DGIdb - TG Gene Record

TG 7038 Druggable Genome

Alternate Names:

7038
THYROGLOBULIN
TG
AITD3
TGN
188450
11764
ENSG00000042832
OTTHUMG00000164649
THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266]
THYG_HUMAN
P01266

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Short Name	CarbesteraseB
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Carboxylesterase, type B
Interpro Acc	IPR002018
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

HORMONE ACTIVITY
DRUGGABLE GENOME

Publications:

Chung et al., 1999, Value of FDG PET in papillary thyroid carcinoma with negative 131I whole-body scan., J. Nucl. Med.
Ericsson et al., Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid., Epilepsia
Broussolle et al., 1989, Rapid effectiveness of prednisone and thionamides combined therapy in severe amiodarone iodine-induced thyrotoxicosis. Comparison of two groups of patients with apparently normal thyroid glands., J. Endocrinol. Invest.
Yamada et al., 1996, Dissociation between serum interleukin-6 rise and other parameters of disease activity in subacute thyroiditis during treatment with corticosteroid., J. Clin. Endocrinol. Metab.
Yamamoto et al., 1987, Effect of prednisolone and salicylate on serum thyroglobulin level in patients with subacute thyroiditis., Clin. Endocrinol. (Oxf)
Cappiello et al., 1995, Ultrastructural evidence of thyroid damage in amiodarone-induced thyrotoxicosis., J. Endocrinol. Invest.
Avvedimento et al., 1989, Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine., Cell
Williams et al., 1975, Acute effects of corticosteroids on thyroid activity in Graves' disease., J. Clin. Endocrinol. Metab.
Dackiw et al., 2004, Vitamin D3 administration induces nuclear p27 accumulation, restores differentiation, and reduces tumor burden in a mouse model of metastatic follicular thyroid cancer., Endocrinology
Grüning et al., 2003, Retinoic acid for redifferentiation of thyroid cancer--does it hold its promise?, Eur. J. Endocrinol.
Scalzo et al., 1990, Primary hypothyroidism associated with interleukin-2 and interferon alpha-2 therapy of melanoma and renal carcinoma., Eur. J. Cancer
Milerová et al., 2006, Actual levels of soy phytoestrogens in children correlate with thyroid laboratory parameters., Clin. Chem. Lab. Med.
Aouani et al., 1999, Hexamethylenebisacetamide modulation of thyroglobulin and protein levels in thyroid cells is not mediated by phosphatidylinositol-3-kinase: a study with wortmannin., Arch. Physiol. Biochem.
Fröhlich et al., 2001, Effects of retinoids on porcine thyrocytes under different culture conditions., Histochem. J.
Brown et al., Assessment of thyrotoxicity using in vitro cell culture systems., Food Chem. Toxicol.
Elias et al., 2006, Enhanced radioiodine uptake in a patient with poorly differentiated papillary thyroid cancer after treatment with rosiglitazone., Clin Nucl Med
Philips et al., 2004, Effect of peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, on dedifferentiated thyroid cancers., Nucl Med Commun
Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.
Lupoli et al., 1993, [Treatment of hot thyroid nodule with percutaneous ethanol injection. Our experience]., Minerva Endocrinol.
Kostoglou-Athanassiou et al., 2003, Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature., Horm. Res.

ACEBUTOLOL TG

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2878948

Sources:
NCI
HEXAMETHYLENEBISACETAMIDE TG

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10650339

Sources:
NCI
FLUDEOXYGLUCOSE-F18 TG

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10452315

Sources:
NCI
AMINOGLUTETHIMIDE TG

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3781413

Sources:
NCI
OCTREOTIDE TG

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14530610

Sources:
NCI
ISOTRETINOIN TG

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12656659

Sources:
NCI
CALCITRIOL TG

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15319350

Sources:
NCI
RETINOL TG

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11563543

Sources:
NCI
ROSIGLITAZONE TG

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16921272 15640776

Sources:
NCI
PREDNISOLONE TG

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8636270 3427792

Sources:
NCI
AMIODARONE TG

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8778159

Sources:
NCI
ALDESLEUKIN TG

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2149997

Sources:
NCI
PREDNISONE TG

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2745931

Sources:
NCI
AZACITIDINE TG

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2476239

Sources:
NCI
PHENYTOIN TG

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3935423

Sources:
NCI
GENISTEIN TG

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16475902

Sources:
NCI
DEXAMETHASONE TG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1174132

Sources:
NCI
ALCOHOL TG

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8289752

Sources:
NCI

Ensembl: ENSG00000042832
- Version: 101_38
Alternate Names:

TG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P01266
- Version: 11-September-2012
Alternate Names:

TG Uniprot Gene Name

ENSG00000042832 Ensembl Gene Id

THYG_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000042832
- Version: 26-July-2011
Alternate Names:

TG Display Id

THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266] Description

ENSG00000042832 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

NCI: TG

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Ericsson et al., Thyroglobulin and thyroid hormones in patients on long-term treatment with phenytoin, carbamazepine, and valproic acid., Epilepsia

Avvedimento et al., 1989, Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine., Cell

Perrild et al., 1986, Short-term beta-adrenergic blockade decreases serum thyroglobulin in hyper- and euthyroid patients., J. Endocrinol. Invest.

HingoraniCasas: ENSG00000042832
- Version: 31-May-2017
Alternate Names:

ENSG00000042832 Gene Symbol

TG Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
GO: TG
- Version: 01-February-2022
Alternate Names:

Gene Info:

Gene Categories:

HORMONE ACTIVITY

Publications:

TG	Uniprot Gene Name
ENSG00000042832	Ensembl Gene Id
THYG_HUMAN	Uniprot Id

TG	Display Id
THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266]	Description
ENSG00000042832	Ensembl Gene Id

TG Gene Record

TG 7038 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2878948

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10650339

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10452315

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3781413

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14530610

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12656659

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15319350

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11563543

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16921272 15640776

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8636270 3427792

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8778159

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2149997

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2745931

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2476239

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3935423

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16475902

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1174132

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8289752

Sources: NCI

Ensembl: ENSG00000042832

Alternate Names: TG Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
2878948

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10650339

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10452315

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3781413

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14530610

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12656659

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15319350

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11563543

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16921272 15640776

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8636270 3427792

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8778159

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2149997

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2745931

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2476239

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3935423

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16475902

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1174132

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8289752

Sources:
NCI

Alternate Names:

TG Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

TG Uniprot Gene Name

ENSG00000042832 Ensembl Gene Id

THYG_HUMAN Uniprot Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Short Name CarbesteraseB

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

TG Display Id

THYROGLOBULIN PRECURSOR. [SOURCE:UNIPROT/SWISSPROT;ACC:P01266] Description

ENSG00000042832 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000042832 Gene Symbol

TG Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Gene Categories:

HORMONE ACTIVITY