DGIdb - TLR4 Gene Record

TLR4 7099 Druggable Genome

Alternate Names:

7099
TOLL LIKE RECEPTOR 4
TLR4
ARMD10
CD284
TLR-4
TOLL
603030
11850
ENSG00000136869
OTTHUMG00000021046
O00206
hToll
CD_antigen=CD284
Toll-like receptor 4
PA36552
T81443

Gene Info:

Target Class	Receptors
Target Subclass	Receptors
Target Subclass	TOLL
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

CELL SURFACE
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Shimamoto et al., 2006, Inhibition of Toll-like receptor 4 with eritoran attenuates myocardial ischemia-reperfusion injury., Circulation
Kim et al., 2007, Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran., Cell
Boekholdt SM et al., 2003, Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events., Circulation
Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.
Netea et al., 2003, Salmonella septicemia in rheumatoid arthritis patients receiving anti-tumor necrosis factor therapy: association with decreased interferon-gamma production and Toll-like receptor 4 expression., Arthritis Rheum.
Kooloos WM et al., 2010, Functional polymorphisms and methotrexate treatment outcome in recent-onset rheumatoid arthritis., Pharmacogenomics
Uesugi et al., 2001, Toll-like receptor 4 is involved in the mechanism of early alcohol-induced liver injury in mice., Hepatology
Wang Z et al., 2014, Influence of TLR4 rs1927907 locus polymorphisms on tacrolimus pharmacokinetics in the early stage after liver transplantation., Eur J Clin Pharmacol

ERITORAN TLR4

Interaction Score: 22.48

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name eritoran tetrasodium, E5564

Novel drug target Novel Target

PMIDs:
16820585 17803912

Sources:
TdgClinicalTrial TTD
RESATORVID TLR4

Interaction Score: 11.24

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name TAK-242

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD
ERITORAN TETRASODIUM TLR4

Interaction Score: 2.81

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Toll-like receptor 4/MD-2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions
NELFINAVIR TLR4

Interaction Score: 1.61

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
SAQUINAVIR TLR4

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
RITONAVIR TLR4

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15388451

Sources:
NCI
INFLIXIMAB TLR4

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12847679

Sources:
NCI
TACROLIMUS TLR4

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24820765

Sources:
PharmGKB
PRAVASTATIN TLR4

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12742999

Sources:
PharmGKB
ALCOHOL TLR4

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11431739

Sources:
NCI
METHOTREXATE TLR4

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20136356

Sources:
PharmGKB

Ensembl: ENSG00000136869
- Version: 101_38
Alternate Names:

TLR4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: O00206
- Version: January-2014
Alternate Names:

TLR4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TOLL

Publications:

PharmGKB: TLR4

Version: 18-August-2020

Alternate Names:

PA36552 PharmGKB ID

Gene Info:

Publications:

Bank S et al., 2014, Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease., Pharmacogenomics J

Gröndahl-Yli-Hannuksela K et al., 2012, Gene polymorphism in toll-like receptor 4: effect on antibody production and persistence after acellular pertussis vaccination during adolescence., J Infect Dis

Banus S et al., 2007, Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study., Clin Vaccine Immunol

TTD: Toll-like receptor 4
- Version: 2020.06.01
Alternate Names:

TLR4 TTD Gene Abbreviation

T81443 TTD Target ID

Gene Info:

Publications:

Galluzzi L et al., 2012, Trial Watch: Experimental Toll-like receptor agonists for cancer therapy., Oncoimmunology

NCI: TLR4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Equils et al., 2004, Human immunodeficiency virus type 1 protease inhibitors block toll-like receptor 2 (TLR2)- and TLR4-Induced NF-kappaB activation., Antimicrob. Agents Chemother.

Evans et al., 2003, Enhancement of antigen-specific immunity via the TLR4 ligands MPL adjuvant and Ribi.529., Expert Rev Vaccines

Chen et al., 2005, [Heat-shock protein 70 may be a putative endogenous ligand of Toll-like receptor-4 of human monocytes]., Zhonghua Yi Xue Za Zhi

HingoraniCasas: ENSG00000136869
- Version: 31-May-2017
Alternate Names:

ENSG00000136869 Gene Symbol

TLR4 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
ChemblInteractions: TLR4
- Version: chembl_23
Alternate Names:

TLR4 GENE_SYMBOL

Toll-like receptor 4 UNIPROT

hToll UNIPROT

Gene Info:

Publications:
GO: TLR4
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

Publications:

Trial Name	eritoran tetrasodium, E5564
Novel drug target	Novel Target

Direct Interaction	yes
Mechanism of Interaction	Toll-like receptor 4/MD-2 antagonist

TLR4 Gene Record

TLR4 7099 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Trial Name eritoran tetrasodium, E5564 Novel drug target Novel Target

PMIDs: 16820585 17803912

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name TAK-242 Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial TTD

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Toll-like receptor 4/MD-2 antagonist

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15388451

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12847679

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24820765

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12742999

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11431739

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20136356

Sources: PharmGKB

Ensembl: ENSG00000136869

Alternate Names: TLR4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: O00206

Alternate Names: TLR4 Gene Symbol

Gene Info: Target Class Receptors Target Subclass Receptors Target Subclass TOLL

Publications:

PharmGKB: TLR4

Alternate Names: PA36552 PharmGKB ID

Gene Info:

TTD: Toll-like receptor 4

Alternate Names: TLR4 TTD Gene Abbreviation T81443 TTD Target ID

Gene Info:

Publications: Galluzzi L et al., 2012, Trial Watch: Experimental Toll-like receptor agonists for cancer therapy., Oncoimmunology

NCI: TLR4

Alternate Names:

Gene Info:

HingoraniCasas: ENSG00000136869

Alternate Names: ENSG00000136869 Gene Symbol TLR4 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

ChemblInteractions: TLR4

Alternate Names: TLR4 GENE_SYMBOL Toll-like receptor 4 UNIPROT hToll UNIPROT

Gene Info:

Publications:

GO: TLR4

Alternate Names:

Gene Info:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name eritoran tetrasodium, E5564

Novel drug target Novel Target

PMIDs:
16820585 17803912

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name TAK-242

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial TTD

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Toll-like receptor 4/MD-2 antagonist

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15388451

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12847679

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
24820765

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
12742999

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11431739

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20136356

Sources:
PharmGKB

Alternate Names:

TLR4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TLR4 Gene Symbol

Gene Info:

Target Class Receptors

Target Subclass Receptors

Target Subclass TOLL

Alternate Names:

PA36552 PharmGKB ID

Alternate Names:

TLR4 TTD Gene Abbreviation

T81443 TTD Target ID

Publications:

Galluzzi L et al., 2012, Trial Watch: Experimental Toll-like receptor agonists for cancer therapy., Oncoimmunology

Alternate Names:

ENSG00000136869 Gene Symbol

TLR4 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TLR4 GENE_SYMBOL

Toll-like receptor 4 UNIPROT

hToll UNIPROT

Gene Categories:

CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE