DGIdb - TLR9 Gene Record

TLR9 54106 Druggable Genome

Alternate Names:

54106
TOLL LIKE RECEPTOR 9
TLR9
CD289
605474
15633
ENSG00000239732
OTTHUMG00000158106
Q9NR96
Toll-like receptor 9
CD_antigen=CD289
ENSG00000173366

AC097637.1
PA38010
T11451

Gene Info:

Target Subclass	TOLL
Target Class	Receptors
Target Subclass	Receptors
Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother
Merrell et al., 2006, Toll-like receptor 9 agonists promote cellular invasion by increasing matrix metalloproteinase activity., Mol. Cancer Res.
Rutz et al., 2004, Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner., Eur. J. Immunol.
Lenert, 2005, Inhibitory oligodeoxynucleotides - therapeutic promise for systemic autoimmune diseases?, Clin. Exp. Immunol.
Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
Huang et al., 2005, Th1-like cytokine induction by heat-killed Brucella abortus is dependent on triggering of TLR9., J. Immunol.
Sun et al., 2007, TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders., Inflamm Allergy Drug Targets

AGATOLIMOD TLR9

Interaction Score: 7.73

Interaction Types & Directionality:

agonist (activating)

inhibitor (inhibitory)

Interaction Info:

Trial Name PF-3512676 , CpG 7909,Promune

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial
LEFITOLIMOD TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TILSOTOLIMOD TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
AGATOLIMOD SODIUM TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Toll-like receptor 9 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
GNKG-168 TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
EMD-1201081 TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
LITENIMOD TLR9

Interaction Score: 3.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
CHLOROQUINE TLR9

Interaction Score: 2.46

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19949061 16849519 15307186 15762869 14579285 16148144

Sources:
DTC
HYDROXYCHLOROQUINE SULFATE TLR9

Interaction Score: 1.93

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Toll-like receptor 9 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
HYDROXYCHLOROQUINE TLR9

Interaction Score: 1.05

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AHCQ, aersolized hydroxychloroquine

Novel drug target Established target

PMIDs:
18220957 14579285

Sources:
TdgClinicalTrial
CHEMBL1520346 TLR9

Interaction Score: 0.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DEMETHOXYCURCUMIN TLR9

Interaction Score: 0.64

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALEXIDINE HYDROCHLORIDE TLR9

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
THIMEROSAL TLR9

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL505670 TLR9

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL429095 TLR9

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

Ensembl: ENSG00000173366
- Version: 101_38
Alternate Names:

AC097637.1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
Ensembl: ENSG00000239732
- Version: 101_38
Alternate Names:

TLR9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q9NR96
- Version: January-2014
Alternate Names:

TLR9 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TOLL

Publications:

PharmGKB: TLR9

Version: 18-August-2020

Alternate Names:

PA38010 PharmGKB ID

Gene Info:

Publications:

Bank S et al., 2014, Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease., Pharmacogenomics J

Loft ND et al., 2018, Associations between functional polymorphisms and response to biological treatment in Danish patients with psoriasis., Pharmacogenomics J

TTD: Toll-like receptor 9

Version: 2020.06.01

Alternate Names:

TLR9 TTD Gene Abbreviation

T11451 TTD Target ID

Gene Info:

Publications:

Lay M et al., 2009, Cationic lipid/DNA complexes (JVRS-100) combined with influenza vaccine (Fluzone) increases antibody response, cellular immunity, and antigenically drifted protection., Vaccine

Friedberg JW et al., 2009, Phase II study of a TLR-9 agonist (1018 ISS) with rituximab in patients with relapsed or refractory follicular lymphoma., Br J Haematol

Galluzzi L et al., 2012, Trial Watch: Experimental Toll-like receptor agonists for cancer therapy., Oncoimmunology

DTC: TLR9
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother
TALC: TLR9
- Version: 12-May-2016
Alternate Names:

TLR9 Gene Symbol

Gene Info:

Publications:
HingoraniCasas: ENSG00000239732
- Version: 31-May-2017
Alternate Names:

ENSG00000239732 Gene Symbol

TLR9 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TLR9
- Version: chembl_23
Alternate Names:

TLR9 GENE_SYMBOL

Toll-like receptor 9 UNIPROT

CD_antigen=CD289 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000173366
- Version: 31-May-2017
Alternate Names:

ENSG00000173366 Gene Symbol

Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

Trial Name	PF-3512676 , CpG 7909,Promune
Novel drug target	Established target
Notes

Mechanism of Interaction	Toll-like receptor 9 agonist
Direct Interaction	yes

Direct Interaction	yes
Mechanism of Interaction	Toll-like receptor 9 antagonist

Trial Name	AHCQ, aersolized hydroxychloroquine
Novel drug target	Established target

TLR9	GENE_SYMBOL
Toll-like receptor 9	UNIPROT
CD_antigen=CD289	UNIPROT

agonist (activating)
inhibitor (inhibitory)

TLR9 Gene Record

TLR9 54106 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: agonist (activating) inhibitor (inhibitory)

Interaction Info: Trial Name PF-3512676 , CpG 7909,Promune Novel drug target Established target Notes

PMIDs: None found

Sources: TALC TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Toll-like receptor 9 agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19949061 16849519 15307186 15762869 14579285 16148144

Sources: DTC

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Toll-like receptor 9 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name AHCQ, aersolized hydroxychloroquine Novel drug target Established target

PMIDs: 18220957 14579285

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Ensembl: ENSG00000173366

Alternate Names: AC097637.1 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

Ensembl: ENSG00000239732

Alternate Names: TLR9 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q9NR96

Alternate Names: TLR9 Gene Symbol

Interaction Types & Directionality:

agonist (activating)

inhibitor (inhibitory)

Interaction Info:

Trial Name PF-3512676 , CpG 7909,Promune

Novel drug target Established target

Notes

PMIDs:
None found

Sources:
TALC TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Toll-like receptor 9 agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19949061 16849519 15307186 15762869 14579285 16148144

Sources:
DTC

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Toll-like receptor 9 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name AHCQ, aersolized hydroxychloroquine

Novel drug target Established target

PMIDs:
18220957 14579285

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

AC097637.1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TLR9 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TLR9 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TOLL

Alternate Names:

PA38010 PharmGKB ID

Alternate Names:

TLR9 TTD Gene Abbreviation

T11451 TTD Target ID

Publications:

Martinson JA et al., 2010, Chloroquine modulates HIV-1-induced plasmacytoid dendritic cell alpha interferon: implication for T-cell activation., Antimicrob Agents Chemother

Alternate Names:

TLR9 Gene Symbol

Alternate Names:

ENSG00000239732 Gene Symbol

TLR9 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TLR9 GENE_SYMBOL

Toll-like receptor 9 UNIPROT

CD_antigen=CD289 UNIPROT

Alternate Names:

ENSG00000173366 Gene Symbol

Ensembl Id

Gene Categories:

DRUGGABLE GENOME