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TNFRSF1B Gene Record

  • Summary
  • Interactions
  • Claims
  • TNFRSF1B 7133 Druggable Genome

    Alternate Names:

    7133
    TNF RECEPTOR SUPERFAMILY MEMBER 1B
    TNFRSF1B
    CD120b
    TBPII
    TNF-R-II
    TNF-R75
    TNFBR
    TNFR1B
    TNFR2
    TNFR80
    p75
    p75TNFR
    191191
    11917
    ENSG00000028137
    OTTHUMG00000001829
    P20333
    PA36610

    Gene Info:

    Target Class Miscellaneous
    Target Subclass Miscellaneous
    Target Subclass TNF
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Himmerich et al., 2005, Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium., Psychopharmacology (Berl.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Xing-Rong W et al., 2018, Role of TNFRSF1A and TNFRSF1B polymorphisms in susceptibility, severity, and therapeutic efficacy of etanercept in human leukocyte antigen-B27-positive Chinese Han patients with ankylosing spondylitis., Medicine (Baltimore)
    Canet LM et al., 2015, Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study., Pharmacogenet Genomics
    González-Lara L et al., 2015, The TNFRSF1B rs1061622 polymorphism (p.M196R) is associated with biological drug outcome in Psoriasis patients., Arch Dermatol Res
    Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine
    Rooryck C et al., 2008, Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy., Clin Exp Rheumatol
    Nokta et al., 1997, Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea., AIDS Res. Hum. Retroviruses
  • INFLIXIMAB   TNFRSF1B

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25850964 25537528 22129793 18565259


    Sources:
    PharmGKB

  • DIDANOSINE   TNFRSF1B

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430255


    Sources:
    NCI

  • ETANERCEPT   TNFRSF1B

    Interaction Score: 1.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11752352 30075559


    Sources:
    PharmGKB

  • STAVUDINE   TNFRSF1B

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430255


    Sources:
    NCI

  • LITHIUM   TNFRSF1B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15565432


    Sources:
    NCI

  • CARBAMAZEPINE   TNFRSF1B

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15565432


    Sources:
    NCI

  • Ensembl: ENSG00000028137

    • Version: 101_38

    Alternate Names:
    TNFRSF1B Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TdgClinicalTrial: P20333

    • Version: January-2014

    Alternate Names:
    TNFRSF1B Gene Symbol

    Gene Info:
    Target Class Miscellaneous
    Target Subclass Miscellaneous
    Target Subclass TNF

    Publications:

  • PharmGKB: TNFRSF1B

    • Version: 18-August-2020

    Alternate Names:
    PA36610 PharmGKB ID

    Gene Info:

    Publications:
    Canet LM et al., 2015, Genetic variants within the TNFRSF1B gene and susceptibility to rheumatoid arthritis and response to anti-TNF drugs: a multicenter study., Pharmacogenet Genomics
    Rooryck C et al., 2008, Influence of FCGR3A-V212F and TNFRSF1B-M196R genotypes in patients with rheumatoid arthritis treated with infliximab therapy., Clin Exp Rheumatol
    González-Lara L et al., 2015, The TNFRSF1B rs1061622 polymorphism (p.M196R) is associated with biological drug outcome in Psoriasis patients., Arch Dermatol Res

  • NCI: TNFRSF1B

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Nokta et al., 1997, Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea., AIDS Res. Hum. Retroviruses
    Pelagi et al., 2000, Caspase inhibition reveals functional cooperation between p55- and p75-TNF receptors in cell necrosis., Eur. Cytokine Netw.
    Himmerich et al., 2005, Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium., Psychopharmacology (Berl.)

  • HingoraniCasas: ENSG00000028137

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000028137 Gene Symbol
    TNFRSF1B Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21