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SOAT1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SOAT1 6646 Druggable Genome

    Alternate Names:

    6646
    STEROL O-ACYLTRANSFERASE 1
    SOAT1
    ACACT
    ACAT
    ACAT-1
    ACAT1
    SOAT
    STAT
    102642
    11177
    ENSG00000057252
    OTTHUMG00000035253
    STEROL O-ACYLTRANSFERASE 1 (EC 2.3.1.26) (CHOLESTEROL ACYLTRANSFERASE 1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE 1) (ACAT-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35610]
    P35610

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Target Class Enzymes
    Target Subclass EC:2.3.1.26
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    DRUGGABLE GENOME

    Publications:

    Robenek et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. II. Characterization of intracellular morphologic changes., Arteriosclerosis
    Schmitz et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. I. Characterization of cellular lipid metabolism., Arteriosclerosis
    Cheng et al., 1995, Dexamethasone enhances accumulation of cholesteryl esters by human macrophages., Am. J. Physiol.
    Azhar et al., 1989, The influence of estradiol on cholesterol processing by the corpus luteum., Biol. Reprod.
    Raal et al., 2003, Avasimibe, an ACAT inhibitor, enhances the lipid lowering effect of atorvastatin in subjects with homozygous familial hypercholesterolemia., Atherosclerosis
    Kam et al., 1990, Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells., Biochem. J.
  • NIFEDIPINE   SOAT1

    Interaction Score: 0.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3341992 2829803


    Sources:
    NCI

  • TESTOSTERONE   SOAT1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2765620


    Sources:
    NCI

  • LOVASTATIN   SOAT1

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2268271


    Sources:
    NCI

  • ATORVASTATIN   SOAT1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14644397


    Sources:
    NCI

  • DEXAMETHASONE   SOAT1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7485476


    Sources:
    NCI

  • Ensembl: ENSG00000057252

    • Version: 101_38

    Alternate Names:
    SOAT1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000057252

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000057252 Ensembl Gene Id
    STEROL O-ACYLTRANSFERASE 1 (EC 2.3.1.26) (CHOLESTEROL ACYLTRANSFERASE 1) (ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE 1) (ACAT-1). [SOURCE:UNIPROT/SWISSPROT;ACC:P35610] Description
    SOAT1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • TdgClinicalTrial: P35610

    • Version: January-2014

    Alternate Names:
    SOAT1 Gene Symbol

    Gene Info:
    Target Class Enzymes
    Target Subclass EC:2.3.1.26

    Publications:

  • NCI: SOAT1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Azhar et al., 1989, The influence of estradiol on cholesterol processing by the corpus luteum., Biol. Reprod.
    O'Meara et al., 1992, Alterations in cellular cholesterol metabolism following administration of 6-hydroxydopamine to rabbits., Br. J. Pharmacol.
    Robenek et al., Ca++ antagonists and ACAT inhibitors promote cholesterol efflux from macrophages by different mechanisms. II. Characterization of intracellular morphologic changes., Arteriosclerosis

  • HingoraniCasas: ENSG00000057252

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000057252 Gene Symbol
    SOAT1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21