DGIdb - TEC Gene Record

TEC 7006 Druggable GenomeClinically Actionable

Alternate Names:

7006
TEC PROTEIN TYROSINE KINASE
TEC
PSCTK4
600583
11719
ENSG00000135605
OTTHUMG00000128623
P42680
TEC_HUMAN
TYROSINE-PROTEIN KINASE TEC
2238
TYROSINE-PROTEIN KINASE TEC (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P42680]
NP_003206
NM_003215
T15848
BE0009385

Gene Info:

Interpro Short Name	Ser-Thr/Tyr_kinase_cat_dom
Interpro Type	Domain
Interpro Acc	IPR001245
Uniprot Evidence	1: Evidence at protein level
Interpro Name	Serine-threonine/tyrosine-protein kinase catalytic domain
Human Readable Name	KINASE
Human Readable Name	DRUGGABLE GENOME
Uniprot Status	Swiss-Prot
GuideToPharmacology Gene Category Name	Tec family
GuideToPharmacology Gene Category ID	629
Gene Biotype	PROTEIN_CODING

(8 More Sources)

Gene Categories: Category Details

KINASE
TYROSINE KINASE
DRUGGABLE GENOME
CLINICALLY ACTIONABLE
ENZYME

Publications:

Kojima et al., 1997, Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain., Biochem. Biophys. Res. Commun.
Hantschel O et al., 2007, The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib., Proc Natl Acad Sci U S A
Tam CS et al., 2019, Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL., Blood
Guo Y et al., 2019, Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase., J Med Chem
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

ZANUBRUTINIB TEC

Interaction Score: 1.89

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
31340982 31381333

Sources:
DrugBank
INOSITOL TEC

Interaction Score: 1.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9240435

Sources:
NCI
ACALABRUTINIB TEC

Interaction Score: 0.68

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
IBRUTINIB TEC

Interaction Score: 0.41

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DASATINIB TEC

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17684099

Sources:
DTC
FOSTAMATINIB TEC

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000135605
- Version: 101_38
Alternate Names:

TEC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
HopkinsGroom: P42680
- Version: 11-September-2012
Alternate Names:

ENSG00000135605 Ensembl Gene Id

7006 Entrez Gene Id

TYROSINE-PROTEIN KINASE TEC Uniprot Protein Name

Gene Info:

Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

Interpro Type Domain

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
RussLampel: ENSG00000135605
- Version: 26-July-2011
Alternate Names:

TYROSINE-PROTEIN KINASE TEC (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P42680] Description

ENSG00000135605 Ensembl Gene Id

TEC Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:
GuideToPharmacology: 7006
- Version: 29-September-2020
Alternate Names:

11719 HUGO Gene ID

11719 HUGO Gene Symbol

tec protein tyrosine kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Tec family

GuideToPharmacology Gene Category ID 629

Gene Categories:

ENZYME

Publications:

DrugBank: BE0009385

Version: 5.1.7

Alternate Names:

TEC DrugBank Gene Name

P42680 UniProt Accession

7006 Entrez Gene Id

Gene Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

Guo Y et al., 2019, Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase., J Med Chem

Tam CS et al., 2019, Phase 1 study of the selective BTK inhibitor zanubrutinib in B-cell malignancies and safety and efficacy evaluation in CLL., Blood

NCI: TEC
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Kojima et al., 1997, Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain., Biochem. Biophys. Res. Commun.
DTC: TEC
- Version: 02-September-2020
Alternate Names:

Gene Info:

Publications:

Hantschel O et al., 2007, The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib., Proc Natl Acad Sci U S A
HingoraniCasas: ENSG00000135605
- Version: 31-May-2017
Alternate Names:

ENSG00000135605 Gene Symbol

TEC Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: TEC
- Version: 03-September-2020
Alternate Names:

Tyrosine-protein kinase Tec Gene Name

P42680 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
dGene: TEC
- Version: 27-Jun-2013
Alternate Names:

7006 Gene ID

PSCTK4 dGene Synonym

Gene Info:

Gene Categories:

KINASE, TYROSINE KINASE

Publications:
TTD: Tyrosine-protein kinase Tec
- Version: 2020.06.01
Alternate Names:

PSCTK4 TTD Gene Abbreviation

T15848 TTD Target ID

Gene Info:

Publications:
FoundationOneGenes: TEC
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

ENSG00000135605	Ensembl Gene Id
7006	Entrez Gene Id
TYROSINE-PROTEIN KINASE TEC	Uniprot Protein Name

