DGIdb - TNF Gene Record

TNF 7124 Druggable Genome

Alternate Names:

7124
TUMOR NECROSIS FACTOR
TNF
DIF
TNF-alpha
TNFA
TNFSF2
TNLG1F
191160
11892
ENSG00000232810
OTTHUMG00000031194
P01375
TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 2
CACHECTIN
TNF-A
ENSG00000204490; ENSG00000206439; ENSG00000228321; ENSG00000228849; ENSG00000230108; ENSG00000223952; ENSG00000232810
N-terminal fragment
Tumor necrosis factor, soluble form
C-domain 2
C-domain 1
Intracellular domain 2
Intracellular domain 1
Tumor necrosis factor, membrane form
ICD2
ICD1
NTF
PA435
TNFA_HUMAN
T20178

Gene Info:

Target Class	Miscellaneous
Target Subclass	Ligand
Target Subclass	Cytokine
Target Class	Other
Target Main Class	Other
Transmembrane Helix Count	1
Gene Biotype	PROTEIN_CODING

(9 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.
Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology
Kim SH et al., 2012, TNF-α genetic polymorphism -308G/A and antituberculosis drug-induced hepatitis., Liver Int
Vincent, 2000, Afelimomab., Int. J. Clin. Pract.
Mimura, 2007, [Selection of one of the TNF blockers; infliximab and etanercept]., Nippon Rinsho
Magro et al., 2005, Reactive hepatitis in a patient with Crohn's disease successfully treated with infliximab: does tumor necrosis factor alpha play a role in reactive hepatitis?, Inflamm. Bowel Dis.
Sapienza et al., 2004, Treatment of pyoderma gangrenosum with infliximab in Crohn's disease., Dig. Dis. Sci.
Shen et al., 2005, Adalimumab induces apoptosis of human monocytes: a comparative study with infliximab and etanercept., Aliment. Pharmacol. Ther.
Braun et al., 2005, Decreased incidence of anterior uveitis in patients with ankylosing spondylitis treated with the anti-tumor necrosis factor agents infliximab and etanercept., Arthritis Rheum.
Mori et al., 2006, Pneumocystis jiroveci pneumonia in a patient with rheumatoid arthritis as a complication of treatment with infliximab, anti-tumor necrosis factor alpha neutralizing antibody., Mod Rheumatol
Maini et al., 2002, How does infliximab work in rheumatoid arthritis?, Arthritis Res.
Popa et al., 2005, Cytokine production of stimulated whole blood cultures in rheumatoid arthritis patients receiving short-term infliximab therapy., Cytokine
Tobin et al., 2005, TNF alpha inhibitors in the treatment of psoriasis and psoriatic arthritis., BioDrugs
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Danese et al., 2006, TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease., J. Immunol.
Song GG et al., 2015, Association between TNF-α (-308 A/G, -238 A/G, -857 C/T) polymorphisms and responsiveness to TNF-α blockers in spondyloarthropathy, psoriasis and Crohn's disease: a meta-analysis., Pharmacogenomics
Swierkot J et al., 2015, Analysis of associations between polymorphisms within genes coding for tumour necrosis factor (TNF)-alpha and TNF receptors and responsiveness to TNF-alpha blockers in patients with rheumatoid arthritis., Joint Bone Spine
Tong Q et al., 2013, Association of TNF-α polymorphism with prediction of response to TNF blockers in spondyloarthritis and inflammatory bowel disease: a meta-analysis., Pharmacogenomics
Tong Q et al., 2012, TNF-α -857 and -1031 polymorphisms predict good therapeutic response to TNF-α blockers in Chinese Han patients with ankylosing spondylitis., Pharmacogenomics
Lacruz-Guzmán D et al., 2013, Influence of polymorphisms and TNF and IL1β serum concentration on the infliximab response in Crohn's disease and ulcerative colitis., Eur J Clin Pharmacol
Zeng Z et al., 2013, Association between tumor necrosis factor-α (TNF-α) promoter -308 G/A and response to TNF-α blockers in rheumatoid arthritis: a meta-analysis., Mod Rheumatol
Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine
O'Rielly DD et al., 2009, TNF-alpha-308 G/A polymorphism and responsiveness to TNF-alpha blockade therapy in moderate to severe rheumatoid arthritis: a systematic review and meta-analysis., Pharmacogenomics J
Maxwell JR et al., 2008, Association of the tumour necrosis factor-308 variant with differential response to anti-TNF agents in the treatment of rheumatoid arthritis., Hum Mol Genet
