

    Interaction Score: 0.85

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction DNA topoisomerase II inhibitor
    Trial Name -

    PMIDs:
    16271071 17514873 11752352 16309315 16377807 17361331 9494516 9485461 9426516 8870683 8823806 26216018 24095018 20006518 23360284 24507920 24012683 26292628 18816045 24931277 24775914 23353750 25922181 25240702 22364746 25800514 20863598 25799376 22867097 25815139 21435753 25941559 24334150 19386396 18258442 26291037 21644529 23566520 19783445 26264845 25003995 11678653 23920485 23968711 22620261 24326278 19691293 25945730 25466187 22867019 16759114 23711769


    Sources:
    DTC TdgClinicalTrial ChemblInteractions NCI TEND

  • SIMOCYCLINONE D8   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22867097


    Sources:
    DTC

  • AMRUBICIN HYDROCHLORIDE   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • SECAUBRYOLIDE   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • 13-DEOXYDOXORUBICIN   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name GPX-100
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • CHEMBL2171812   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22867019


    Sources:
    DTC

  • CHEMBL2332128   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2332126   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CHEMBL2171794   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22867019


    Sources:
    DTC

  • CHEMBL2171781   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22867019


    Sources:
    DTC

  • CHEMBL2332127   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DAUNORUBICIN CITRATE   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CARINATIN G   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • VOSAROXIN   TOP2A

    Interaction Score: 0.77

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Voreloxin
    Novel drug target Established target
    Mechanism of Interaction DNA topoisomerase II inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • LYCOBETAINE   TOP2A

    Interaction Score: 0.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23266176


    Sources:
    DTC

  • BECATECARIN   TOP2A

    Interaction Score: 0.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name becatecarin, XL 119, rebeccamycin
    Novel drug target Established target
    Mechanism of Interaction DNA topoisomerase II inhibitor

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • DIPHYLLIN   TOP2A

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22119124


    Sources:
    DTC

  • BERUBICIN HYDROCHLORIDE   TOP2A

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • GANCOTAMAB   TOP2A

    Interaction Score: 0.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • C-1311   TOP2A

    Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction DNA topoisomerase II inhibitor
    Trial Name C-1311, XLS-002,Symadex

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial ChemblInteractions

  • PODOFILOX   TOP2A

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    1334447 1331331 11752352 16061385 10783066 1845848


    Sources:
    TdgClinicalTrial TEND

  • MITOXANTRONE   TOP2A

    Interaction Score: 0.21

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name liposome encapsulated mitoxantrone (LEM)
    Novel drug target Established target
    Trial Name mitoxantrone hydrochloride,Novantrone

    PMIDs:
    9494516 9426516 18687447 10451375 11278845 11752352 9631585 11004693


    Sources:
    TdgClinicalTrial NCI TEND

  • IDRONOXIL   TOP2A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial

  • IDARUBICIN   TOP2A

    Interaction Score: 0.17

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name -
    Novel drug target Established target

    PMIDs:
    10523799 12034365 10203104 8036155 11752352 11836027


    Sources:
    TdgClinicalTrial TEND

  • EPIRUBICIN   TOP2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    14728934 17639997 16234514


    Sources:
    TdgClinicalTrial TEND PharmGKB

  • FISETIN   TOP2A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8759170


    Sources:
    DTC

  • DOXORUBICIN   TOP2A

    Interaction Score: 0.12

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name AEZS-108, AN-152
    Novel drug target Established target
    Trial Name MTC-DOX, MTC-doxorubicin

    PMIDs:
    21388138 26211460 22276998 20170164 17016621 17351394 17010609 17578914 11752352 17089011


    Sources:
    DTC TdgClinicalTrial ClearityFoundationClinicalTrial TEND

  • ETOPOSIDE PHOSPHATE   TOP2A

    Interaction Score: 0.11

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • HYDROQUINONE   TOP2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15833037


    Sources:
    NCI

  • DIGITOXIN   TOP2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16309315


    Sources:
    DTC

  • DAUNORUBICIN   TOP2A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Novel drug target Established target
    Trial Name CPX-351, cytarabine + daunorubicin

    PMIDs:
    6380596 1963303 9494516 22260166


    Sources:
    DTC TdgClinicalTrial NCI

  • ADRIAMYCIN   TOP2A

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9494516


    Sources:
    NCI

  • ELLIPTECINE   TOP2A

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18816045 19783445


    Sources:
    DTC

  • GENISTEIN   TOP2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17016423 17139284 7769390