TYROSINE-PROTEIN KINASE TEC (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P42680]	Description
ENSG00000135605	Ensembl Gene Id
TEC	Display Id

11719	HUGO Gene ID
11719	HUGO Gene Symbol
tec protein tyrosine kinase	HUGO Gene Name

TEC	DrugBank Gene Name
P42680	UniProt Accession
7006	Entrez Gene Id

TEC Gene Record

TEC 7006 Druggable GenomeClinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

ZANUBRUTINIB TEC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 31340982 31381333

Sources: DrugBank

INOSITOL TEC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9240435

Sources: NCI

ACALABRUTINIB TEC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

IBRUTINIB TEC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

DASATINIB TEC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17684099

Sources: DTC

FOSTAMATINIB TEC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 26516587

Sources: DrugBank

Ensembl: ENSG00000135605

Alternate Names: TEC Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

HopkinsGroom: P42680

Alternate Names: ENSG00000135605 Ensembl Gene Id 7006 Entrez Gene Id TYROSINE-PROTEIN KINASE TEC Uniprot Protein Name

Gene Info: Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom Interpro Type Domain Interpro Acc IPR001245

Gene Categories: KINASE, DRUGGABLE GENOME

Publications:

RussLampel: ENSG00000135605

Alternate Names: TYROSINE-PROTEIN KINASE TEC (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P42680] Description ENSG00000135605 Ensembl Gene Id TEC Display Id

Gene Info: Human Readable Name DRUGGABLE GENOME

Gene Categories: DRUGGABLE GENOME

Publications:

GuideToPharmacology: 7006

Alternate Names: 11719 HUGO Gene ID 11719 HUGO Gene Symbol tec protein tyrosine kinase HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Tec family GuideToPharmacology Gene Category ID 629

Gene Categories: ENZYME

Publications:

DrugBank: BE0009385

Alternate Names: TEC DrugBank Gene Name P42680 UniProt Accession 7006 Entrez Gene Id

Gene Info:

NCI: TEC

Alternate Names:

Gene Info:

Publications: Kojima et al., 1997, Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain., Biochem. Biophys. Res. Commun.

DTC: TEC

Alternate Names:

Gene Info:

Publications: Hantschel O et al., 2007, The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib., Proc Natl Acad Sci U S A

HingoraniCasas: ENSG00000135605

Alternate Names: ENSG00000135605 Gene Symbol TEC Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

Pharos: TEC

Alternate Names: Tyrosine-protein kinase Tec Gene Name P42680 UniProt ID

Gene Info:

Gene Categories: KINASE

Publications:

dGene: TEC

Alternate Names: 7006 Gene ID PSCTK4 dGene Synonym

Gene Info:

Gene Categories: KINASE, TYROSINE KINASE

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
31340982 31381333

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
9240435

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17684099

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26516587

Sources:
DrugBank

Alternate Names:

TEC Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000135605 Ensembl Gene Id

7006 Entrez Gene Id

TYROSINE-PROTEIN KINASE TEC Uniprot Protein Name

Gene Info:

Interpro Short Name Ser-Thr/Tyr_kinase_cat_dom

Interpro Type Domain

Interpro Acc IPR001245

Gene Categories:

KINASE, DRUGGABLE GENOME

Alternate Names:

TYROSINE-PROTEIN KINASE TEC (EC 2.7.1.112). [SOURCE:UNIPROT/SWISSPROT;ACC:P42680] Description

ENSG00000135605 Ensembl Gene Id

TEC Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

11719 HUGO Gene ID

11719 HUGO Gene Symbol

tec protein tyrosine kinase HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Tec family

GuideToPharmacology Gene Category ID 629

Gene Categories:

ENZYME

Alternate Names:

TEC DrugBank Gene Name

P42680 UniProt Accession

7006 Entrez Gene Id

Publications:

Kojima et al., 1997, Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain., Biochem. Biophys. Res. Commun.

Publications:

Hantschel O et al., 2007, The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib., Proc Natl Acad Sci U S A

Alternate Names:

ENSG00000135605 Gene Symbol

TEC Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Tyrosine-protein kinase Tec Gene Name

P42680 UniProt ID

Gene Categories:

KINASE

Alternate Names:

7006 Gene ID

PSCTK4 dGene Synonym

Gene Categories:

KINASE, TYROSINE KINASE

Alternate Names:

PSCTK4 TTD Gene Abbreviation

T15848 TTD Target ID

Gene Categories:

CLINICALLY ACTIONABLE