Marotte H et al., 2008, Association between the level of circulating bioactive tumor necrosis factor alpha and the tumor necrosis factor alpha gene polymorphism at -308 in patients with rheumatoid arthritis treated with a tumor necrosis factor alpha inhibitor., Arthritis Rheum
Guis S et al., 2007, Influence of -308 A/G polymorphism in the tumor necrosis factor alpha gene on etanercept treatment in rheumatoid arthritis., Arthritis Rheum
Miceli-Richard C et al., 2008, A single tumour necrosis factor haplotype influences the response to adalimumab in rheumatoid arthritis., Ann Rheum Dis
Cuchacovich M et al., 2006, Tumour necrosis factor (TNF)alpha -308 G/G promoter polymorphism and TNFalpha levels correlate with a better response to adalimumab in patients with rheumatoid arthritis., Scand J Rheumatol
Lee YH et al., 2006, Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis., Rheumatol Int
Seitz M et al., 2007, The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients., Rheumatology (Oxford)
Kang et al., 2005, The influence of a polymorphism at position -857 of the tumour necrosis factor alpha gene on clinical response to etanercept therapy in rheumatoid arthritis., Rheumatology (Oxford)
Mugnier B et al., 2003, Polymorphism at position -308 of the tumor necrosis factor alpha gene influences outcome of infliximab therapy in rheumatoid arthritis., Arthritis Rheum
Louis E et al., 2002, A positive response to infliximab in Crohn disease: association with a higher systemic inflammation before treatment but not with -308 TNF gene polymorphism., Scand J Gastroenterol
Friedland et al., 1993, Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental Escherichia coli meningitis., J. Infect. Dis.
Bessler et al., 2000, Effect of cefotaxime on cytokine production in newborns and adults in vitro., Biomed. Pharmacother.
Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J
Lü et al., 2004, [Effect of clozapine and risperidone on serum cytokine levels in patients with first-episode paranoid schizophrenia]., Di Yi Jun Yi Da Xue Xue Bao
Erbağci et al., 2001, Serum IL-1beta, sIL-2R, IL-6, IL-8 and TNF-alpha in schizophrenic patients, relation with symptomatology and responsiveness to risperidone treatment., Mediators Inflamm.
Bang et al., 2004, Adalimumab: a review of its use in rheumatoid arthritis., BioDrugs
Aguillón et al., 2003, [New immunological weapons for medicine in the 21st Century: biological therapy based on the use of the latest generation monoclonal antibodies]., Rev Med Chil
Klinkhoff, 2004, Biological agents for rheumatoid arthritis: targeting both physical function and structural damage., Drugs
Flendrie et al., 2003, Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis., Ann. Rheum. Dis.
Lorenz, 2002, Technology evaluation: adalimumab, Abbott laboratories., Curr. Opin. Mol. Ther.
Rajkumar, 2001, Thalidomide in the treatment of multiple myeloma., Expert Rev Anticancer Ther
Enomoto et al., 2002, Thalidomide prevents alcoholic liver injury in rats through suppression of Kupffer cell sensitization and TNF-alpha production., Gastroenterology
Vescovo et al., 2002, Effect of thalidomide on the skeletal muscle in experimental heart failure., Eur. J. Heart Fail.
Turk et al., 1996, Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production., Proc. Natl. Acad. Sci. U.S.A.
Fu et al., 2002, Thalidomide and tuberculosis., Int. J. Tuberc. Lung Dis.
Richardson et al., 2002, Thalidomide in multiple myeloma., Biomed. Pharmacother.
Sugimoto et al., 2006, Influences of proinflammatory and anti-inflammatory cytokine polymorphisms on eradication rates of clarithromycin-sensitive strains of Helicobacter pylori by triple therapy., Clin. Pharmacol. Ther.
Park et al., 1999, Structural basis for self-association and receptor recognition of human TRAF2., Nature
Calabrese, 1999, Rheumatoid arthritis and primary care: the case for early diagnosis and treatment., J Am Osteopath Assoc
