DGIdb - STK3 Gene Record

STK3 6788 Druggable Genome

Alternate Names:

6788
SERINE/THREONINE KINASE 3
STK3
KRS1
MST2
605030
11406
ENSG00000104375
OTTHUMG00000164651
Q13188
STK3_HUMAN
2219
SERINE/THREONINE-PROTEIN KINASE 3 (EC 2.7.1.37) (STE20-LIKE KINASE MST2) (MST-2) (MAMMALIAN STE20-LIKE PROTEIN KINASE 2) (SERINE/THREONINE-PROTEIN KINASE KRS-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13188]
SERINE/THREONINE-PROTEIN KINASE 3 36KDA SUBUNIT
NP_006272
NM_001256312
Serine/threonine-protein kinase 3
BE0009384

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Interpro Type	Domain
Uniprot Status	Swiss-Prot
Interpro Acc	IPR002290
Uniprot Evidence	1: Evidence at protein level
Interpro Short Name	Ser/Thr_dual-sp_kinase_dom
Interpro Name	Serine/threonine- / dual-specificity protein kinase, catalytic domain
Human Readable Name	KINASE
GuideToPharmacology Gene Category Name	MST subfamily
GuideToPharmacology Gene Category ID	545
Gene Biotype	PROTEIN_CODING

(7 More Sources)

Gene Categories: Category Details

KINASE
SERINE THREONINE KINASE
DRUGGABLE GENOME
ENZYME

Publications:

Kusakabe K et al., 2013, Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)., J Med Chem
Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.
Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

CHEMBL2005186 STK3

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
VATALANIB STK3

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEP-11981 STK3

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
LY-2090314 STK3

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LAUROGUADINE STK3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SB-220025 STK3

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CHEMBL541400 STK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW843682X STK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
HESPERADIN STK3

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19035792

Sources:
DTC
CHEMBL379975 STK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
SP-600125 STK3

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23634759

Sources:
DTC
KENPAULLONE STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CEDIRANIB STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ALSTERPAULLONE STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
JNJ-7706621 STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PD-0166285 STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
STAUROSPORINE STK3

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
SOTRASTAURIN STK3

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ENTRECTINIB STK3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GW441756X STK3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
RG-1530 STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DOVITINIB STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CYC-116 STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
TAE-684 STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
PF-00562271 STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ILORASERTIB STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
CENISERTIB STK3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FOSTAMATINIB STK3

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26516587

Sources:
DrugBank

Ensembl: ENSG00000104375
- Version: 101_38
Alternate Names:

STK3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000104375

Version: 26-July-2011

Alternate Names:

ENSG00000104375 Ensembl Gene Id

STK3 Display Id

SERINE/THREONINE-PROTEIN KINASE 3 (EC 2.7.1.37) (STE20-LIKE KINASE MST2) (MST-2) (MAMMALIAN STE20-LIKE PROTEIN KINASE 2) (SERINE/THREONINE-PROTEIN KINASE KRS-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13188] Description

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

HopkinsGroom: Q13188
- Version: 11-September-2012
Alternate Names:

SERINE/THREONINE-PROTEIN KINASE 3 36KDA SUBUNIT Uniprot Protein Name

STK3_HUMAN Uniprot Id

6788 Entrez Gene Id

Gene Info:

Interpro Type Domain

Uniprot Status Swiss-Prot

Interpro Acc IPR002290

Gene Categories:

KINASE, DRUGGABLE GENOME

Publications:
GuideToPharmacology: 6788
- Version: 29-September-2020
Alternate Names:

11406 HUGO Gene ID

11406 HUGO Gene Symbol

serine/threonine kinase 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name MST subfamily

GuideToPharmacology Gene Category ID 545

Gene Categories:

ENZYME

Publications:
DrugBank: BE0009384
- Version: 5.1.7
Alternate Names:

STK3 DrugBank Gene Name

Q13188 UniProt Accession

6788 Entrez Gene Id

Gene Info:

Publications:

Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect

DTC: STK3

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Kusakabe K et al., 2013, Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125)., J Med Chem

Bamborough et al., 2008, Assessment of chemical coverage of kinome space and its implications for kinase drug discovery., J. Med. Chem.

HingoraniCasas: ENSG00000104375
- Version: 31-May-2017
Alternate Names:

ENSG00000104375 Gene Symbol

STK3 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
IDG: STK3
- Version: 15-July-2019
Alternate Names:

STK3 Gene Symbol

Gene Info:

Gene Categories:

KINASE

Publications:
Pharos: STK3
- Version: 03-September-2020
Alternate Names:

Serine/threonine-protein kinase 3 Gene Name

Q13188 UniProt ID

Gene Info:

Gene Categories:

KINASE

Publications:
GO: STK3
- Version: 05-September-2020
Alternate Names:

KRS1 GO Gene Synonym

MST2 GO Gene Synonym

Gene Info:

Gene Categories:

SERINE THREONINE KINASE

Publications:
dGene: STK3
- Version: 27-Jun-2013
Alternate Names:

6788 Gene ID

KRS1 dGene Synonym

MST2 dGene Synonym

Gene Info:

Gene Categories:

KINASE, SERINE THREONINE KINASE

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

ENSG00000104375	Ensembl Gene Id
STK3	Display Id
SERINE/THREONINE-PROTEIN KINASE 3 (EC 2.7.1.37) (STE20-LIKE KINASE MST2) (MST-2) (MAMMALIAN STE20-LIKE PROTEIN KINASE 2) (SERINE/THREONINE-PROTEIN KINASE KRS-1). [SOURCE:UNIPROT/SWISSPROT;ACC:Q13188]	Description

SERINE/THREONINE-PROTEIN KINASE 3 36KDA SUBUNIT	Uniprot Protein Name
STK3_HUMAN	Uniprot Id
6788	Entrez Gene Id

11406	HUGO Gene ID
11406	HUGO Gene Symbol
serine/threonine kinase 3	HUGO Gene Name

STK3	DrugBank Gene Name
Q13188	UniProt Accession
6788	Entrez Gene Id

STK3 Gene Record

STK3 6788 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19035792

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23634759

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19035792

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23634759

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC