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TG Gene Record

  • Summary
  • Interactions
  • Claims
  • TG 7038 Druggable Genome

    Alternate Names:

    7038
    THYROGLOBULIN
    TG
    AITD3
    TGN
    188450
    11764
    ENSG00000042832
    OTTHUMG00000164649
    THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266]
    THYG_HUMAN
    P01266

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Short Name CarbesteraseB
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name Carboxylesterase, type B
    Interpro Acc IPR002018
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    HORMONE ACTIVITY
    DRUGGABLE GENOME

    Publications:

    Chung et al., 1999, Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan., J. Nucl. Med.
    Ericsson et al., Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid., Epilepsia
    Broussolle et al., 1989, Rapid effectiveness of prednisone and thionamides combined therapy in severe amiodarone iodine-induced thyrotoxicosis. Comparison of two groups of patients with apparently normal thyroid glands., J. Endocrinol. Invest.
    Yamada et al., 1996, Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid., J. Clin. Endocrinol. Metab.
    Yamamoto et al., 1987, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis., Clin. Endocrinol. (Oxf)
    Cappiello et al., 1995, Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis., J. Endocrinol. Invest.
    Avvedimento et al., 1989, Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine., Cell
    Williams et al., 1975, Acute effects of corticosteroids on thyroid activity in Graves' disease., J. Clin. Endocrinol. Metab.
    Dackiw et al., 2004, Vitamin D3 administration induces nuclear p27 accumulation, restores differentiation, and reduces tumor burden in a mouse model of metastatic follicular thyroid cancer., Endocrinology
    Grüning et al., 2003, Retinoic acid for redifferentiation of thyroid cancer--does it hold its promise?, Eur. J. Endocrinol.
    Scalzo et al., 1990, Primary hypothyroidism associated with interleukin-2 and interferon alpha-2 therapy of melanoma and renal carcinoma., Eur. J. Cancer
    Milerová et al., 2006, Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters., Clin. Chem. Lab. Med.
    Aouani et al., 1999, Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by phosphatidylinositol-3-kinase: a study with wortmannin., Arch. Physiol. Biochem.
    Fröhlich et al., 2001, Effects of retinoids on porcine thyrocytes under different culture conditions., Histochem. J.
    Brown et al., Assessment of thyrotoxicity using in vitro cell culture systems., Food Chem. Toxicol.
    Elias et al., 2006, Enhanced radioiodine uptake in a patient with poorly differentiated papillary thyroid cancer after treatment with rosiglitazone., Clin Nucl Med
    Philips et al., 2004, Effect of peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, on dedifferentiated thyroid cancers., Nucl Med Commun
    Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.
    Lupoli et al., 1993, [Treatment of hot thyroid nodule with percutaneous ethanol injection. Our experience]., Minerva Endocrinol.
    Kostoglou-Athanassiou et al., 2003, Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature., Horm. Res.
  • ACEBUTOLOL   TG

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2878948


    Sources:
    NCI

  • HEXAMETHYLENEBISACETAMIDE   TG

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10650339


    Sources:
    NCI

  • FLUDEOXYGLUCOSE-F18   TG

    Interaction Score: 1.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10452315


    Sources:
    NCI

  • AMINOGLUTETHIMIDE   TG

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3781413


    Sources:
    NCI

  • OCTREOTIDE   TG

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14530610


    Sources:
    NCI

  • ISOTRETINOIN   TG

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12656659


    Sources:
    NCI

  • CALCITRIOL   TG

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15319350


    Sources:
    NCI

  • RETINOL   TG

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11563543


    Sources:
    NCI

  • ROSIGLITAZONE   TG

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16921272 15640776


    Sources:
    NCI

  • PREDNISOLONE   TG

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8636270 3427792


    Sources:
    NCI

  • AMIODARONE   TG

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8778159


    Sources:
    NCI

  • ALDESLEUKIN   TG

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2149997


    Sources:
    NCI

  • PREDNISONE   TG

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2745931


    Sources:
    NCI

  • AZACITIDINE   TG

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2476239


    Sources:
    NCI

  • PHENYTOIN   TG

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3935423


    Sources:
    NCI

  • GENISTEIN   TG

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16475902


    Sources:
    NCI

  • DEXAMETHASONE   TG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1174132


    Sources:
    NCI

  • ALCOHOL   TG

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8289752


    Sources:
    NCI

  • Ensembl: ENSG00000042832

    • Version: 101_38

    Alternate Names:
    TG Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • HopkinsGroom: P01266

    • Version: 11-September-2012

    Alternate Names:
    TG Uniprot Gene Name
    ENSG00000042832 Ensembl Gene Id
    THYG_HUMAN Uniprot Id

    Gene Info:
    Interpro Type Domain
    Uniprot Status Swiss-Prot
    Interpro Short Name CarbesteraseB

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • RussLampel: ENSG00000042832

    • Version: 26-July-2011

    Alternate Names:
    TG Display Id
    THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266] Description
    ENSG00000042832 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • NCI: TG

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Ericsson et al., Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid., Epilepsia
    Avvedimento et al., 1989, Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine., Cell
    Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

  • HingoraniCasas: ENSG00000042832

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000042832 Gene Symbol
    TG Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: TG

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    HORMONE ACTIVITY

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21