Sandborn et al., 1999, Antitumor necrosis factor therapy for inflammatory bowel disease: a review of agents, pharmacology, clinical results, and safety., Inflamm. Bowel Dis.
Moreland, 1999, Inhibitors of tumor necrosis factor: new treatment options for rheumatoid arthritis., Cleve Clin J Med
Grell et al., 1999, Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF-R1 activation by endogenous membrane-anchored TNF., EMBO J.
Liu, 1993, Expression of tumor necrosis factor and c-fos genes in peritoneal macrophages of hypothyroid mice., Inflammation
Pirmohamed M et al., 2001, TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients., Neurology
Himmerich et al., 2005, Plasma levels of leptin and endogenous immune modulators during treatment with carbamazepine or lithium., Psychopharmacology (Berl.)
Peng et al., 2001, Effects of early enteral feeding on the prevention of enterogenic infection in severely burned patients., Burns
Pérez-Castrillón JL et al., 2008, Effect of the TNFalpha-308 G/A polymorphism on the changes produced by atorvastatin in bone mineral density in patients with acute coronary syndrome., Ann Nutr Metab
Mittal et al., Golimumab and certolizumab: the two new anti-tumor necrosis factor kids on the block., Indian J Dermatol Venereol Leprol
Oettinger et al., 2003, Microencapsulation of tumor necrosis factor oligomers: a new approach to proinflammatory cytokine inhibition., J. Interferon Cytokine Res.
Natsume et al., 2002, Enhanced antitumor activities of TZT-1027 against TNF-alpha or IL-6 secreting Lewis lung carcinoma in vivo., Cancer Chemother. Pharmacol.
Lee JH et al., 2013, Genetic predisposition of hand-foot skin reaction after sorafenib therapy in patients with hepatocellular carcinoma., Cancer
Zhang et al., 1999, Effects of bacillus Calmette-Guèrin and interferon alpha-2B on cytokine production in human bladder cancer cell lines., J. Urol.
Shin et al., 2002, Effects of rutin and harmaline on rat reflux oesophagitis., Auton Autacoid Pharmacol
Manna et al., 1999, Suppression of tumor necrosis factor-activated nuclear transcription factor-kappaB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by beta-lapachone., Biochem. Pharmacol.
Beloeil et al., 2005, Bupivacaine's action on the carrageenan-induced inflammatory response in mice: cytokine production by leukocytes after ex-vivo stimulation., Anesth. Analg.
Ventre et al., 1997, Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice., Diabetes
Reinehr et al., 2005, High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children., Metab. Clin. Exp.
Leiba et al., 2006, Halofuginone inhibits NF-kappaB and p38 MAPK in activated T cells., J. Leukoc. Biol.
Elias et al., 2004, Serum TNF-alpha in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene., BMC Dermatol.
Grinyó J et al., 2008, Association of four DNA polymorphisms with acute rejection after kidney transplantation., Transpl Int
Chew CS et al., 2011, Tumour necrosis factor haplotypes associated with sensory neuropathy in Asian and Caucasian human immunodeficiency virus patients., Tissue Antigens
Chiang et al., 2005, Pyridoxine supplementation corrects vitamin B6 deficiency but does not improve inflammation in patients with rheumatoid arthritis., Arthritis Res. Ther.
Zeisig et al., 1995, Influence of hexadecylphosphocholine on the release of tumor necrosis factor and nitroxide from peritoneal macrophages in vitro., J. Cancer Res. Clin. Oncol.
Nokta et al., 1997, Kinetics of tumor necrosis factor alpha and soluble TNFRII in HIV-infected patients treated with a triple combination of stavudine, didanosine, and hydroxyurea., AIDS Res. Hum. Retroviruses
Miura et al., 2006, Anti-inflammatory effect of spironolactone on human peripheral blood mononuclear cells., J. Pharmacol. Sci.
Gogusev et al., Regulation of TNF-alpha and IL-1 gene expression during TPA-induced differentiation of "Malignant histiocytosis" DEL cell line t(5;6) (q35:p21)., Anticancer Res.
Mori et al., 2004, Comparison of the effects of glimepiride and glibenclamide on adipose tissue tumour necrosis factor-alpha mRNA expression and cellularity., Diabetes Obes Metab

GOLIMUMAB TNF

Interaction Score: 4.55

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
21079302

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
PLACULUMAB TNF

Interaction Score: 2.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ART621, PN0621

Novel drug target Established target

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD
OZORALIZUMAB TNF

Interaction Score: 1.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

Trial Name ozoralizumab

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
MEROPENEM TNF

Interaction Score: 1.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8354907

Sources:
NCI
PEGSUNERCEPT TNF

Interaction Score: 1.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD
AFELIMOMAB TNF

Interaction Score: 1.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
10829362

Sources:
ChemblInteractions
INFLIXIMAB TNF

Interaction Score: 1.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name infliximab ,Remicade

Novel drug target Established target

Direct Interaction yes

PMIDs:
17642244 15674127 15481318 15691299 16052578 16622728 12110154 15804598 15691217 11752352 16456024 26244882 25311255 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17673491 17343250 16909270 16720636 15695296 12847678 12190096

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
ADALIMUMAB TNF

Interaction Score: 1.39

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

Trial Name Humira

PMIDs:
26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096 15046527 15022409 15200343 14532145 11752352 12044041

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
ETANERCEPT TNF

Interaction Score: 1.24

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

Trial Name Enbrel

PMIDs:
10206649 10405518 10338381 10375846 11752352 10357816 26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD
LENABASUM TNF

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
SOBLIDOTIN TNF

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11855751

Sources:
NCI
LENERCEPT TNF

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
CERTOLIZUMAB TNF

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
NERELIMOMAB TNF

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ENBREL TNF

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CERTOLIZUMAB PEGOL TNF

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
AZ9773 TNF

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
ONERCEPT TNF

Interaction Score: 0.91

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
PYRIDOXINE TNF

Interaction Score: 0.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16277693

Sources:
NCI
REMTOLUMAB TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PF-04236921 TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PF-04236921

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ETHAMBUTOL TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22151084

Sources:
PharmGKB
LACTULOSE TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11226652

Sources:
NCI
ABBV-257 TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CEFOTAXIME TNF

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8354907 10989981

Sources:
NCI
MILTEFOSINE TNF

Interaction Score: 0.36

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7883777

Sources:
NCI
BENZO[E]PYRENE TNF

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
NAFAMOSTAT TNF

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
HALOFUGINONE TNF

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16769768

Sources:
NCI
THALIDOMIDE TNF

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name Thalomid

PMIDs:
12113124 12105857 12167383 8755512 11752352 12102294 12046682

Sources:
TdgClinicalTrial TEND TTD
5,7-DIHYDROXY-4-METHYLCOUMARIN TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLIMEPIRIDE TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14686960

Sources:
NCI
ORTATAXEL TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CELASTROL TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PYRAZINAMIDE TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22151084

