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THBS1 Gene Record

  • Summary
  • Interactions
  • Claims
  • THBS1 7057 Druggable Genome

    Alternate Names:

    7057
    THROMBOSPONDIN 1
    THBS1
    THBS
    THBS-1
    TSP
    TSP-1
    TSP1
    188060
    11785
    ENSG00000137801
    OTTHUMG00000133665
    Thrombospondin-1
    T30784
    P07996

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Chen et al., 1997, Thrombospondin, a negative modulator of megakaryocytopoiesis., J. Lab. Clin. Med.
    Riessen et al., 1999, Effect of HMG-CoA reductase inhibitors on extracellular matrix expression in human vascular smooth muscle cells., Basic Res. Cardiol.
    Truter et al., Vesnarinone-mediated alterations of gene expression in cardiac fibroblasts from aortic regurgitant hearts., Am J Ther
    Lafeuillade et al., 1996, Opposite regulation of thrombospondin-1 and corticotropin-induced secreted protein/thrombospondin-2 expression by adrenocorticotropic hormone in adrenocortical cells., J. Cell. Physiol.
    Wang et al., 2006, [Effects of pioglitazone on MKP-1 and TSP-1 expression in early stages of diabetic retinopathy induced by streptozotocin]., Zhejiang Da Xue Xue Bao Yi Xue Ban
    Rath et al., 2006, The C-terminal CD47/IAP-binding domain of thrombospondin-1 prevents camptothecin- and doxorubicin-induced apoptosis in human thyroid carcinoma cells., Biochim. Biophys. Acta
  • METHYLCELLULOSE   THBS1

    Interaction Score: 7.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9016860


    Sources:
    NCI

  • VESNARINONE   THBS1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15356428


    Sources:
    NCI

  • ABT-510   THBS1

    Interaction Score: 1.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • CORTICOTROPIN   THBS1

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8698834


    Sources:
    NCI

  • PIOGLITAZONE   THBS1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17063547


    Sources:
    NCI

  • CAMPTOTHECIN   THBS1

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16962673


    Sources:
    NCI

  • LOVASTATIN   THBS1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10543307


    Sources:
    NCI

  • SIMVASTATIN   THBS1

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10543307


    Sources:
    NCI

  • Ensembl: ENSG00000137801

    • Version: 101_38

    Alternate Names:
    THBS1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: THBS1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Crombie et al., 1998, Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva., J. Exp. Med.
    Chua et al., 1997, Regulation of thrombospondin-1 production by angiotensin II in rat heart endothelial cells., Biochim. Biophys. Acta
    Yano et al., 2004, Ultraviolet B-induced skin angiogenesis is associated with a switch in the balance of vascular endothelial growth factor and thrombospondin-1 expression., J. Invest. Dermatol.

  • HingoraniCasas: ENSG00000137801

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137801 Gene Symbol
    THBS1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TALC: THBS1

    • Version: 12-May-2016

    Alternate Names:
    THBS1 Gene Symbol

    Gene Info:

    Publications:

  • GO: THBS1

    • Version: 01-February-2022

    Alternate Names:
    TSP GO Gene Synonym
    TSP1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

  • TTD: Thrombospondin-1

    • Version: 2020.06.01

    Alternate Names:
    THBS1 TTD Gene Abbreviation
    T30784 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: THBS1

    • Version: 01-February-2022

    Alternate Names:
    Thrombospondin-1 Gene Name
    P07996 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21