• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

SLCO2B1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLCO2B1 11309 Druggable Genome

    Alternate Names:

    11309
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1
    SLCO2B1
    OATP-B
    OATP2B1
    OATPB
    SLC21A9
    604988
    10962
    ENSG00000137491
    OTTHUMG00000165420
    O94956
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 2B1 (SOLUTE CARRIER FAMILY 21, MEMBER 9) (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94956]
    PA35845

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (3 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos
    Bachmakov et al., 2008, Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1., Diabetes
    Imanaga J et al., 2011, The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans., Pharmacogenet Genomics
    Tsamandouras N et al., 2014, Identification of the effect of multiple polymorphisms on the pharmacokinetics of simvastatin and simvastatin acid using a population-modeling approach., Clin Pharmacol Ther
    Kim KA et al., 2013, Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans., J Clin Pharmacol
    Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics
  • SILICRISTIN   SLCO2B1

    Interaction Score: 6.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SILYBIN B   SLCO2B1

    Interaction Score: 3.43

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SILYDIANIN   SLCO2B1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • FEXOFENADINE   SLCO2B1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21280267


    Sources:
    PharmGKB

  • SCUTELLARIN   SLCO2B1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22822035


    Sources:
    DTC

  • ISOSILYBIN A   SLCO2B1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • ISOSILYBIN B   SLCO2B1

    Interaction Score: 2.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SULFOBROMOPHTHALEIN   SLCO2B1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • ELTROMBOPAG   SLCO2B1

    Interaction Score: 0.98

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • MONTELUKAST   SLCO2B1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23970434 19151602


    Sources:
    PharmGKB

  • SILIBININ   SLCO2B1

    Interaction Score: 0.57

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • ROSIGLITAZONE   SLCO2B1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18314419


    Sources:
    NCI

  • ROSUVASTATIN   SLCO2B1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUVASTATIN   SLCO2B1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • SIMVASTATIN   SLCO2B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24598718


    Sources:
    PharmGKB

  • PRAVASTATIN   SLCO2B1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOVASTATIN   SLCO2B1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ATORVASTATIN   SLCO2B1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • Ensembl: ENSG00000137491

    • Version: 101_38

    Alternate Names:
    SLCO2B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000137491

    • Version: 26-July-2011

    Alternate Names:
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 2B1 (SOLUTE CARRIER FAMILY 21, MEMBER 9) (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2). [SOURCE:UNIPROT/SWISSPROT;ACC:O94956] Description
    ENSG00000137491 Ensembl Gene Id
    SLCO2B1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLCO2B1

    • Version: 18-August-2020

    Alternate Names:
    PA35845 PharmGKB ID

    Gene Info:

    Publications:
    Mougey EB et al., 2009, Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response., Pharmacogenet Genomics
    Kim KA et al., 2013, Effects of polymorphisms of the SLCO2B1 transporter gene on the pharmacokinetics of montelukast in humans., J Clin Pharmacol
    Imanaga J et al., 2011, The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans., Pharmacogenet Genomics

  • NCI: SLCO2B1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Brown et al., 2007, Down-regulation of messenger ribonucleic acid encoding an importer of sulfoconjugated steroids during human chorionic gonadotropin-induced follicular luteinization in vivo., J. Steroid Biochem. Mol. Biol.
    Bachmakov et al., 2008, Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1., Diabetes

  • DTC: SLCO2B1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Gao C et al., 2012, Mechanistic studies on the absorption and disposition of scutellarin in humans: selective OATP2B1-mediated hepatic uptake is a likely key determinant for its unique pharmacokinetic characteristics., Drug Metab Dispos

  • HingoraniCasas: ENSG00000137491

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000137491 Gene Symbol
    SLCO2B1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: SLCO2B1

    • Version: 01-February-2022

    Alternate Names:
    Solute carrier organic anion transporter family member 2B1 Gene Name
    O94956 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21