6714 |
SRC PROTO-ONCOGENE, NON-RECEPTOR TYROSINE KINASE |
SRC |
ASV |
SRC1 |
THC6 |
c-SRC |
p60-Src |
190090 |
11283 |
ENSG00000197122 |
OTTHUMG00000032417 |
BE0000838 |
P12931 |
SRC_HUMAN |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC |
2206 |
NP_005408 |
NM_005417 |
pp60c-src |
Proto-oncogene c-Src |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (EC 2.7.1.112) (P60-SRC) (C-SRC). [SOURCE:UNIPROT/SWISSPROT;ACC:P12931] |
T85943 |
Human Readable Name | DRUGGABLE GENOME |
Human Readable Name | KINASE |
Interpro Acc | IPR001245 |
Uniprot Evidence | 1: Evidence at protein level |
Interpro Type | Domain |
Interpro Name | Serine-threonine/tyrosine-protein kinase catalytic domain |
Uniprot Status | Swiss-Prot |
Interpro Short Name | Ser-Thr/Tyr_kinase_cat_dom |
GuideToPharmacology Gene Category Name | Src family |
GuideToPharmacology Gene Category ID | 619 |
CancerCommons Reported Gene Name | SRC |
Target Main Class | Enzymes |
Target Subclass | 2.7.10.2 |
Initial Gene Query | SRC |
Counted Citations from 1950-2000 | 17440 |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
Gene Biotype | PROTEIN_CODING |
KINASE |
TYROSINE KINASE |
DRUG RESISTANCE |
DRUGGABLE GENOME |
CLINICALLY ACTIONABLE |
ENZYME |
TRANSCRIPTION FACTOR |
inhibitor (inhibitory) |
Details of the Assay for Interaction | Low affinity is expected because the peptide substrate binding site is not well formed when Src is isolated. |
Direct Interaction? | False |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Notes | |
Direct Interaction? | True |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase SRC inhibitor |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Notes | |
Trial Name | XL228 |
Novel drug target | Established target |
multitarget |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | SRC inhibitor |
Novel drug target | Established target |
inhibitor (inhibitory) |
Details of the Assay for Interaction | Measuring inhibition substrate phosphorylation by p60<sup>c-src</sup> tyrosine kinase in an ELISA, using an anti-phosphotyrosine detection antibody. |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
inhibitor (inhibitory) |
Evidence Type | Actionable |
Approval Status | Preclinical - Pdx |
Response Type | no benefit |
n/a |
Trial Name | masitinib, AB1010 |
Novel drug target | Established target |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | True |
inhibitor (inhibitory) |
Specific Action of the Ligand | Inhibition |
Endogenous Drug? | False |
Direct Interaction? | False |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
n/a |
Indication/Tumor Type | lung cancer |
Response Type | resistant |
Approval Status | Preclinical |
inhibitor (inhibitory) |
Direct Interaction? | False |
Endogenous Drug? | False |
Specific Action of the Ligand | Inhibition |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Direct Interaction | yes |
Mechanism of Interaction | Tyrosine-protein kinase SRC inhibitor |
inhibitor (inhibitory) |
Mechanism of Interaction | SRC inhibitor |
Direct Interaction | yes |
inhibitor (inhibitory) |
Mechanism of Interaction | Tyrosine-protein kinase SRC inhibitor |
Direct Interaction | yes |
SRC | Ensembl Gene Name |
Gene Biotype | PROTEIN_CODING |
SRC | Gene Symbol |
Target Class | Enzymes |
Target Subclass | EC:2.7.10.2 |
ENSG00000197122 | Ensembl Gene Id |
P12931 | Uniprot Accession |
SRC | Uniprot Gene Name |
Human Readable Name | DRUGGABLE GENOME |
Human Readable Name | KINASE |
Interpro Acc | IPR001245 |
KINASE, DRUGGABLE GENOME |
SRC | Gene Symbol |
SRC_HUMAN | Uniprot Id |
6714 | Entrez Gene Id |
Target Main Class | Enzymes |
Target Subclass | 2.7.10.2 |
6714 | Entrez Gene ID |
Initial Gene Query | SRC |
Counted Citations from 1950-2000 | 17440 |
KINASE |
PROTO-ONCOGENE TYROSINE-PROTEIN KINASE SRC (EC 2.7.1.112) (P60-SRC) (C-SRC). [SOURCE:UNIPROT/SWISSPROT;ACC:P12931] | Description |
SRC | Display Id |
ENSG00000197122 | Ensembl Gene Id |
Human Readable Name | DRUGGABLE GENOME |
DRUGGABLE GENOME |
6714 | Entrez Gene ID |
CancerCommons Reported Gene Name | SRC |
11283 | HUGO Gene ID |
11283 | HUGO Gene Symbol |
SRC proto-oncogene, non-receptor tyrosine kinase | HUGO Gene Name |
GuideToPharmacology Gene Category Name | Src family |
GuideToPharmacology Gene Category ID | 619 |
ENZYME |
6714 | CKB Entrez Id |
SRC | CKB Gene Synonym |
ASV | CKB Gene Synonym |
SRC | DrugBank Gene Name |
P12931 | UniProt Accession |
6714 | Entrez Gene Id |
C-SRC | Gene Symbol |
6714 | Entrez Gene Id |
SRC | MyCancerGenome Gene Symbol |
SRC | MyCancerGenome Reported Gene Name |
SRC | Gene Symbol |
ENSG00000197122 | Gene Symbol |
SRC | Ensembl Id |
DRUGGABLE GENOME |
SRC1 | GENE_SYMBOL |
SRC | GENE_SYMBOL |
Proto-oncogene tyrosine-protein kinase Src | UNIPROT |
Proto-oncogene tyrosine-protein kinase Src | Gene Name |
P12931 | UniProt ID |
KINASE, TRANSCRIPTION FACTOR |
SRC1 | GO Gene Synonym |
KINASE, TYROSINE KINASE, DRUG RESISTANCE |
SRC | Gene Symbol |
CLINICALLY ACTIONABLE |
6714 | Gene ID |
ASV | dGene Synonym |
SRC1 | dGene Synonym |
KINASE, TYROSINE KINASE |
SRC | TTD Gene Abbreviation |
T85943 | TTD Target ID |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |
CLINICALLY ACTIONABLE |