• Interaction Score: 5.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20873794


    Sources:
    DTC

  • Interaction Score: 2.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Alteration STK11:.
    Alteration STK11:del
    Drug family Anti-diabetic

    PMIDs:
    26574479


    Sources:
    JAX-CKB CGI

  • Interaction Score: 1.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Preclinical - Cell line xenograft

    PMIDs:
    20371716


    Sources:
    JAX-CKB

  • Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    27821489


    Sources:
    JAX-CKB

  • Interaction Score: 0.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29773717


    Sources:
    CIViC

  • Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type breast cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    25436981


    Sources:
    JAX-CKB

  • Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29773717


    Sources:
    CIViC

  • Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Clinical Status case report
    Pathway activation
    Variant Effect loss-of-function


    Sources:
    JAX-CKB CGI DoCM

  • Interaction Score: 0.32

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type sensitive


    Sources:
    JAX-CKB CIViC

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Preclinical - Cell line xenograft

    PMIDs:
    24634413


    Sources:
    JAX-CKB

  • Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Preclinical - Cell line xenograft

    PMIDs:
    25637314


    Sources:
    JAX-CKB

  • Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29773717


    Sources:
    CIViC

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type sensitive

    PMIDs:
    27821489


    Sources:
    JAX-CKB

  • Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    26574479


    Sources:
    JAX-CKB

  • Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type Advanced Solid Tumor
    Response Type no benefit
    Approval Status Preclinical


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy MK-1775 + Cisplatin
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type predicted – sensitive

    PMIDs:
    28652249


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    21325073


    Sources:
    JAX-CKB

  • Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type endometrial cancer
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    24322983


    Sources:
    JAX-CKB

  • Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type non-small cell lung carcinoma
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    27821489


    Sources:
    JAX-CKB

  • Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Alteration STK11:.;KRAS:.
    Alteration STK11:del;KRAS:.
    Drug family MEK inhibitor;Chemotherapy

    PMIDs:
    22425996


    Sources:
    CGI CIViC

  • Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    20142330


    Sources:
    JAX-CKB

  • Interaction Score: 0.08

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    19035792


    Sources:
    DTC

  • Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Approval Status Preclinical
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture

    PMIDs:
    28652249


    Sources:
    JAX-CKB