DGIdb - STAT4 Gene Record

STAT4 6775 Clinically Actionable

Alternate Names:

6775
SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 4
STAT4
SLEB11
600558
11365
ENSG00000138378
OTTHUMG00000132700
Q14765
PA36185

Gene Info:

Target Class	Miscellaneous
Target Subclass	Miscellaneous
Target Subclass	activator of transcription
Gene Biotype	PROTEIN_CODING

(4 More Sources)

Gene Categories: Category Details

KINASE
CLINICALLY ACTIONABLE
TRANSCRIPTION FACTOR

Publications:

Owaki et al., 2006, IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3., J. Immunol.
Zhang et al., 2001, Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice., Exp. Mol. Pathol.

LISOFYLLINE STAT4

Interaction Score: 10.3

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Lisofylline

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
ALDESLEUKIN STAT4

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16493033 11418001

Sources:
NCI
ETANERCEPT STAT4

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000138378
- Version: 101_38
Alternate Names:

STAT4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
TdgClinicalTrial: Q14765
- Version: January-2014
Alternate Names:

STAT4 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass activator of transcription

Publications:

NCI: STAT4

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Zhang et al., 2001, Dysfunction of Stat4 leads to accelerated incidence of chemical-induced thymic lymphomas in mice., Exp. Mol. Pathol.

Owaki et al., 2006, IL-27 suppresses CD28-mediated [correction of medicated] IL-2 production through suppressor of cytokine signaling 3., J. Immunol.

Shin et al., 2005, STAT4 expression in human T cells is regulated by DNA methylation but not by promoter polymorphism., J. Immunol.

PharmGKB: STAT4
- Version: 18-August-2020
Alternate Names:

PA36185 PharmGKB ID

Gene Info:

Publications:
Tempus: STAT4
- Version: 11-November-2018
Alternate Names:

STAT4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Pharos: STAT4
- Version: 01-February-2022
Alternate Names:

Signal transducer and activator of transcription 4 Gene Name

Q14765 UniProt ID

Gene Info:

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Publications:
FoundationOneGenes: STAT4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: STAT4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

Signal transducer and activator of transcription 4	Gene Name
Q14765	UniProt ID

Trial Name	Lisofylline
Novel drug target	Novel Target

STAT4 Gene Record

STAT4 6775 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

LISOFYLLINE STAT4

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Lisofylline Novel drug target Novel Target

PMIDs: None found

Sources: TdgClinicalTrial

ALDESLEUKIN STAT4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16493033 11418001

Sources: NCI

ETANERCEPT STAT4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000138378

Alternate Names: STAT4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

TdgClinicalTrial: Q14765

Alternate Names: STAT4 Gene Symbol

Gene Info: Target Class Miscellaneous Target Subclass Miscellaneous Target Subclass activator of transcription

Publications:

NCI: STAT4

Alternate Names:

Gene Info:

PharmGKB: STAT4

Alternate Names: PA36185 PharmGKB ID

Gene Info:

Publications:

Tempus: STAT4

Alternate Names: STAT4 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Pharos: STAT4

Alternate Names: Signal transducer and activator of transcription 4 Gene Name Q14765 UniProt ID

Gene Info:

Gene Categories: KINASE, TRANSCRIPTION FACTOR

Publications:

FoundationOneGenes: STAT4

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: STAT4

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Lisofylline

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16493033 11418001

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

STAT4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

STAT4 Gene Symbol

Gene Info:

Target Class Miscellaneous

Target Subclass Miscellaneous

Target Subclass activator of transcription

Alternate Names:

PA36185 PharmGKB ID

Alternate Names:

STAT4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

Signal transducer and activator of transcription 4 Gene Name

Q14765 UniProt ID

Gene Categories:

KINASE, TRANSCRIPTION FACTOR

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE