DGIdb - SLCO2B1 Gene Record

SLCO2B1 11309 Druggable Genome

Alternate Names:

11309
SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1
SLCO2B1
OATP-B
OATP2B1
OATPB
SLC21A9
604988
10962
ENSG00000137491
OTTHUMG00000165420
O94956
SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 2B1 (SOLUTE CARRIER FAMILY 21, MEMBER 9) (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94956]
PA35845

Gene Info:

Human Readable Name	DRUGGABLE GENOME
Gene Biotype	PROTEIN_CODING

(3 More Sources)

Gene Categories: Category Details

TRANSPORTER
DRUGGABLE GENOME

Publications:

Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos
Bachmakov et al., 2008, Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1., Diabetes
Imanaga J et al., 2011, The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans., Pharmacogenet Genomics
Tsamandouras N et al., 2014, Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach., Clin Pharmacol Ther
Kim KA et al., 2013, Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans., J Clin Pharmacol
Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics

SILICRISTIN SLCO2B1

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
SILYBIN B SLCO2B1

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
SILYDIANIN SLCO2B1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
FEXOFENADINE SLCO2B1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21280267

Sources:
PharmGKB
SCUTELLARIN SLCO2B1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22822035

Sources:
DTC
ISOSILYBIN A SLCO2B1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
ISOSILYBIN B SLCO2B1

Interaction Score: 2.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
SULFOBROMOPHTHALEIN SLCO2B1

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
ELTROMBOPAG SLCO2B1

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21422191

Sources:
DTC
MONTELUKAST SLCO2B1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23970434 19151602

Sources:
PharmGKB
SILIBININ SLCO2B1

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23401473

Sources:
DTC
ROSIGLITAZONE SLCO2B1

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18314419

Sources:
NCI
ROSUVASTATIN SLCO2B1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUVASTATIN SLCO2B1

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
SIMVASTATIN SLCO2B1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24598718

Sources:
PharmGKB
PRAVASTATIN SLCO2B1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LOVASTATIN SLCO2B1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ATORVASTATIN SLCO2B1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

Ensembl: ENSG00000137491
- Version: 101_38
Alternate Names:

SLCO2B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000137491

Version: 26-July-2011

Alternate Names:

SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 2B1 (SOLUTE CARRIER FAMILY 21, MEMBER 9) (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94956] Description

ENSG00000137491 Ensembl Gene Id

SLCO2B1 Display Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

PharmGKB: SLCO2B1

Version: 18-August-2020

Alternate Names:

PA35845 PharmGKB ID

Gene Info:

Publications:

Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics

Kim KA et al., 2013, Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans., J Clin Pharmacol

Imanaga J et al., 2011, The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans., Pharmacogenet Genomics

NCI: SLCO2B1

Version: 14-September-2017

Alternate Names:

Gene Info:

Publications:

Brown et al., 2007, Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo., J. Steroid Biochem. Mol. Biol.

Bachmakov et al., 2008, Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1., Diabetes

DTC: SLCO2B1

Version: 02-September-2020

Alternate Names:

Gene Info:

Publications:

Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos

Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos

Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos

HingoraniCasas: ENSG00000137491
- Version: 31-May-2017
Alternate Names:

ENSG00000137491 Gene Symbol

SLCO2B1 Ensembl Id

Gene Info:

Gene Categories:

DRUGGABLE GENOME

Publications:
Pharos: SLCO2B1
- Version: 01-February-2022
Alternate Names:

Solute carrier organic anion transporter family member 2B1 Gene Name

O94956 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:

SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 2B1 (SOLUTE CARRIER FAMILY 21, MEMBER 9) (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94956]	Description
ENSG00000137491	Ensembl Gene Id
SLCO2B1	Display Id

Solute carrier organic anion transporter family member 2B1	Gene Name
O94956	UniProt ID

SLCO2B1 Gene Record

SLCO2B1 11309 Druggable Genome

Alternate Names:

Gene Info:

Gene Categories: Category Details

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21280267

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22822035

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21422191

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23970434 19151602

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23401473

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18314419

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24598718

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Ensembl: ENSG00000137491

Alternate Names: SLCO2B1 Ensembl Gene Name

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21280267

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22822035

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
21422191

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23970434 19151602

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23401473

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
18314419

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
24598718

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

SLCO2B1 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

PA35845 PharmGKB ID

Alternate Names:

ENSG00000137491 Gene Symbol

SLCO2B1 Ensembl Id

Gene Categories:

DRUGGABLE GENOME

Alternate Names:

Solute carrier organic anion transporter family member 2B1 Gene Name

O94956 UniProt ID

Gene Categories:

TRANSPORTER