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TGFB1 Gene Record

  • Summary
  • Interactions
  • Claims
  • TGFB1 7040 Druggable Genome

    Alternate Names:

    7040
    TRANSFORMING GROWTH FACTOR BETA 1
    TGFB1
    CED
    DPD1
    LAP
    TGFB
    TGFbeta
    190180
    11766
    ENSG00000105329
    OTTHUMG00000182760
    TGF-beta-1
    Transforming growth factor beta-1
    Latency-associated peptide
    PA350
    T97257
    Transforming growth factor beta
    T06011
    IBDIMDE
    TGF-beta1
    P01137
    Transforming growth factor beta-1 proprotein

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    GROWTH FACTOR
    DRUGGABLE GENOME
    TRANSCRIPTION FACTOR

    Publications:

    Hong et al., 2002, Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells., Chemotherapy
    Bhattacharyya et al., 1994, Protooncogene, growth factor, growth factor receptor, and estrogen and progesterone receptor gene expression in the immature rat uterus after treatment with estrogen and tamoxifen., J. Submicrosc. Cytol. Pathol.
    Lindor et al., 2003, Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone., Am. J. Gastroenterol.
    Carroll et al., 2002, Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts., Dermatol Surg
    Lebrethon et al., 1994, Regulation of corticotropin and steroidogenic enzyme mRNAs in human fetal adrenal cells by corticotropin, angiotensin-II and transforming growth factor beta 1., Mol. Cell. Endocrinol.
    Langlois et al., 1994, Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells., Endocrinology
    He et al., 2004, Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases., Toxicol. Sci.
    Li J et al., 2016, A novel genetic score model of UGT1A1 and TGFB pathway as predictor of severe irinotecan-related diarrhea in metastatic colorectal cancer patients., J Cancer Res Clin Oncol
    Qi et al., 2001, [Antifibrotic effects of genistein and quercetin in vitro]., Yao Xue Xue Bao
    Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine
    Gong et al., 2002, Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats., Pancreas
    Scaglione et al., 2005, Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial., J. Hypertens.
    Giunti et al., 2008, Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells., Diabetologia
    Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther
    Robinson et al., 1997, Effects of a new 5 alpha reductase inhibitor (epristeride) on human prostate cell cultures., Prostate
    Koutsilieris et al., 1999, Chemotherapy cytotoxicity of human MCF-7 and MDA-MB 231 breast cancer cells is altered by osteoblast-derived growth factors., Mol. Med.
    Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
    Ciftci et al., 2003, Growth factors and chemotherapeutic modulation of breast cancer cells., J. Pharm. Pharmacol.
    Gora-Tybor et al., 2002, Cladribine decreases the level of angiogenic factors in patients with chronic lymphocytic leukemia., Neoplasma
    Hallberg et al., 2004, Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol
    Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.
    Wang et al., 2005, Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage., Stem Cells
    Cucina et al., 1999, Nicotine regulates basic fibroblastic growth factor and transforming growth factor beta1 production in endothelial cells., Biochem. Biophys. Res. Commun.
    Yung et al., 2001, Emodin ameliorates glucose-induced morphologic abnormalities and synthesis of transforming growth factor beta1 and fibronectin by human peritoneal mesothelial cells., Perit Dial Int
    Neuzillet C et al., 2014, Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas., Oncotarget
    Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.
    Roberson et al., 1997, Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells., Cell Growth Differ.
    Jia et al., 2007, [Effects of pioglitazone on the morphology and the expression of connective tissue growth factor of transforming growth factor beta-induced rat hepatic stellate cells in vitro]., Zhonghua Gan Zang Bing Za Zhi
    Jiang et al., The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway., Anticancer Res.
  • DISITERTIDE   TGFB1

    Interaction Score: 3.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24393789


    Sources:
    TTD

  • SANDOSTATIN   TGFB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12142738


    Sources:
    NCI

  • NIS-793   TGFB1

    Interaction Score: 1.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FRESOLIMUMAB   TGFB1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    antibody (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Transforming growth factor beta-1 inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TALC ChemblInteractions

  • SILYBIN A   TGFB1

    Interaction Score: 1.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15103051


