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SSTR1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SSTR1 6751 Druggable Genome

    Alternate Names:

    6751
    SOMATOSTATIN RECEPTOR 1
    SSTR1
    SRIF-2
    SS-1-R
    SS1-R
    SS1R
    182451
    11330
    ENSG00000139874
    OTTHUMG00000140249
    Somatostatin receptor type 1
    P30872
    SSR1_HUMAN
    SOMATOSTATIN RECEPTOR TYPE 1 (SS1R) (SRIF-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30872]
    T16633

    Gene Info:

    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level
    Interpro Name GPCR, rhodopsin-like, 7TM
    Interpro Acc IPR000276
    Human Readable Name G PROTEIN COUPLED RECEPTOR
    Uniprot Status Swiss-Prot
    Interpro Type Family
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors
    Target Subclass GPCR
    Target Class Receptors
    Gene Biotype PROTEIN_CODING
    (9 More Sources)

    Gene Categories: Category Details

    KINASE
    G PROTEIN COUPLED RECEPTOR
    DRUGGABLE GENOME

    Publications:

    Wang et al., 2005, [Expression of somatostatin receptor reporter gene and its correlation with targeted imaging in vivo for detection of pancreas carcinoma]., Zhonghua Zhong Liu Za Zhi
    Jaquet et al., 2005, BIM-23A760, a chimeric molecule directed towards somatostatin and dopamine receptors, vs universal somatostatin receptors ligands in GH-secreting pituitary adenomas partial responders to octreotide., J. Endocrinol. Invest.
    Ruan et al., 2006, SOM230 inhibits insulin-like growth factor-I action in mammary gland development by pituitary independent mechanism: mediated through somatostatin subtype receptor 3?, Mol. Endocrinol.
    Schmid et al., 2005, Short- and long-term effects of octreotide and SOM230 on GH, IGF-I, ACTH, corticosterone and ghrelin in rats., J. Endocrinol. Invest.
    Matrone et al., 2004, Expression and function of somatostatin receptor subtype 1 in human growth hormone secreting pituitary tumors deriving from patients partially responsive or resistant to long-term treatment with somatostatin analogs., Neuroendocrinology
    John et al., 1996, Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2., Gut
    Zatelli et al., 2007, Pasireotide, a multiple somatostatin receptor subtypes ligand, reduces cell viability in non-functioning pituitary adenomas by inhibiting vascular endothelial growth factor secretion., Endocr. Relat. Cancer
    Bruns et al., 2002, SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile., Eur. J. Endocrinol.
    Erchegyi J et al., 2009, Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues., J Med Chem
    Bruno et al., 1994, Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat., Endocrinology
  • CHEMBL442494   SSTR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    19351180


    Sources:
    DTC

  • PASIREOTIDE   SSTR1

    Interaction Score: 6.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name pasireotide, SOM230
    Novel drug target Established target

    PMIDs:
    17395978 11980628


    Sources:
    TdgClinicalTrial TTD

  • OCTREOTIDE   SSTR1

    Interaction Score: 5.56

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name CAM-2029
    Novel drug target Established target
    Trial Name oral octreotide actetate ,Octreolin

    PMIDs:
    16438887 16625841 16223973 16625842 15103227 8566856


    Sources:
    TdgClinicalTrial NCI TEND

  • LANREOTIDE   SSTR1

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name lanreotide ,Somatuline Autogel, Somatuline Depot
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TEND

  • PASIREOTIDE PAMOATE   SSTR1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Somatostatin receptor 1 agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • VELDOREOTIDE   SSTR1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name DG3173
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • PASIREOTIDE DIASPARTATE   SSTR1

    Interaction Score: 1.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Somatostatin receptor 1 agonist

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CHEMBL452157   SSTR1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • OCTREOTIDE ACETATE   SSTR1

    Interaction Score: 1.24

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Somatostatin receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • STREPTOZOCIN   SSTR1

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7956902


    Sources:
    NCI

  • Ensembl: ENSG00000139874

    • Version: 101_38

    Alternate Names:
    SSTR1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • TEND: P30872

    • Version: 01-August-2011

    Alternate Names:
    SSR1_HUMAN Uniprot Id
    ENSG00000139874 Ensembl Gene Id
    SSTR1 Gene Symbol

    Gene Info:
    Transmembrane Helix Count 7
    Target Subclass Rhodopsin
    Target Main Class Receptors

    Publications:

  • RussLampel: ENSG00000139874

    • Version: 26-July-2011

    Alternate Names:
    SOMATOSTATIN RECEPTOR TYPE 1 (SS1R) (SRIF-2). [SOURCE:UNIPROT/SWISSPROT;ACC:P30872] Description
    ENSG00000139874 Ensembl Gene Id
    SSTR1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P30872

    • Version: January-2014

    Alternate Names:
    SSTR1 Gene Symbol

    Gene Info:
    Target Class Receptors
    Target Subclass GPCR
    Target Subclass Rhodopsin

    Publications:

  • HopkinsGroom: P30872

    • Version: 11-September-2012

    Alternate Names:
    SOMATOSTATIN RECEPTOR TYPE 1 Uniprot Protein Name
    ENSG00000139874 Ensembl Gene Id
    SSR1_HUMAN Uniprot Id

    Gene Info:
    Interpro Short Name 7TM_GPCR_Rhodpsn
    Human Readable Name DRUGGABLE GENOME
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME

    Publications:

  • NCI: SSTR1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Bruno et al., 1994, Pituitary and hypothalamic somatostatin receptor subtype messenger ribonucleic acid expression in the food-deprived and diabetic rat., Endocrinology
    John et al., 1996, Positive somatostatin receptor scintigraphy correlates with the presence of somatostatin receptor subtype 2., Gut

  • DTC: SSTR1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Erchegyi J et al., 2009, Novel, potent, and radio-iodinatable somatostatin receptor 1 (sst1) selective analogues., J Med Chem

  • HingoraniCasas: ENSG00000139874

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000139874 Gene Symbol
    SSTR1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: SSTR1

    • Version: chembl_23

    Alternate Names:
    SSTR1 GENE_SYMBOL
    Somatostatin receptor type 1 UNIPROT
    SRIF-2 UNIPROT

    Gene Info:

    Publications:

  • dGene: SSTR1

    • Version: 27-Jun-2013

    Alternate Names:
    6751 Gene ID
    SRIF-2 dGene Synonym
    SS-1-R dGene Synonym

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

  • TTD: Somatostatin receptor type 1

    • Version: 2020.06.01

    Alternate Names:
    SSTR1 TTD Gene Abbreviation
    T16633 TTD Target ID

    Gene Info:

    Publications:

  • Pharos: SSTR1

    • Version: 01-February-2022

    Alternate Names:
    Somatostatin receptor type 1 Gene Name
    P30872 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • GO: SSTR1

    • Version: 01-February-2022

    Alternate Names:

    Gene Info:

    Gene Categories:
    G PROTEIN COUPLED RECEPTOR

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21