    Sources:
    DTC

  • MYRICETIN   TOP2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8759170 7769390


    Sources:
    DTC

  • IDARUBICIN HYDROCHLORIDE   TOP2A

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CAMPTOTHECIN   TOP2A

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11205246


    Sources:
    NCI

  • QUERCETIN   TOP2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8759170 7769390


    Sources:
    DTC

  • VINCRISTINE   TOP2A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9494516


    Sources:
    NCI

  • MITOXANTRONE HYDROCHLORIDE   TOP2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DAUNORUBICIN HYDROCHLORIDE   TOP2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DOXORUBICIN HYDROCHLORIDE   TOP2A

    Interaction Score: 0.02

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction DNA topoisomerase II alpha inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • PACLITAXEL   TOP2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name liposomal encapsulated paclitaxel (LEP)
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • FLUOROURACIL   TOP2A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000131747

    • Version: 101_38

    Alternate Names:
    TOP2A Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000131747

    • Version: 26-July-2011

    Alternate Names:
    Q71UN1_HUMAN Display Id
    TOPOISOMERASE II ALPHA (FRAGMENT). [SOURCE:UNIPROT/SPTREMBL;ACC:Q71UQ5] Description
    ENSG00000131747 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TEND: P11388

    • Version: 01-August-2011

    Alternate Names:
    P11388 Uniprot Accession
    ENSG00000131747 Ensembl Gene Id
    TOP2A_HUMAN Uniprot Id

    Gene Info:
    Target Subclass 5.99.1.3
    Target Main Class Enzymes

    Publications:

  • TdgClinicalTrial: P11388

    • Version: January-2014

    Alternate Names:
    TOP2A Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:5.99.1.3

    Publications:

  • HopkinsGroom: P11388

    • Version: 11-September-2012

    Alternate Names:
    P11388 Uniprot Accession
    7153 Entrez Gene Id
    TOP2A Uniprot Gene Name

    Gene Info:
    Interpro Name DNA topoisomerase, type IIA
    Interpro Type Domain
    Interpro Short Name Topo_IIA

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: TOP2A

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    McPherson et al., Selective sensitization of adriamycin-resistant P388 murine leukemia cells to antineoplastic agents following transfection with human DNA topoisomerase II alpha., Anticancer Res.
    Renodon-Cornière et al., 2003, Analysis of bisdioxopiperazine dexrazoxane binding to human DNA topoisomerase II alpha: decreased binding as a mechanism of drug resistance., Biochemistry
    Mueller et al., 2004, Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples., Genes Chromosomes Cancer

  • DTC: TOP2A

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Schmidt EW et al., 1995, Makaluvamines H-M and damirone C from the pohnpeian sponge Zyzzya fuliginosa., J Nat Prod
    Van Quaquebeke E et al., 2007, 2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity., J Med Chem
    Dalla Via L et al., 2009, DNA-targeting pyrroloquinoline-linked butenone and chalcones: synthesis and biological evaluation., Eur J Med Chem

  • ChemblInteractions: TOP2

    • Version: chembl_23

    Alternate Names:
    TOP2 GENE_SYMBOL
    TOP2A GENE_SYMBOL
    DNA topoisomerase 2-alpha UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000131747

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000131747 Gene Symbol
    TOP2A Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: TOP2A

    • Version: 18-August-2020

    Alternate Names:
    PA354 PharmGKB ID

    Gene Info:

    Publications:

  • Tempus: TOP2A

    • Version: 11-November-2018

    Alternate Names:
    TOP2A Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • TTD: DNA topoisomerase II alpha

    • Version: 2020.06.01

    Alternate Names:
    TOP2A TTD Gene Abbreviation
    T17048 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: TOP2A

    • Version: 01-February-2022

    Alternate Names:
    DNA topoisomerase 2-alpha Gene Name
    P11388 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • ClearityFoundationBiomarkers: TOP2A

    • Version: 26-July-2013

    Alternate Names:

    Gene Info:

    Publications:

  • ClearityFoundationClinicalTrial: TOP2A

    • Version: 15-June-2013

    Alternate Names:

    Gene Info:

    Publications:

  • MskImpact: TOP2A

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21