DGIdb - TAC1 Gene Record

TAC1 6863 Druggable Genome

Alternate Names:

6863
TACHYKININ PRECURSOR 1
TAC1
Hs.2563
NK2
NKNA
NPK
TAC2
162320
11517
ENSG00000006128
OTTHUMG00000154069

Gene Info:

Gene Biotype	PROTEIN_CODING

(0 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME

Publications:

Marvizon et al., 2003, Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord., Br. J. Pharmacol.
Onogi et al., 1992, Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action., Neuropharmacology
Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.
Pohl et al., 1987, Selective inhibition of endothelium-dependent dilation in resistance-sized vessels in vivo., Am. J. Physiol.
Ferner et al., 1991, The effects of enalapril and sulindac on the dermal response to substance P and neurokinin A., Br J Clin Pharmacol
Hanson et al., 1981, Haloperidol-induced reduction of nigral substance P-like immunoreactivity: a probe for the interactions between dopamine and substance P neuronal systems., J. Pharmacol. Exp. Ther.
Yamamoto et al., 2006, Inhibitory effect of bone resorption and inflammation with etidronate therapy in patients with rheumatoid arthritis for 3 years and in vitro assay in arthritis models., Rheumatol. Int.
Boisnic et al., 2003, [Contribution of Parodium gel in an experimental model of human gingival inflammation]., Rev Stomatol Chir Maxillofac
Marsden et al., 1982, Localization and release of 5-hydroxytryptamine thyrotrophin releasing hormone and substance P in rat ventral spinal cord., Comp. Biochem. Physiol. C, Comp. Pharmacol.
Gilbert et al., 1981, The effects of 5-hydroxytryptamine-depleting drugs on peptides in the ventral spinal cord., Eur. J. Pharmacol.
Kamei et al., 1993, Effects of mexiletine on formalin-induced nociceptive responses in mice., Res. Commun. Chem. Pathol. Pharmacol.
Amano et al., 1998, Inhibition of substance-P-induced histamine release from rat peritoneal mast cells by 8-methoxypsoralen plus long-wave ultraviolet light irradiation: decreased intracellular calcium as a possible mechanism., Int. Arch. Allergy Immunol.
McCarson et al., 1995, The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration., Neuroscience
Mózsik et al., 2005, Participation of vanilloid/capsaicin receptors, calcitonin-gene-related peptide and substance P in gastric protection of omeprazole and omeprazole-like compounds., Inflammopharmacology
Katagiri et al., 2005, Omeprazole raises somatostatin and motilin in human plasma., Biol. Pharm. Bull.
Crimi et al., 1990, Influence of antihistamine (astemizole) and anticholinergic drugs (ipratropium bromide) on bronchoconstriction induced by substance P., Ann Allergy
Amano et al., 1998, Inhibition of substance P-induced histamine release from rat peritoneal mast cells by low doses of protoporphyrin plus long-wave ultraviolet light irradiation: decreased intracellular calcium as a possible mechanism., Clin. Exp. Allergy
García et al., 1997, Effect of H1-antihistamines on histamine release from dispersed canine cutaneous mast cells., Am. J. Vet. Res.
Van Neste et al., 1992, Agonist-antagonist interactions in the skin: comparison of effects of loratadine and cetirizine on skin vascular responses to prick tests with histamine and substance P., J. Dermatol. Sci.
Dunzendorfer et al., 1998, Signaling in neuropeptide-induced migration of human eosinophils., J. Leukoc. Biol.
Valdemarsson et al., 1991, Increased plasma level of substance P in patients with severe congestive heart failure treated with ACE inhibitors., J. Intern. Med.
Hwang et al., 1989, Baclofen, gamma-aminobutyric acidB receptors and substance P in the mouse spinal cord., J. Pharmacol. Exp. Ther.
Kotani et al., 1986, Effects of noxious stimuli and anesthetic agents on substance P content in rat central nervous system., Jpn. J. Pharmacol.

NIZATIDINE TAC1

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI
GINGER TAC1

Interaction Score: 2.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1282221

Sources:
NCI
MEXILETINE TAC1

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7686682

Sources:
NCI
FAMOTIDINE TAC1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI
ETHER TAC1

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2421032

Sources:
NCI
NALTREXONE TAC1

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7536308

Sources:
NCI
METHOXSALEN TAC1

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9430496

Sources:
NCI
PUROMYCIN TAC1

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14623771

Sources:
NCI
ETIDRONIC ACID TAC1

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16133581

Sources:
NCI
BACLOFEN TAC1

Interaction Score: 0.56

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2467977

Sources:
NCI
LORATADINE TAC1

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9055977 1283698

Sources:
NCI
FUROSEMIDE TAC1

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2048822

Sources:
NCI
TERFENADINE TAC1

Interaction Score: 0.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1696438

Sources:
NCI
RESERPINE TAC1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6183051 6174352

Sources:
NCI
SULINDAC TAC1

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1707646

Sources:
NCI
CHLORHEXIDINE TAC1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14631229

Sources:
NCI
OMEPRAZOLE TAC1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16259735 15684503

Sources:
NCI
PROTOPORPHYRIN TAC1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9677143

Sources:
NCI
WORTMANNIN TAC1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9850167

Sources:
NCI
DIGOXIN TAC1

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1717629

Sources:
NCI
GOSSYPOL TAC1

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2887120

Sources:
NCI
HALOPERIDOL TAC1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6166743

Sources:
NCI

Ensembl: ENSG00000006128
- Version: 101_38
Alternate Names:

TAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

NCI: TAC1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Marvizon et al., 2003, Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord., Br. J. Pharmacol.

Onogi et al., 1992, Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: a possible mechanism of its analgesic action., Neuropharmacology

Yamamoto et al., 2006, Inhibitory effect of bone resorption and inflammation with etidronate therapy in patients with rheumatoid arthritis for 3 years and in vitro assay in arthritis models., Rheumatol. Int.

HingoraniCasas: ENSG00000006128
- Version: 31-May-2017
Alternate Names:

ENSG00000006128 Gene Symbol

TAC1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:

TAC1 Gene Record

TAC1 6863 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1282221

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7686682

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2421032

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7536308

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9430496

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14623771

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16133581

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2467977

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9055977 1283698

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2048822

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1696438

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6183051 6174352

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1707646

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14631229

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16259735 15684503

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9677143

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1282221

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7686682

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2421032

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7536308

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9430496

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14623771

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16133581

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2467977

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9055977 1283698

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2048822

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1696438

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6183051 6174352

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1707646

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14631229

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16259735 15684503

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9677143

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9850167

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1717629

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2887120

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6166743

Sources:
NCI

Alternate Names:

TAC1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

ENSG00000006128 Gene Symbol

TAC1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME