DGIdb - SMARCA4 Gene Record

SMARCA4 6597 Clinically Actionable

Alternate Names:

6597
SWI/SNF RELATED, MATRIX ASSOCIATED, ACTIN DEPENDENT REGULATOR OF CHROMATIN, SUBFAMILY A, MEMBER 4
SMARCA4
BAF190
BAF190A
BRG1
CSS4
MRD16
RTPS2
SNF2
SNF2L4
SNF2LB
SWI2
hSNF2b
603254
11100
ENSG00000127616
OTTHUMG00000169272
P51532
78
2740
NM_001128849
NP_001122321
SNF2-beta
SNF2B

Gene Info:

Gene Biotype	PROTEIN_CODING
GuideToPharmacology Gene Category Name	Non-enzymatic BRD containing proteins
GuideToPharmacology Gene Category ID	867

(6 More Sources)

Gene Categories: Category Details

TRANSCRIPTION FACTOR BINDING
CLINICALLY ACTIONABLE

Publications:

Bell et al., 2016, SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer., Clin. Cancer Res.
Xue Y et al., 2019, SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer., Nat Commun
Xue Y et al., 2019, CDK4/6 inhibitors target SMARCA4-determined cyclin D1 deficiency in hypercalcemic small cell carcinoma of the ovary., Nat Commun
Italiano A et al., 2018, Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study., Lancet Oncol
Tagal V et al., 2017, SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers., Nat Commun

TAZEMETOSTAT SMARCA4

Interaction Score: 3.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29650362

Sources:
CIViC
ABEMACICLIB SMARCA4

Interaction Score: 1.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30718506 30718512

Sources:
CIViC
RIBOCICLIB SMARCA4

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30718512

Sources:
CIViC
VINORELBINE SMARCA4

Interaction Score: 0.7

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26671993

Sources:
CIViC
PALBOCICLIB SMARCA4

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30718506 30718512

Sources:
CIViC
TOZASERTIB SMARCA4

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28102363

Sources:
CIViC
CISPLATIN SMARCA4

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26671993

Sources:
CIViC

Ensembl: ENSG00000127616
- Version: 101_38
Alternate Names:

SMARCA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:
GuideToPharmacology: 6597
- Version: 29-September-2020
Alternate Names:

11100 HUGO Gene ID

11100 HUGO Gene Symbol

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Non-enzymatic BRD containing proteins

GuideToPharmacology Gene Category ID 867

Publications:

CIViC: SMARCA4

Version: 14-September-2020

Alternate Names:

6597 Entrez Gene ID

78 CIViC Gene ID

Gene Info:

Publications:

Tagal V et al., 2017, SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers., Nat Commun

Bell et al., 2016, SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer., Clin. Cancer Res.

Italiano A et al., 2018, Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study., Lancet Oncol

NCI: SMARCA4
- Version: 14-September-2017
Alternate Names:

Gene Info:

Publications:

Sumi-Ichinose et al., 1997, SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells., Mol. Cell. Biol.
Tempus: SMARCA4
- Version: 11-November-2018
Alternate Names:

SMARCA4 Gene Symbol

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
GO: SMARCA4
- Version: 01-May-2021
Alternate Names:

BAF190A GO Gene Synonym

BRG1 GO Gene Synonym

SNF2B GO Gene Synonym

Gene Info:

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Publications:
MskImpact: SMARCA4
- Version: May-2015
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
FoundationOneGenes: SMARCA4
- Version: 03-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
CarisMolecularIntelligence: SMARCA4
- Version: 04-September-2020
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:
Oncomine: SMARCA4
- Version: v3
Alternate Names:

Gene Info:

Gene Categories:

CLINICALLY ACTIONABLE

Publications:

11100	HUGO Gene ID
11100	HUGO Gene Symbol
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	HUGO Gene Name

BAF190A	GO Gene Synonym
BRG1	GO Gene Synonym
SNF2B	GO Gene Synonym

SMARCA4 Gene Record

SMARCA4 6597 Clinically Actionable

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

TAZEMETOSTAT SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29650362

Sources: CIViC

ABEMACICLIB SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30718506 30718512

Sources: CIViC

RIBOCICLIB SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30718512

Sources: CIViC

VINORELBINE SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26671993

Sources: CIViC

PALBOCICLIB SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30718506 30718512

Sources: CIViC

TOZASERTIB SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28102363

Sources: CIViC

CISPLATIN SMARCA4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26671993

Sources: CIViC

Ensembl: ENSG00000127616

Alternate Names: SMARCA4 Ensembl Gene Name

Gene Info: Gene Biotype PROTEIN_CODING

Publications:

GuideToPharmacology: 6597

Alternate Names: 11100 HUGO Gene ID 11100 HUGO Gene Symbol SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 HUGO Gene Name

Gene Info: GuideToPharmacology Gene Category Name Non-enzymatic BRD containing proteins GuideToPharmacology Gene Category ID 867

Publications:

CIViC: SMARCA4

Alternate Names: 6597 Entrez Gene ID 78 CIViC Gene ID

Gene Info:

NCI: SMARCA4

Alternate Names:

Gene Info:

Publications: Sumi-Ichinose et al., 1997, SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells., Mol. Cell. Biol.

Tempus: SMARCA4

Alternate Names: SMARCA4 Gene Symbol

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

GO: SMARCA4

Alternate Names: BAF190A GO Gene Synonym BRG1 GO Gene Synonym SNF2B GO Gene Synonym

Gene Info:

Gene Categories: TRANSCRIPTION FACTOR BINDING

Publications:

MskImpact: SMARCA4

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

FoundationOneGenes: SMARCA4

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Publications:

CarisMolecularIntelligence: SMARCA4

Alternate Names:

Gene Info:

Gene Categories: CLINICALLY ACTIONABLE

Interaction Types & Directionality:

n/a

PMIDs:
29650362

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
30718506 30718512

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
30718512

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
26671993

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
30718506 30718512

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
28102363

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
26671993

Sources:
CIViC

Alternate Names:

SMARCA4 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Alternate Names:

11100 HUGO Gene ID

11100 HUGO Gene Symbol

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name Non-enzymatic BRD containing proteins

GuideToPharmacology Gene Category ID 867

Alternate Names:

6597 Entrez Gene ID

78 CIViC Gene ID

Publications:

Sumi-Ichinose et al., 1997, SNF2beta-BRG1 is essential for the viability of F9 murine embryonal carcinoma cells., Mol. Cell. Biol.

Alternate Names:

SMARCA4 Gene Symbol

Gene Categories:

CLINICALLY ACTIONABLE

Alternate Names:

BAF190A GO Gene Synonym

BRG1 GO Gene Synonym

SNF2B GO Gene Synonym

Gene Categories:

TRANSCRIPTION FACTOR BINDING

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE

Gene Categories:

CLINICALLY ACTIONABLE