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SLCO1A2 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLCO1A2 6579 Druggable Genome

    Alternate Names:

    6579
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1A2
    SLCO1A2
    OATP
    OATP-A
    OATP1A2
    SLC21A3
    602883
    10956
    ENSG00000084453
    OTTHUMG00000156259
    P46721
    PA328
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1A2 (SOLUTE CARRIER FAMILY 21, MEMBER 3) (SODIUM-INDEPENDENT ORGANIC ANION TRANSPORTER) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 1) (OATP1) (OATP- A). [SOURCE:UNIPROT/SWISSPROT;ACC:P46721]

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Lu et al., 1996, Regulation of renal oatp mRNA expression by testosterone., Am. J. Physiol.
    Costa ACC et al., 2017, The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries., Eur J Clin Pharmacol
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics
    Yamakawa Y et al., 2011, Pharmacokinetic impact of SLCO1A2 polymorphisms on imatinib disposition in patients with chronic myeloid leukemia., Clin Pharmacol Ther
    Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther
  • NADOLOL   SLCO1A2

    Interaction Score: 6.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24419562


    Sources:
    PharmGKB

  • ROCURONIUM   SLCO1A2

    Interaction Score: 4.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28409297


    Sources:
    PharmGKB

  • TESTOSTERONE   SLCO1A2

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8779895


    Sources:
    NCI

  • IMATINIB   SLCO1A2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21633340


    Sources:
    PharmGKB

  • METHOTREXATE   SLCO1A2

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21317831


    Sources:
    PharmGKB

  • Ensembl: ENSG00000084453

    • Version: 101_38

    Alternate Names:
    SLCO1A2 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000084453

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000084453 Ensembl Gene Id
    SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1A2 (SOLUTE CARRIER FAMILY 21, MEMBER 3) (SODIUM-INDEPENDENT ORGANIC ANION TRANSPORTER) (ORGANIC ANION TRANSPORTING POLYPEPTIDE 1) (OATP1) (OATP- A). [SOURCE:UNIPROT/SWISSPROT;ACC:P46721] Description
    SLCO1A2 Display Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • PharmGKB: SLCO1A2

    • Version: 18-August-2020

    Alternate Names:
    PA328 PharmGKB ID

    Gene Info:

    Publications:
    Misaka S et al., 2014, Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects., Clin Pharmacol Ther
    Costa ACC et al., 2017, The SLCO1A2 -189_-188InsA polymorphism reduces clearance of rocuronium in patients submitted to elective surgeries., Eur J Clin Pharmacol
    Mikkelsen TS et al., 2011, PharmGKB summary: methotrexate pathway., Pharmacogenet Genomics

  • NCI: SLCO1A2

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Lu et al., 1996, Regulation of renal oatp mRNA expression by testosterone., Am. J. Physiol.
    Kanai et al., 1996, Estradiol 17 beta-D-glucuronide is a high-affinity substrate for oatp organic anion transporter., Am. J. Physiol.

  • HingoraniCasas: ENSG00000084453

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000084453 Gene Symbol
    SLCO1A2 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • Pharos: SLCO1A2

    • Version: 01-February-2022

    Alternate Names:
    Solute carrier organic anion transporter family member 1A2 Gene Name
    P46721 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21