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SOD2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SOD2 6648 Druggable Genome

    Alternate Names:

    6648
    SUPEROXIDE DISMUTASE 2
    SOD2
    IPO-B
    IPOB
    MNSOD
    MVCD6
    Mn-SOD
    147460
    11180
    ENSG00000112096
    OTTHUMG00000015940
    P04179
    PA36017
    ENSG00000285441
    GClnc1

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME
    ENZYME

    Publications:

    Alachkar H et al., 2017, Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia., Pharmacogenomics J
    Boroumand F et al., 2018, Association of the SOD2 (rs2758339 and rs5746136) polymorphisms with the risk of heroin dependency and the SOD2 expression levels., Gene
    Bosó V et al., 2014, SNPs and taxane toxicity in breast cancer patients., Pharmacogenomics
    Barbisan F et al., 2014, Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism., PLoS One
  • DIACETYLMORPHINE   SOD2

    Interaction Score: 1.9

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29459008


    Sources:
    PharmGKB

  • ASPARAGINASE   SOD2

    Interaction Score: 1.65

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27019981


    Sources:
    PharmGKB

  • PACLITAXEL   SOD2

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25495407


    Sources:
    PharmGKB

  • METHOTREXATE   SOD2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25330300


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   SOD2

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000112096

    • Version: 101_38

    Alternate Names:
    SOD2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • PharmGKB: SOD2

    • Version: 18-August-2020

    Alternate Names:
    PA36017 PharmGKB ID

    Gene Info:

    Publications:
    Alachkar H et al., 2017, Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia., Pharmacogenomics J
    Bosó V et al., 2014, SNPs and taxane toxicity in breast cancer patients., Pharmacogenomics
    Barbisan F et al., 2014, Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism., PLoS One

  • NCI: SOD2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Kataoka et al., 2002, Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine., Int. J. Radiat. Oncol. Biol. Phys.

  • HingoraniCasas: ENSG00000112096

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000112096 Gene Symbol
    SOD2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SOD2

    • Version: 19.3

    Alternate Names:
    ENSG00000285441 Ensembl Gene ID
    Superoxide dismutase 2 Human Protein Atlas Gene Description
    P04179 UniProt ID

    Gene Info:

    Gene Categories:
    ENZYME

    Publications:

  • Tempus: SOD2

    • Version: 11-November-2018

    Alternate Names:
    SOD2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21