DGIdb - TGFB1 Gene Record

TGFB1 7040 Druggable Genome

Alternate Names:

7040
TRANSFORMING GROWTH FACTOR BETA 1
TGFB1
CED
DPD1
LAP
TGFB
TGFbeta
190180
11766
ENSG00000105329
OTTHUMG00000182760
TGF-beta-1
Transforming growth factor beta-1
Latency-associated peptide
PA350
T97257
Transforming growth factor beta
T06011
IBDIMDE
TGF-beta1
P01137
Transforming growth factor beta-1 proprotein

Gene Info:

Gene Biotype	PROTEIN_CODING

(6 More Sources)

Gene Categories: Category Details

CELL SURFACE
GROWTH FACTOR
DRUGGABLE GENOME
TRANSCRIPTION FACTOR

Publications:

Hong et al., 2002, Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells., Chemotherapy
Bhattacharyya et al., 1994, Protooncogene, growth factor, growth factor receptor, and estrogen and progesterone receptor gene expression in the immature rat uterus after treatment with estrogen and tamoxifen., J. Submicrosc. Cytol. Pathol.
Lindor et al., 2003, Desmoid tumors in familial adenomatous polyposis: a pilot project evaluating efficacy of treatment with pirfenidone., Am. J. Gastroenterol.
Carroll et al., 2002, Triamcinolone stimulates bFGF production and inhibits TGF-beta1 production by human dermal fibroblasts., Dermatol Surg
Lebrethon et al., 1994, Regulation of corticotropin and steroidogenic enzyme mRNAs in human fetal adrenal cells by corticotropin, angiotensin-II and transforming growth factor beta 1., Mol. Cell. Endocrinol.
Langlois et al., 1994, Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells., Endocrinology
He et al., 2004, Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases., Toxicol. Sci.
Li J et al., 2016, A novel genetic score model of UGT1A1 and TGFB pathway as predictor of severe irinotecan-related diarrhea in metastatic colorectal cancer patients., J Cancer Res Clin Oncol
Qi et al., 2001, [Antifibrotic effects of genistein and quercetin in vitro]., Yao Xue Xue Bao
Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine
Gong et al., 2002, Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats., Pancreas
Scaglione et al., 2005, Transforming growth factor beta1 and additional renoprotective effect of combination ACE inhibitor and angiotensin II receptor blocker in hypertensive subjects with minor renal abnormalities: a 24-week randomized controlled trial., J. Hypertens.
Giunti et al., 2008, Monocyte chemoattractant protein-1 has prosclerotic effects both in a mouse model of experimental diabetes and in vitro in human mesangial cells., Diabetologia
Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther
Robinson et al., 1997, Effects of a new 5 alpha reductase inhibitor (epristeride) on human prostate cell cultures., Prostate
Koutsilieris et al., 1999, Chemotherapy cytotoxicity of human MCF-7 and MDA-MB 231 breast cancer cells is altered by osteoblast-derived growth factors., Mol. Med.
Eck et al., 1998, A sequential treatment regimen with melatonin and all-trans retinoic acid induces apoptosis in MCF-7 tumour cells., Br. J. Cancer
Ciftci et al., 2003, Growth factors and chemotherapeutic modulation of breast cancer cells., J. Pharm. Pharmacol.
Gora-Tybor et al., 2002, Cladribine decreases the level of angiogenic factors in patients with chronic lymphocytic leukemia., Neoplasma
Hallberg et al., 2004, Transforming growth factor beta1 genotype and change in left ventricular mass during antihypertensive treatment--results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation versus Atenolol (SILVHIA)., Clin Cardiol
Vujaskovic et al., 2002, Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity., Radiat. Res.
Wang et al., 2005, Activation of transforming growth factor-beta1/p38/Smad3 signaling in stromal cells requires reactive oxygen species-mediated MMP-2 activity during bone marrow damage., Stem Cells
Cucina et al., 1999, Nicotine regulates basic fibroblastic growth factor and transforming growth factor beta1 production in endothelial cells., Biochem. Biophys. Res. Commun.
Yung et al., 2001, Emodin ameliorates glucose-induced morphologic abnormalities and synthesis of transforming growth factor beta1 and fibronectin by human peritoneal mesothelial cells., Perit Dial Int
Neuzillet C et al., 2014, Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas., Oncotarget
Chan et al., 1998, alpha-Tocopherol reduces proteinuria, oxidative stress, and expression of transforming growth factor beta 1 in IgA nephropathy in the rat., Mol. Genet. Metab.
Roberson et al., 1997, Fenretinide: induction of apoptosis and endogenous transforming growth factor beta in PC-3 prostate cancer cells., Cell Growth Differ.
Jia et al., 2007, [Effects of pioglitazone on the morphology and the expression of connective tissue growth factor of transforming growth factor beta-induced rat hepatic stellate cells in vitro]., Zhonghua Gan Zang Bing Za Zhi
Jiang et al., The inhibitory effects of gossypol on human prostate cancer cells-PC3 are associated with transforming growth factor beta1 (TGFbeta1) signal transduction pathway., Anticancer Res.

DISITERTIDE TGFB1

Interaction Score: 3.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24393789

Sources:
TTD
SANDOSTATIN TGFB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12142738

Sources:
NCI
NIS-793 TGFB1

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FRESOLIMUMAB TGFB1

Interaction Score: 1.11

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions
SILYBIN A TGFB1

Interaction Score: 1.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15103051

Sources:
NCI
LY-2382770 TGFB1

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
METELIMUMAB TGFB1

Interaction Score: 0.84

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
RAMIPRIL TGFB1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15716710

Sources:
NCI
VACTOSERTIB TGFB1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
PIRFENIDONE TGFB1

Interaction Score: 0.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12907346

Sources:
NCI TTD
AMIFOSTINE TGFB1

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12005544

Sources:
NCI
SOTATERCEPT TGFB1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
M-7824 TGFB1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
TOREMIFENE TGFB1

Interaction Score: 0.48

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12476040

Sources:
NCI
VITAMIN E TGFB1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9608545

Sources:
NCI
RITUXIMAB TGFB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22129793

Sources:
PharmGKB
INOSITOL TGFB1

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8013389

Sources:
NCI
PIOGLITAZONE TGFB1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17407709

Sources:
NCI
CLADRIBINE TGFB1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12097998

Sources:
NCI
ADRIAMYCIN TGFB1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10203574

Sources:
NCI
TRIAMCINOLONE TGFB1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12174062

Sources:
NCI
FENRETINIDE TGFB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8993839

Sources:
NCI
EMODIN TGFB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11887862

Sources:
NCI
MELATONIN TGFB1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9649124

Sources:
NCI
ATENOLOL TGFB1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15049387

Sources:
NCI
TESTOSTERONE TGFB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9288184

Sources:
NCI
HYDROCORTISONE TGFB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7895901

Sources:
NCI
STREPTOZOCIN TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17968528

Sources:
NCI
GOSSYPOL TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15015581

Sources:
NCI
NICOTINE TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10198208

Sources:
NCI
GENISTEIN TGFB1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12580099

Sources:
NCI
ETOPOSIDE TGFB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16002781

Sources:
NCI
IRINOTECAN TGFB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27160286

Sources:
PharmGKB
TAMOXIFEN TGFB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8019941

Sources:
NCI
VERAPAMIL TGFB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
NCI
ASPIRIN TGFB1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19138248

Sources:
PharmGKB
DOXORUBICIN TGFB1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12956904

Sources:
NCI

Ensembl: ENSG00000105329
- Version: 101_38
Alternate Names:

TGFB1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: TGFB1

Version: 18-August-2020

Alternate Names:

PA350 PharmGKB ID

Gene Info:

Publications:

Daïen CI et al., 2012, TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis., Joint Bone Spine

Li J et al., 2016, A novel genetic score model of UGT1A1 and TGFB pathway as predictor of severe irinotecan-related diarrhea in metastatic colorectal cancer patients., J Cancer Res Clin Oncol

Park HJ et al., 2008, Association between a TGFbeta1 promoter polymorphism and the phenotype of aspirin-intolerant chronic urticaria in a Korean population., J Clin Pharm Ther

TTD: Transforming growth factor beta 1
- Version: 2020.06.01
Alternate Names:

TGFB1 TTD Gene Abbreviation

T97257 TTD Target ID

Gene Info:

Publications:

Neuzillet C et al., 2014, Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas., Oncotarget

NCI: TGFB1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Hong et al., 2002, Antiproliferative properties of toremifene on AIDS-related Kaposi's sarcoma cells., Chemotherapy

He et al., 2004, Silymarin protects against liver damage in BALB/c mice exposed to fumonisin B1 despite increasing accumulation of free sphingoid bases., Toxicol. Sci.

Gong et al., 2002, Mechanisms of Chinese herb emodin and somatostatin analogs on pancreatic regeneration in acute pancreatitis in rats., Pancreas

TALC: TGFB1
- Version: 12-May-2016
Alternate Names:

TGFB1 Gene Symbol

Gene Info:

Publications:
ChemblInteractions: TGFB
- Version: chembl_23
Alternate Names:

TGFB GENE_SYMBOL

TGFB1 GENE_SYMBOL

Transforming growth factor beta-1 UNIPROT

Gene Info:

Publications:
HingoraniCasas: ENSG00000105329
- Version: 31-May-2017
Alternate Names:

ENSG00000105329 Gene Symbol

TGFB1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: TGFB1
- Version: 01-February-2022
Alternate Names:

TGFB GO Gene Synonym

Gene Info:

Gene Categories:

CELL SURFACE, GROWTH FACTOR

Publications:
TTD: Transforming growth factor beta
- Version: 2020.06.01
Alternate Names:

TGFB TTD Gene Abbreviation

T06011 TTD Target ID

Gene Info:

Publications:
Pharos: TGFB1
- Version: 01-February-2022
Alternate Names:

Transforming growth factor beta-1 proprotein Gene Name

P01137 UniProt ID

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR

Publications:

Mechanism of Interaction	Transforming growth factor beta-1 inhibitor
Direct Interaction	yes
Notes

TGFB	GENE_SYMBOL
TGFB1	GENE_SYMBOL
Transforming growth factor beta-1	UNIPROT

Transforming growth factor beta-1 proprotein	Gene Name
P01137	UniProt ID

antibody (inhibitory)
inhibitor (inhibitory)

TGFB1 Gene Record

TGFB1 7040 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24393789

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12142738

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: antibody (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Transforming growth factor beta-1 inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15103051

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Transforming growth factor beta-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Transforming growth factor beta-1 inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15716710

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12907346

Sources: NCI TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12005544

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12476040

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9608545

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22129793

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8013389

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17407709

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
24393789

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12142738

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

antibody (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15103051

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Transforming growth factor beta-1 inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
15716710

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12907346

Sources:
NCI TTD

Interaction Types & Directionality:

n/a

PMIDs:
12005544

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12476040

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9608545

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
22129793

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8013389

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17407709

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12097998

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10203574

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12174062

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8993839

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11887862

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9649124

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15049387

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9288184