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TFPI Gene Record

  • Summary
  • Interactions
  • Claims
  • TFPI 7035 Druggable Genome

    Alternate Names:

    7035
    TISSUE FACTOR PATHWAY INHIBITOR
    TFPI
    EPI
    LACI
    TFI
    TFPI1
    152310
    11760
    ENSG00000003436
    OTTHUMG00000132634
    T78890

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    CELL SURFACE
    PROTEASE INHIBITOR
    DRUGGABLE GENOME

    Publications:

    Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.
    Ollivier et al., 2005, Modulation of tissue factor expression by rapamycin and FK-506 in lipopolysaccharide-stimulated human mononuclear cells and serum-stimulated aortic smooth muscle cells., Thromb. Haemost.
    Hansen et al., 2000, Reduction of factor FVIIa activity during heparin therapy. Evidence for assay interactions with tissue factor pathway inhibitor and antithrombin., Thromb. Res.
    Hansen et al., 1995, Effect of cholesterol lowering on intravascular pools of TFPI and its anticoagulant potential in type II hyperlipoproteinemia., Arterioscler. Thromb. Vasc. Biol.
    Dahm et al., 2006, Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1., BMC Cardiovasc Disord
    Bartok et al., 2005, Atorvastatin reduces thrombin generation after percutaneous coronary intervention independent of soluble tissue factor., Thromb. Res.
    Cella et al., 2001, Tissue factor pathway inhibitor release induced by defibrotide and heparins., Clin. Appl. Thromb. Hemost.
    Sebestjen et al., 2004, Statin and fibrate treatment of combined hyperlipidemia: the effects on some novel risk factors., Thromb. Haemost.
  • ARC-19499   TFPI

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DEFIBROTIDE   TFPI

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11441984


    Sources:
    NCI

  • TIFACOGIN   TFPI

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • AZITHROMYCIN   TFPI

    Interaction Score: 1.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16113783


    Sources:
    NCI

  • MUPARFOSTAT   TFPI

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11292191


    Sources:
    NCI

  • FULVESTRANT   TFPI

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17029634


    Sources:
    NCI

  • FENOFIBRATE   TFPI

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15543343


    Sources:
    NCI

  • HEPARIN   TFPI

    Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11150580


    Sources:
    NCI

  • LOVASTATIN   TFPI

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7600119


    Sources:
    NCI

  • ATORVASTATIN   TFPI

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15792677


    Sources:
    NCI

  • Ensembl: ENSG00000003436

    • Version: 101_38

    Alternate Names:
    TFPI Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: TFPI

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Tiemann et al., 1997, Effect of cyclosporine A on the release of tissue factor pathway inhibitor from endothelial cells in heart transplant patients and cell culture., Eur J Clin Chem Clin Biochem
    Demir et al., 2001, Anticoagulant and antiprotease profiles of a novel natural heparinomimetic mannopentaose phosphate sulfate (PI-88)., Clin. Appl. Thromb. Hemost.
    Bartok et al., 2005, Atorvastatin reduces thrombin generation after percutaneous coronary intervention independent of soluble tissue factor., Thromb. Res.

  • HingoraniCasas: ENSG00000003436

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000003436 Gene Symbol
    TFPI Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GO: TFPI

    • Version: 01-February-2022

    Alternate Names:
    LACI GO Gene Synonym
    TFPI1 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • dGene: TFPI

    • Version: 27-Jun-2013

    Alternate Names:
    7035 Gene ID
    EPI dGene Synonym
    LACI dGene Synonym

    Gene Info:

    Gene Categories:
    PROTEASE INHIBITOR

    Publications:

  • TTD: Tissue factor pathway inhibitor

    • Version: 2020.06.01

    Alternate Names:
    TFPI TTD Gene Abbreviation
    T78890 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21