    Sources:
    NCI

  • LY-2382770   TGFB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Transforming growth factor beta-1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • METELIMUMAB   TGFB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Transforming growth factor beta-1 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • RAMIPRIL   TGFB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15716710


    Sources:
    NCI

  • VACTOSERTIB   TGFB1

    Interaction Score: 0.84

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • PIRFENIDONE   TGFB1

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12907346


    Sources:
    NCI TTD

  • AMIFOSTINE   TGFB1

    Interaction Score: 0.67

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12005544


    Sources:
    NCI

  • SOTATERCEPT   TGFB1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • M-7824   TGFB1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • TOREMIFENE   TGFB1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12476040


    Sources:
    NCI

  • VITAMIN E   TGFB1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9608545


    Sources:
    NCI

  • RITUXIMAB   TGFB1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22129793


    Sources:
    PharmGKB

  • INOSITOL   TGFB1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8013389


    Sources:
    NCI

  • PIOGLITAZONE   TGFB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17407709


    Sources:
    NCI

  • CLADRIBINE   TGFB1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12097998


    Sources:
    NCI

  • ADRIAMYCIN   TGFB1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10203574


    Sources:
    NCI

  • TRIAMCINOLONE   TGFB1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12174062


    Sources:
    NCI

  • FENRETINIDE   TGFB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8993839


    Sources:
    NCI

  • EMODIN   TGFB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11887862


    Sources:
    NCI

  • MELATONIN   TGFB1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9649124


    Sources:
    NCI

  • ATENOLOL   TGFB1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15049387


    Sources:
    NCI

  • TESTOSTERONE   TGFB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9288184


    Sources:
    NCI

  • HYDROCORTISONE   TGFB1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7895901


    Sources:
    NCI

  • STREPTOZOCIN   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17968528


    Sources:
    NCI

  • GOSSYPOL   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15015581


    Sources:
    NCI

  • NICOTINE   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10198208


    Sources:
    NCI

  • GENISTEIN   TGFB1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12580099


    Sources:
    NCI

  • ETOPOSIDE   TGFB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16002781


    Sources:
    NCI

  • IRINOTECAN   TGFB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27160286


    Sources:
    PharmGKB

  • TAMOXIFEN   TGFB1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8019941


    Sources:
    NCI

  • VERAPAMIL   TGFB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    NCI

  • ASPIRIN   TGFB1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19138248


    Sources:
    PharmGKB

  • DOXORUBICIN   TGFB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12956904


    Sources:
    NCI

  • Ensembl: ENSG00000105329

    • Version: 101_38

    Alternate Names:
    TGFB1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: TGFB1

    • Version: 18-August-2020

    Alternate Names:
    PA350 PharmGKB ID

    Gene Info:

    Publications:
    Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine
    Li J et al., 2016, A novel genetic score model of UGT1A1 and TGFB pathway as predictor of severe irinotecan-related diarrhea in metastatic colorectal cancer patients., J Cancer Res Clin Oncol
    Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther

  • TTD: Transforming growth factor beta 1

    • Version: 2020.06.01

    Alternate Names:
    TGFB1 TTD Gene Abbreviation
    T97257 TTD Target ID

    Gene Info:

    Publications:
    Neuzillet C et al., 2014, Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas., Oncotarget

  • NCI: TGFB1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Hong et al., 2002, Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells., Chemotherapy
    He et al., 2004, Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases., Toxicol. Sci.
    Gong et al., 2002, Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats., Pancreas

  • TALC: TGFB1

    • Version: 12-May-2016

    Alternate Names:
    TGFB1 Gene Symbol

    Gene Info:

    Publications:

  • ChemblInteractions: TGFB

    • Version: chembl_23

    Alternate Names:
    TGFB GENE_SYMBOL
    TGFB1 GENE_SYMBOL
    Transforming growth factor beta-1 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000105329

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000105329 Gene Symbol
    TGFB1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: TGFB1

    • Version: 01-February-2022

    Alternate Names:
    TGFB GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE, GROWTH FACTOR

    Publications:

  • TTD: Transforming growth factor beta

    • Version: 2020.06.01

    Alternate Names:
    TGFB TTD Gene Abbreviation
    T06011 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: TGFB1

    • Version: 01-February-2022

    Alternate Names:
    Transforming growth factor beta-1 proprotein Gene Name
    P01137 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21