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TAC1 Gene Record

  • Summary
  • Interactions
  • Claims
  • TAC1 6863 Druggable Genome

    Alternate Names:

    6863
    TACHYKININ PRECURSOR 1
    TAC1
    Hs.2563
    NK2
    NKNA
    NPK
    TAC2
    162320
    11517
    ENSG00000006128
    OTTHUMG00000154069

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Marvizon et al., 2003, Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord., Br. J. Pharmacol.
    Onogi et al., 1992, Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action., Neuropharmacology
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
    Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.
    Pohl et al., 1987, Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo., Am. J. Physiol.
    Ferner et al., 1991, The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A., Br J Clin Pharmacol
    Hanson et al., 1981, Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems., J. Pharmacol. Exp. Ther.
    Yamamoto et al., 2006, Inhibitory effect of bone resorption and inflammation with etidronate therapy in patients with rheumatoid arthritis for 3 years and in vitro assay in arthritis models., Rheumatol. Int.
    Boisnic et al., 2003, [Contribution of Parodium gel in an experimental model of human gingival inflammation]., Rev Stomatol Chir Maxillofac
    Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.
    Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.
    Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.
    Amano et al., 1998, Inhibition of substance-P-induced histamine release from rat peritoneal mast cells by 8-methoxypsoralen plus long-wave ultraviolet light irradiation: decreased intracellular calcium as a possible mechanism., Int. Arch. Allergy Immunol.
    McCarson et al., 1995, The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration., Neuroscience
    Mózsik et al., 2005, Participation of vanilloid/capsaicin receptors, calcitonin-gene-related peptide and substance P in gastric protection of omeprazole and omeprazole-like compounds., Inflammopharmacology
    Katagiri et al., 2005, Omeprazole raises somatostatin and motilin in human plasma., Biol. Pharm. Bull.
    Crimi et al., 1990, Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P., Ann Allergy
    Amano et al., 1998, Inhibition of substance P-induced histamine release from rat peritoneal mast cells by low doses of protoporphyrin plus long-wave ultraviolet light irradiation: decreased intracellular calcium as a possible mechanism., Clin. Exp. Allergy
    García et al., 1997, Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells., Am. J. Vet. Res.
    Van Neste et al., 1992, Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P., J. Dermatol. Sci.
    Dunzendorfer et al., 1998, Signaling in neuropeptide-induced migration of human eosinophils., J. Leukoc. Biol.
    Valdemarsson et al., 1991, Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors., J. Intern. Med.
    Hwang et al., 1989, Baclofen, gamma-aminobutyric acidB receptors and substance P in the mouse spinal cord., J. Pharmacol. Exp. Ther.
    Kotani et al., 1986, Effects of noxious stimuli and anesthetic agents on substance P content in rat central nervous system., Jpn. J. Pharmacol.
  • NIZATIDINE   TAC1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495560


    Sources:
    NCI

  • GINGER   TAC1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1282221


    Sources:
    NCI

  • MEXILETINE   TAC1

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7686682


    Sources:
    NCI

  • FAMOTIDINE   TAC1

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495560


    Sources:
    NCI

  • ETHER   TAC1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2421032


    Sources:
    NCI

  • NALTREXONE   TAC1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7536308


    Sources:
    NCI

  • METHOXSALEN   TAC1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9430496


    Sources:
    NCI

  • PUROMYCIN   TAC1

    Interaction Score: 0.7

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14623771


    Sources:
    NCI

  • ETIDRONIC ACID   TAC1

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16133581


    Sources:
    NCI

  • BACLOFEN   TAC1

    Interaction Score: 0.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2467977


    Sources:
    NCI

  • LORATADINE   TAC1

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9055977 1283698


    Sources:
    NCI

  • FUROSEMIDE   TAC1

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2048822


    Sources:
    NCI

  • TERFENADINE   TAC1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1696438


    Sources:
    NCI

  • RESERPINE   TAC1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6183051 6174352


    Sources:
    NCI

  • SULINDAC   TAC1

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1707646


    Sources:
    NCI

  • CHLORHEXIDINE   TAC1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14631229


    Sources:
    NCI

  • OMEPRAZOLE   TAC1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16259735 15684503


    Sources:
    NCI

  • PROTOPORPHYRIN   TAC1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9677143


    Sources:
    NCI

  • WORTMANNIN   TAC1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9850167


    Sources:
    NCI

  • DIGOXIN   TAC1

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1717629


    Sources:
    NCI

  • GOSSYPOL   TAC1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2887120


    Sources:
    NCI

  • HALOPERIDOL   TAC1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6166743


    Sources:
    NCI

  • Ensembl: ENSG00000006128

    • Version: 101_38

    Alternate Names:
    TAC1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: TAC1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Marvizon et al., 2003, Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord., Br. J. Pharmacol.
    Onogi et al., 1992, Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action., Neuropharmacology
    Yamamoto et al., 2006, Inhibitory effect of bone resorption and inflammation with etidronate therapy in patients with rheumatoid arthritis for 3 years and in vitro assay in arthritis models., Rheumatol. Int.

  • HingoraniCasas: ENSG00000006128

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000006128 Gene Symbol
    TAC1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21