DGIdb - SOD2 Gene Record

SOD2 6648 Druggable Genome

Alternate Names:

6648
SUPEROXIDE DISMUTASE 2
SOD2
IPO-B
IPOB
MNSOD
MVCD6
Mn-SOD
147460
11180
ENSG00000112096
OTTHUMG00000015940
BE0004453
P04179
PA36017
ENSG00000285441

Gene Info:

Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

DRUGGABLE GENOME
ENZYME

Publications:

Alachkar H et al., 2017, Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia., Pharmacogenomics J
Boroumand F et al., 2018, Association of the SOD2 (rs2758339 and rs5746136) polymorphisms with the risk of heroin dependency and the SOD2 expression levels., Gene
Bosó V et al., 2014, SNPs and taxane toxicity in breast cancer patients., Pharmacogenomics
Barbisan F et al., 2014, Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism., PLoS One
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

CHEMBL1236909 SOD2

Interaction Score: 32.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
PHENYLMETHANESULFONIC ACID SOD2

Interaction Score: 10.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank
DIACETYLMORPHINE SOD2

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29459008

Sources:
PharmGKB
ASPARAGINASE SOD2

Interaction Score: 1.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27019981

Sources:
PharmGKB
PACLITAXEL SOD2

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25495407

Sources:
PharmGKB
METHOTREXATE SOD2

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25330300

Sources:
PharmGKB
CYCLOPHOSPHAMIDE SOD2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000112096
- Version: 101_38
Alternate Names:

SOD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SOD2

Version: 18-August-2020

Alternate Names:

PA36017 PharmGKB ID

Gene Info:

Publications:

Alachkar H et al., 2017, Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and asparaginase induced hepatotoxicity in adult patients with acute lymphoblastic leukemia., Pharmacogenomics J

Bosó V et al., 2014, SNPs and taxane toxicity in breast cancer patients., Pharmacogenomics

Barbisan F et al., 2014, Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism., PLoS One

DrugBank: BE0004453

Version: 5.1.7

Alternate Names:

SOD2 DrugBank Gene Name

P04179 UniProt Accession

6648 Entrez Gene Id

Gene Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: SOD2

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Kataoka et al., 2002, Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine., Int. J. Radiat. Oncol. Biol. Phys.

HingoraniCasas: ENSG00000112096
- Version: 31-May-2017
Alternate Names:

ENSG00000112096 Gene Symbol

SOD2 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
HumanProteinAtlas: SOD2
- Version: 19.3
Alternate Names:

ENSG00000285441 Ensembl Gene ID

Superoxide dismutase 2 Human Protein Atlas Gene Description

P04179 UniProt ID

Gene Info:

Gene Categories:

ENZYME

Publications:
Tempus: SOD2
- Version: 11-November-2018
Alternate Names:

SOD2 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

SOD2	DrugBank Gene Name
P04179	UniProt Accession
6648	Entrez Gene Id

ENSG00000285441	Ensembl Gene ID
Superoxide dismutase 2	Human Protein Atlas Gene Description
P04179	UniProt ID

SOD2 Gene Record

SOD2 6648 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

CHEMBL1236909 SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

PHENYLMETHANESULFONIC ACID SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10592235 17139284 17016423

Sources: DrugBank

DIACETYLMORPHINE SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29459008

Sources: PharmGKB

ASPARAGINASE SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27019981

Sources: PharmGKB

PACLITAXEL SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25495407

Sources: PharmGKB

METHOTREXATE SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25330300

Sources: PharmGKB

CYCLOPHOSPHAMIDE SOD2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000112096

Alternate Names: SOD2 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

PharmGKB: SOD2

Alternate Names: PA36017 PharmGKB ID

Gene Info:

DrugBank: BE0004453

Alternate Names: SOD2 DrugBank Gene Name P04179 UniProt Accession 6648 Entrez Gene Id

Gene Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

NCI: SOD2

Alternate Names:

Gene Info:

Publications: Kataoka et al., 2002, Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine., Int. J. Radiat. Oncol. Biol. Phys.

HingoraniCasas: ENSG00000112096

Alternate Names: ENSG00000112096 Gene Symbol SOD2 Ensembl Id

Gene Info:

Gene Categories: DRUGGABLE GENOME

Publications:

HumanProteinAtlas: SOD2

Alternate Names: ENSG00000285441 Ensembl Gene ID Superoxide dismutase 2 Human Protein Atlas Gene Description P04179 UniProt ID

Gene Info:

Gene Categories: ENZYME

Publications:

Tempus: SOD2

Alternate Names: SOD2 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
29459008

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27019981

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25495407

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25330300

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

SOD2 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

PA36017 PharmGKB ID

Alternate Names:

SOD2 DrugBank Gene Name

P04179 UniProt Accession

6648 Entrez Gene Id

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Publications:

Kataoka et al., 2002, Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine., Int. J. Radiat. Oncol. Biol. Phys.

Alternate Names:

ENSG00000112096 Gene Symbol

SOD2 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

ENSG00000285441 Ensembl Gene ID

Superoxide dismutase 2 Human Protein Atlas Gene Description

P04179 UniProt ID

Gene Categories:

ENZYME

Alternate Names:

SOD2 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE