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SLCO1B1 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLCO1B1 10599 Druggable Genome

    Alternate Names:

    10599
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B1
    SLCO1B1
    HBLRR
    LST-1
    LST1
    OATP-C
    OATP1B1
    OATP2
    OATPC
    SLC21A6
    604843
    10959
    ENSG00000134538
    OTTHUMG00000169047
    Q9Y6L6
    PA134865839
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B1 (SOLUTE CARRIER FAMILY 21, MEMBER 6) (SODIUM-INDEPENDENT ORGANIC ANION TRANSPORTING POLYPEPTIDE 2) (OATP 2) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 1) (LST-1) (OATP-C). [SOURCE:UNIPROT/SWISSPRO
    8450

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (6 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Mei Y et al., 2015, Role of SLCO1B1, ABCB1, and CHRNA1 gene polymorphisms on the efficacy of rocuronium in Chinese patients., J Clin Pharmacol
    Varenhorst C et al., 2015, Effect of genetic variations on ticagrelor plasma levels and clinical outcomes., Eur Heart J
    Yamazaki et al., 2005, Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport., Xenobiotica
    Katz DA et al., 2006, Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics., Clin Pharmacol Ther
    Kwara A et al., 2014, Factors associated with variability in rifampin plasma pharmacokinetics and the relationship between rifampin concentrations and induction of efavirenz clearance., Pharmacotherapy
    Li LM et al., 2012, SLCO1B1 *15 haplotype is associated with rifampin-induced liver injury., Mol Med Rep
    Chigutsa E et al., 2011, The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications., Antimicrob Agents Chemother
    He YJ et al., 2009, Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism., Clin Chim Acta
    Vavricka et al., 2002, Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver., Hepatology
    Varma MV et al., 2015, Quantitative Rationalization of Gemfibrozil Drug Interactions: Consideration of Transporters-Enzyme Interplay and the Role of Circulating Metabolite Gemfibrozil 1-O-β-Glucuronide., Drug Metab Dispos
    Sharma P et al., 2010, Validation of cell-based OATP1B1 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions., Xenobiotica
    Drenberg CD et al., 2016, Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia., Clin Pharmacol Ther
    Kalliokoski A et al., 2008, Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide., J Clin Pharmacol
    Kameyama Y et al., 2005, Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells., Pharmacogenet Genomics
    Iacobucci I et al., 2013, Profiling of drug-metabolizing enzymes/transporters in CD33+ acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine, Cytarabine and Idarubicin., Pharmacogenomics J
    Treiber et al., 2007, Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil., Drug Metab. Dispos.
    Oh ES et al., 2013, Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans., Drug Metab Pharmacokinet
    Wen J et al., 2010, OATP1B1 388A>G polymorphism and pharmacokinetics of pitavastatin in Chinese healthy volunteers., J Clin Pharm Ther
    Hirano M et al., 2004, Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans., J Pharmacol Exp Ther
    Hirano M et al., 2006, Drug-drug interaction between pitavastatin and various drugs via OATP1B1., Drug Metab Dispos
    Han JY et al., 2009, Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer., Lung Cancer
    Dawed AY et al., 2016, CYP2C8 and SLCO1B1 Variants and Therapeutic Response to Thiazolidinediones in Patients With Type 2 Diabetes., Diabetes Care
    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Liu L et al., 2006, Vectorial transport of enalapril by Oatp1a1/Mrp2 and OATP1B1 and OATP1B3/MRP2 in rat and human livers., J Pharmacol Exp Ther
    Nozawa et al., 2004, Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity., Drug Metab. Dispos.
    Reimer T et al., 2016, SLCO1B1*5 polymorphism (rs4149056) is associated with chemotherapy-induced amenorrhea in premenopausal women with breast cancer: a prospective cohort study., BMC Cancer
    Smith et al., 2005, Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel., Cancer Biol. Ther.
    Radtke et al., 2013, Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia., Blood
    Eldem İ et al., 2018, SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy., J Pediatr Hematol Oncol
    Liu SG et al., 2017, Polymorphisms in methotrexate transporters and their relationship to plasma methotrexate levels, toxicity of high-dose methotrexate, and outcome of pediatric acute lymphoblastic leukemia., Oncotarget
    Moriyama T et al., 2015, Inherited genetic variation in childhood acute lymphoblastic leukemia., Blood
    Goričar K et al., 2014, Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma., Pharmacogenet Genomics
    Csordas K et al., 2014, Associations of novel genetic variations in the folate-related and ARID5B genes with the pharmacokinetics and toxicity of high-dose methotrexate in paediatric acute lymphoblastic leukaemia., Br J Haematol
    Ramsey LB et al., 2013, Genome-wide study of methotrexate clearance replicates SLCO1B1., Blood
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Treviño LR et al., 2009, Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects., J Clin Oncol
    Tirona RG et al., 2001, Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans., J Biol Chem
    Sandhu P et al., 2005, Hepatic uptake of the novel antifungal agent caspofungin., Drug Metab Dispos
    Igel et al., 2006, Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin., Clin. Pharmacol. Ther.
    Marcath LA et al., 2019, Patients carrying CYP2C8*3 have shorter systemic paclitaxel exposure., Pharmacogenomics
    Kobie J et al., 2019, Pharmacogenetic Analysis of OATP1B1, UGT1A1, and BCRP Variants in Relation to the Pharmacokinetics of Letermovir in Previously Conducted Clinical Studies., J Clin Pharmacol
    Suwannakul S et al., 2008, Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism., J Hum Genet
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem
    Maeda K et al., 2006, Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril., Clin Pharmacol Ther
    Dragović G et al., 2020, Influence of SLCO1B1 polymorphisms on lopinavir C<sub>trough</sub> in Serbian HIV/AIDS patients., Br J Clin Pharmacol
    Bins S et al., 2016, Polymorphisms in SLCO1B1 and UGT1A1 are associated with sorafenib-induced toxicity., Pharmacogenomics
    Tornio A et al., 2015, SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid., Pharmacogenet Genomics
    Thompson JF et al., 2005, An association study of 43 SNPs in 16 candidate genes with atorvastatin response., Pharmacogenomics J
    Hsiang B et al., 1999, A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters., J Biol Chem
    Chen et al., 2005, Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1., Drug Metab. Dispos.
    Lau et al., 2007, effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers., Clin. Pharmacol. Ther.
  • CASPOFUNGIN   SLCO1B1

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15716364


    Sources:
    PharmGKB

  • PITAVASTATIN   SLCO1B1

    Interaction Score: 1.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23007012 20175818 15159445 16595711


    Sources:
    PharmGKB

  • VALSARTAN   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16678545


    Sources:
    PharmGKB

  • OLMESARTAN   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18641915


    Sources:
    PharmGKB

  • LETERMOVIR   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31022310


    Sources:
    PharmGKB

  • ELAGOLIX   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • SILYBIN B   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • ATRASENTAN   SLCO1B1

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16513443


    Sources:
    PharmGKB

  • MK-8245   SLCO1B1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21661758


    Sources:
    DTC

  • ISOSILYBIN A   SLCO1B1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • ISOSILYBIN B   SLCO1B1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • SILYDIANIN   SLCO1B1

    Interaction Score: 0.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • BOSENTAN   SLCO1B1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17496208


    Sources:
    PharmGKB

  • CERIVASTATIN   SLCO1B1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15970799


    Sources:
    PharmGKB

  • GEMFIBROZIL   SLCO1B1

    Interaction Score: 0.48

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    16316932 25941268 19919292


    Sources:
    NCI

  • ROCURONIUM   SLCO1B1

    Interaction Score: 0.4

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25279974


    Sources:
    PharmGKB

  • RIFAMPIN   SLCO1B1

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    24420746 22562052 21709081 19374892 12085361


    Sources:
    PharmGKB

  • ELTROMBOPAG   SLCO1B1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • SULFOBROMOPHTHALEIN   SLCO1B1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21422191


    Sources:
    DTC

  • TICAGRELOR   SLCO1B1

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25935875


    Sources:
    PharmGKB

  • AMPRENAVIR   SLCO1B1

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • LOPINAVIR   SLCO1B1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32022294


    Sources:
    PharmGKB

  • NATEGLINIDE   SLCO1B1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18187595


    Sources:
    PharmGKB

  • SILIBININ   SLCO1B1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23401473


    Sources:
    DTC

  • CLOFIBRATE   SLCO1B1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16316932


    Sources:
    NCI

  • TROGLITAZONE   SLCO1B1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14977862


    Sources:
    NCI PharmGKB

  • LOVASTATIN   SLCO1B1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26020121 16103896 10601278 15616150


    Sources:
    PharmGKB

  • METHOTREXATE   SLCO1B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23652803 29683944 28525903 25999454 25098908 24712521 23233662 21317831 19901119 11477075


    Sources:
    CIViC PharmGKB

  • SIMEPREVIR   SLCO1B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • ATAZANAVIR   SLCO1B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FLUDARABINE   SLCO1B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • FENOFIBRATE   SLCO1B1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16316932


    Sources:
    NCI PharmGKB

  • ENALAPRIL   SLCO1B1

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16627748


    Sources:
    PharmGKB

  • ROSIGLITAZONE   SLCO1B1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27271184


