• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

SPP1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SPP1 6696 Druggable Genome

    Alternate Names:

    6696
    SECRETED PHOSPHOPROTEIN 1
    SPP1
    BNSP
    BSPI
    ETA-1
    OPN
    166490
    11255
    ENSG00000118785
    OTTHUMG00000130599
    Uropontin
    SPP-1
    Nephropontin
    Bone sialoprotein 1
    Osteopontin
    Urinary stone protein

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (0 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Zhang et al., 2003, [EGF/PI3K signaling pathway regulates the expression of osteopontin in liver cancer HepG2 cells]., Zhonghua Yi Xue Za Zhi
    Khanna, 2005, Tacrolimus and cyclosporinein vitro and in vivo induce osteopontin mRNA and protein expression in renal tissues., Nephron Exp. Nephrol.
    Chang et al., 2002, Novel protein kinase C isoforms and mitogen-activated kinase kinase mediate phorbol ester-induced osteopontin expression., Int. J. Biochem. Cell Biol.
    Verstrepen et al., 2001, Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat., Nephrol. Dial. Transplant.
    Kaji et al., 1994, Calcitonin inhibits osteopontin mRNA expression in isolated rabbit osteoclasts., Endocrinology
  • ASK-8007   SPP1

    Interaction Score: 10.3

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Osteopontin inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • CALCITONIN   SPP1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8013390


    Sources:
    NCI

  • ALTEPLASE   SPP1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12009309


    Sources:
    NCI

  • GENTAMICIN   SPP1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11274264


    Sources:
    NCI

  • WORTMANNIN   SPP1

    Interaction Score: 0.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14703434


    Sources:
    NCI

  • TACROLIMUS   SPP1

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16103732


    Sources:
    NCI

  • Ensembl: ENSG00000118785

    • Version: 101_38

    Alternate Names:
    SPP1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: SPP1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Khanna, 2005, Tacrolimus and cyclosporinein vitro and in vivo induce osteopontin mRNA and protein expression in renal tissues., Nephron Exp. Nephrol.
    Verstrepen et al., 2001, Renal osteopontin protein and mRNA upregulation during acute nephrotoxicity in the rat., Nephrol. Dial. Transplant.
    Kamiyoshi et al., 2005, Mycophenolate mofetil prevents the development of experimental autoimmune myocarditis., J. Mol. Cell. Cardiol.

  • HingoraniCasas: ENSG00000118785

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000118785 Gene Symbol
    SPP1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • ChemblInteractions: BNSP

    • Version: chembl_23

    Alternate Names:
    OPN GENE_SYMBOL
    SPP1 GENE_SYMBOL
    Osteopontin UNIPROT

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21