Sources:
PharmGKB
DERSALAZINE TNF

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name dersalazine sodium

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
BUPIVACAINE TNF

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15781526

Sources:
NCI
RUTIN TNF

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12423426

Sources:
NCI
VADIMEZAN TNF

Interaction Score: 0.18

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC
HYDROXYCHLOROQUINE TNF

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9002011

Sources:
NCI
DIDANOSINE TNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430255

Sources:
NCI
BCG VACCINE TNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10022737

Sources:
NCI
RABEPRAZOLE TNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16815316

Sources:
NCI
ISONIAZID TNF

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22151084

Sources:
PharmGKB
AMPHOTERICIN B TNF

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAVUDINE TNF

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20887379

Sources:
PharmGKB
LENALIDOMIDE TNF

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial TTD
PROPYLTHIOURACIL TNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15119959

Sources:
NCI
METHYLENE BLUE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
METHIMAZOLE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8491516

Sources:
NCI
ALTEPLASE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8615653

Sources:
NCI
SPIRONOLACTONE TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16837769

Sources:
NCI
RIFAMPIN TNF

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22151084

Sources:
PharmGKB
GENTAMICIN TNF

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14565862

Sources:
NCI
CARBAMAZEPINE TNF

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11294926 15565432

Sources:
NCI PharmGKB
LAPACHONE TNF

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10075082

Sources:
NCI
OMEPRAZOLE TNF

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16815316

Sources:
NCI
INSULIN TNF

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9287059 16125526

Sources:
NCI
RISPERIDONE TNF

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15567770 11545247

Sources:
NCI
MIDAZOLAM TNF

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16406030

Sources:
NCI
HOMIDIUM BROMIDE TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ATORVASTATIN TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18997459

Sources:
PharmGKB
CYCLOSPORINE TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18444945

Sources:
PharmGKB
PENTOXIFYLLINE TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIGOXIN TNF

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CARBOPLATIN TNF

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31616045

Sources:
PharmGKB
SORAFENIB TNF

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22736425

Sources:
PharmGKB
GEMCITABINE TNF

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
31616045

Sources:
PharmGKB

Ensembl: ENSG00000232810
- Version: 101_38
Alternate Names:

TNF Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TEND: P01375
- Version: 01-August-2011
Alternate Names:

P01375 Uniprot Accession

ENSG00000204490; ENSG00000206439; ENSG00000228321; ENSG00000228849; ENSG00000230108; ENSG00000223952; ENSG00000232810 Ensembl Gene Id

TNF Gene Symbol

Gene Info:

Target Main Class Other

Target Subclass Ligand

Transmembrane Helix Count 1

Publications:
TdgClinicalTrial: P01375
- Version: January-2014
Alternate Names:

TNF Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Ligand

Target Subclass Cytokine

Publications:

PharmGKB: TNF

Version: 18-August-2020

Alternate Names:

PA435 PharmGKB ID

Gene Info:

Publications:

Björn N et al., 2020, Genes and variants in hematopoiesis-related pathways are associated with gemcitabine/carboplatin-induced thrombocytopenia., Pharmacogenomics J

Seitz M et al., 2007, The -308 tumour necrosis factor-alpha gene polymorphism predicts therapeutic response to TNFalpha-blockers in rheumatoid arthritis and spondyloarthritis patients., Rheumatology (Oxford)

Lee YH et al., 2006, Association of TNF-alpha -308 G/A polymorphism with responsiveness to TNF-alpha-blockers in rheumatoid arthritis: a meta-analysis., Rheumatol Int

TTD: Tumor necrosis factor

Version: 2020.06.01

Alternate Names:

TNF TTD Gene Abbreviation

T20178 TTD Target ID

Gene Info:

Publications:

Libutti SK et al., 2010, Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine., Clin Cancer Res

Assier E et al., 2012, Modulation of anti-tumor necrosis factor alpha (TNF-α) antibody secretion in mice immunized with TNF-α kinoid., Clin Vaccine Immunol

NCI: TNF

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.