    Sources:
    PharmGKB

  • ROSUVASTATIN   SLCO1B1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    FDA

  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN   SLCO1B1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18221820


    Sources:
    PharmGKB

  • CYTARABINE   SLCO1B1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26663398 22584460


    Sources:
    PharmGKB

  • EPIRUBICIN   SLCO1B1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27234217


    Sources:
    PharmGKB

  • PRAVASTATIN   SLCO1B1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16678544


    Sources:
    NCI

  • MERCAPTOPURINE   SLCO1B1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29683944


    Sources:
    PharmGKB

  • IDARUBICIN   SLCO1B1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • DOCETAXEL   SLCO1B1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16210916 27234217


    Sources:
    NCI PharmGKB

  • MITOXANTRONE   SLCO1B1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26663398


    Sources:
    PharmGKB

  • ETOPOSIDE   SLCO1B1

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26663398


    Sources:
    PharmGKB

  • ATORVASTATIN   SLCO1B1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17192770


    Sources:
    NCI

  • DAUNORUBICIN   SLCO1B1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26663398


    Sources:
    PharmGKB

  • RUCAPARIB   SLCO1B1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • CYCLOPHOSPHAMIDE   SLCO1B1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27234217


    Sources:
    PharmGKB

  • SORAFENIB   SLCO1B1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27533851


    Sources:
    PharmGKB

  • DOXORUBICIN   SLCO1B1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27234217


    Sources:
    PharmGKB

  • PACLITAXEL   SLCO1B1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30520341


    Sources:
    PharmGKB

  • FLUOROURACIL   SLCO1B1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27234217


    Sources:
    PharmGKB

  • Ensembl: ENSG00000134538

    • Version: 101_38

    Alternate Names:
    SLCO1B1 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000134538

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000134538 Ensembl Gene Id
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1B1 (SOLUTE CARRIER FAMILY 21, MEMBER 6) (SODIUM-INDEPENDENT ORGANIC ANION TRANSPORTING POLYPEPTIDE 2) (OATP 2) (LIVER-SPECIFIC ORGANIC ANION TRANSPORTER 1) (LST-1) (OATP-C). [SOURCE:UNIPROT/SWISSPRO Description
    SLCO1B1 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLCO1B1

    • Version: 18-August-2020

    Alternate Names:
    PA134865839 PharmGKB ID

    Gene Info:

    Publications:
    Varenhorst C et al., 2015, Effect of genetic variations on ticagrelor plasma levels and clinical outcomes., Eur Heart J
    Drenberg CD et al., 2016, Inherited variation in OATP1B1 is associated with treatment outcome in acute myeloid leukemia., Clin Pharmacol Ther
    Hirano M et al., 2004, Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans., J Pharmacol Exp Ther

  • CIViC: SLCO1B1

    • Version: 14-September-2020

    Alternate Names:
    10599 Entrez Gene ID
    8450 CIViC Gene ID

    Gene Info:

    Publications:
    Radtke et al., 2013, Germline genetic variations in methotrexate candidate genes are associated with pharmacokinetics, toxicity, and outcome in childhood acute lymphoblastic leukemia., Blood

  • NCI: SLCO1B1

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Yamazaki et al., 2005, Effects of fibrates on human organic anion-transporting polypeptide 1B1-, multidrug resistance protein 2- and P-glycoprotein-mediated transport., Xenobiotica
    Igel et al., 2006, Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin., Clin. Pharmacol. Ther.
    Nozawa et al., 2004, Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity., Drug Metab. Dispos.

  • DTC: SLCO1B1

    • Version: 02-September-2020

    Alternate Names:

    Gene Info:

    Publications:
    Köck K et al., 2013, Interaction of silymarin flavonolignans with organic anion-transporting polypeptides., Drug Metab Dispos
    Takeuchi K et al., 2011, Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent., Drug Metab Dispos
    Oballa RM et al., 2011, Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia., J Med Chem

  • HingoraniCasas: ENSG00000134538

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000134538 Gene Symbol
    SLCO1B1 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SLCO1B1

    • Version: 19.3

    Alternate Names:
    ENSG00000134538 Ensembl Gene ID
    LST-1 Human Protein Atlas Gene Synonym
    OATP-C Human Protein Atlas Gene Synonym

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • Pharos: SLCO1B1

    • Version: 01-February-2022

    Alternate Names:
    Solute carrier organic anion transporter family member 1B1 Gene Name
    Q9Y6L6 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • FDA: SLCO1B1

    • Version: 04-September-2020

    Alternate Names:

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21