• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

SMAD2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SMAD2 4087 Clinically Actionable

    Alternate Names:

    4087
    SMAD FAMILY MEMBER 2
    SMAD2
    JV18
    JV18-1
    MADH2
    MADR2
    hMAD-2
    hSMAD2
    601366
    6768
    ENSG00000175387
    OTTHUMG00000132652
    CHTD8
    LDS6
    Q15796
    Mothers against decapentaplegic homolog 2

    Gene Info:

    Gene Biotype PROTEIN_CODING
    (5 More Sources)

    Gene Categories: Category Details

    TRANSCRIPTION FACTOR COMPLEX
    KINASE
    CLINICALLY ACTIONABLE

    Publications:

    Ko H, 2015, Geraniin inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration, invasion and anoikis resistance., Bioorg Med Chem Lett
    Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod
    Butts et al., 2005, Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid., Birth Defects Res. Part A Clin. Mol. Teratol.
    Higashiyama et al., 2007, Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis., Exp. Mol. Pathol.
    Ogias et al., 2006, Corticosteroids induce the differential expression of TGFbeta isoforms, receptors and signaling in the gastric mucosa of suckling rats., Regul. Pept.
    Segreto et al., 2002, Amifostine does not prevent activation of TGFbeta1 but induces smad 7 activation in megakaryocytes irradiated in vivo., Am. J. Hematol.
  • GERANIIN   SMAD2

    Interaction Score: 13.74

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26169124


    Sources:
    DTC

  • BLEOMYCIN   SMAD2

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17274978


    Sources:
    NCI

  • BISDEMETHOXYCURCUMIN   SMAD2

    Interaction Score: 4.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23145932


    Sources:
    DTC

  • AMIFOSTINE   SMAD2

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12410567


    Sources:
    NCI

  • DEMETHOXYCURCUMIN   SMAD2

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23145932


    Sources:
    DTC

  • BLEOMYCIN   SMAD2

    Interaction Score: 0.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17274978


    Sources:
    NCI

  • TRETINOIN   SMAD2

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15799023


    Sources:
    NCI

  • HYDROCORTISONE   SMAD2

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16644034


    Sources:
    NCI

  • CURCUMIN   SMAD2

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23145932


    Sources:
    DTC

  • Ensembl: ENSG00000175387

    • Version: 101_38

    Alternate Names:
    SMAD2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • NCI: SMAD2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Higashiyama et al., 2007, Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis., Exp. Mol. Pathol.
    Butts et al., 2005, Transforming growth factor-beta1 signaling participates in the physiological and pathological regulation of mouse inner ear development by all-trans retinoic acid., Birth Defects Res. Part A Clin. Mol. Teratol.
    Ogias et al., 2006, Corticosteroids induce the differential expression of TGFbeta isoforms, receptors and signaling in the gastric mucosa of suckling rats., Regul. Pept.

  • DTC: SMAD2

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Ko H, 2015, Geraniin inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration, invasion and anoikis resistance., Bioorg Med Chem Lett
    Wright LE et al., 2013, Curcuminoids block TGF-β signaling in human breast cancer cells and limit osteolysis in a murine model of breast cancer bone metastasis., J Nat Prod

  • GO: SMAD2

    • Version: 01-February-2022

    Alternate Names:
    MADH2 GO Gene Synonym
    MADR2 GO Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSCRIPTION FACTOR COMPLEX

    Publications:

  • Tempus: SMAD2

    • Version: 11-November-2018

    Alternate Names:
    SMAD2 Gene Symbol

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • Pharos: SMAD2

    • Version: 01-February-2022

    Alternate Names:
    Mothers against decapentaplegic homolog 2 Gene Name
    Q15796 UniProt ID

    Gene Info:

    Gene Categories:
    KINASE

    Publications:

  • MskImpact: SMAD2

    • Version: May-2015

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • FoundationOneGenes: SMAD2

    • Version: 03-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

  • CarisMolecularIntelligence: SMAD2

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Gene Categories:
    CLINICALLY ACTIONABLE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21