Chapman et al., 2006, Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain., Neurotoxicology

Friedland et al., 1993, Comparison of endotoxin release by different antimicrobial agents and the effect on inflammation in experimental Escherichia coli meningitis., J. Infect. Dis.

HingoraniCasas: ENSG00000232810
- Version: 31-May-2017
Alternate Names:

ENSG00000232810 Gene Symbol

TNF Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
TALC: TNF
- Version: 12-May-2016
Alternate Names:

TNF Gene Symbol

Gene Info:

Publications:
ChemblInteractions: TNFA
- Version: chembl_23
Alternate Names:

TNFSF2 GENE_SYMBOL

TNF GENE_SYMBOL

Tumor necrosis factor UNIPROT

Gene Info:

Publications:
GO: TNF
- Version: 01-February-2022
Alternate Names:

TNFA GO Gene Synonym

TNFSF2 GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:
Tempus: TNF
- Version: 11-November-2018
Alternate Names:

TNF Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
ClearityFoundationClinicalTrial: TNF
- Version: 15-June-2013
Alternate Names:

Gene Info:

Publications:
DTC: TNF
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	TNF-alpha inhibitor

Trial Name	ART621, PN0621
Novel drug target	Established target
Mechanism of Interaction	TNF-alpha inhibitor

Mechanism of Interaction	TNF-alpha inhibitor
Direct Interaction	yes
Trial Name	ozoralizumab

Trial Name	infliximab ,Remicade
Novel drug target	Established target
Direct Interaction	yes

Trial Name	dersalazine sodium
Novel drug target	Established target

P01375	Uniprot Accession
ENSG00000204490; ENSG00000206439; ENSG00000228321; ENSG00000228849; ENSG00000230108; ENSG00000223952; ENSG00000232810	Ensembl Gene Id
TNF	Gene Symbol

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

antibody (inhibitory)
inhibitor (inhibitory)

TNF Gene Record

TNF 7124 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction TNF-alpha inhibitor

PMIDs: 21079302

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name ART621, PN0621 Novel drug target Established target Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction TNF-alpha inhibitor Direct Interaction yes Trial Name ozoralizumab

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8354907

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction TNF-alpha inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: 10829362

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name infliximab ,Remicade Novel drug target Established target Direct Interaction yes

PMIDs: 17642244 15674127 15481318 15691299 16052578 16622728 12110154 15804598 15691217 11752352 16456024 26244882 25311255 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17673491 17343250 16909270 16720636 15695296 12847678 12190096

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction TNF-alpha inhibitor Direct Interaction yes Trial Name Humira

PMIDs: 26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096 15046527 15022409 15200343 14532145 11752352 12044041

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor Trial Name Enbrel

PMIDs: 10206649 10405518 10338381 10375846 11752352 10357816 26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096

Sources: TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11855751

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction TNF-alpha inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
21079302

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name ART621, PN0621

Novel drug target Established target

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

Trial Name ozoralizumab

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
8354907

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
10829362

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name infliximab ,Remicade

Novel drug target Established target

Direct Interaction yes

PMIDs:
17642244 15674127 15481318 15691299 16052578 16622728 12110154 15804598 15691217 11752352 16456024 26244882 25311255 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17673491 17343250 16909270 16720636 15695296 12847678 12190096

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction TNF-alpha inhibitor

Direct Interaction yes

Trial Name Humira

PMIDs:
26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096 15046527 15022409 15200343 14532145 11752352 12044041

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

Trial Name Enbrel

PMIDs:
10206649 10405518 10338381 10375846 11752352 10357816 26244882 24192118 23057546 22960943 22760475 22129793 19365401 18713756 18438841 18050183 17343250 16909270 16720636 12847678 12190096

Sources:
TdgClinicalTrial ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
11855751

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction TNF-alpha inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16277693

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name PF-04236921

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
22151084

Sources:
PharmGKB