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SLC9A3 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC9A3 6550 Druggable Genome

    Alternate Names:

    6550
    SOLUTE CARRIER FAMILY 9 MEMBER A3
    SLC9A3
    DIAR8
    NHE-3
    NHE3
    182307
    11073
    ENSG00000066230
    OTTHUMG00000090315
    Sodium/hydrogen exchanger 3
    Solute carrier family 9 member 3
    Na(+)/H(+) exchanger 3
    950
    P48764
    SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXCHANGER 3) (NHE-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P48764]
    SL9A3_HUMAN
    T92403
    BE0009757

    Gene Info:

    GuideToPharmacology Gene Category Name SLC9 family of sodium/hydrogen exchangers
    GuideToPharmacology Gene Category ID 181
    Human Readable Name DRUGGABLE GENOME
    Interpro Name Cation/H+ exchanger
    Interpro Short Name Cation/H_exchanger
    Uniprot Evidence 1: Evidence at protein level
    Interpro Type Family
    Human Readable Name EXCHANGER
    Uniprot Status Swiss-Prot
    Interpro Acc IPR004709
    Interpro Acc IPR006153
    Interpro Name Na+/H+ exchanger
    Interpro Type Domain
    Interpro Short Name NaH_exchanger
    Gene Biotype PROTEIN_CODING
    (7 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    CELL SURFACE
    DRUGGABLE GENOME
    EXCHANGER

    Publications:

    Gekle et al., 2001, Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion., J. Physiol. (Lond.)
    Drumm et al., 2001, Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells)., Eur. J. Med. Res.
  • TENAPANOR HYDROCHLORIDE   SLC9A3

    Interaction Score: 37.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Sodium/hydrogen exchanger 3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    TTD ChemblInteractions

  • TENAPANOR   SLC9A3

    Interaction Score: 18.94

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ALBUMIN HUMAN   SLC9A3

    Interaction Score: 3.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11251045 11698229


    Sources:
    NCI

  • Ensembl: ENSG00000066230

    • Version: 101_38

    Alternate Names:
    SLC9A3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000066230

    • Version: 26-July-2011

    Alternate Names:
    SLC9A3 Display Id
    SODIUM/HYDROGEN EXCHANGER 3 (NA(+)/H(+) EXCHANGER 3) (NHE-3). [SOURCE:UNIPROT/SWISSPROT;ACC:P48764] Description
    ENSG00000066230 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HopkinsGroom: P48764

    • Version: 11-September-2012

    Alternate Names:
    SL9A3_HUMAN Uniprot Id
    6550 Entrez Gene Id
    ENSG00000066230 Ensembl Gene Id

    Gene Info:
    Interpro Name Cation/H+ exchanger
    Interpro Short Name Cation/H_exchanger
    Uniprot Evidence 1: Evidence at protein level

    Gene Categories:
    DRUGGABLE GENOME, EXCHANGER

    Publications:

  • GuideToPharmacology: 6550

    • Version: 29-September-2020

    Alternate Names:
    11073 HUGO Gene ID
    11073 HUGO Gene Symbol
    solute carrier family 9 member A3 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name SLC9 family of sodium/hydrogen exchangers
    GuideToPharmacology Gene Category ID 181

    Gene Categories:
    TRANSPORTER

    Publications:

  • NCI: SLC9A3

    • Version: 14-September-2017

    Alternate Names:

    Gene Info:

    Publications:
    Loffing et al., 1998, Renal Na/H exchanger NHE-3 and Na-PO4 cotransporter NaPi-2 protein expression in glucocorticoid excess and deficient states., J. Am. Soc. Nephrol.
    Gekle et al., 2001, Inhibition of Na+-H+ exchanger-3 interferes with apical receptor-mediated endocytosis via vesicle fusion., J. Physiol. (Lond.)
    Drumm et al., 2001, Inhibition of Na superset+/H superset+ exchange decreases albumin-induced NF-kappaB activation in renal proximal tubular cell lines (OK and LLC-PK1 cells)., Eur. J. Med. Res.

  • ChemblInteractions: NHE3

    • Version: chembl_23

    Alternate Names:
    NHE3 GENE_SYMBOL
    SLC9A3 GENE_SYMBOL
    Sodium/hydrogen exchanger 3 UNIPROT

    Gene Info:

    Publications:

  • HingoraniCasas: ENSG00000066230

    • Version: 31-May-2017

    Alternate Names:
    ENSG00000066230 Gene Symbol
    SLC9A3 Ensembl Id

    Gene Info:

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • HumanProteinAtlas: SLC9A3

    • Version: 19.3

    Alternate Names:
    ENSG00000066230 Ensembl Gene ID
    NHE3 Human Protein Atlas Gene Synonym
    Solute carrier family 9 member A3 Human Protein Atlas Gene Description

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC9A3

    • Version: 05-September-2020

    Alternate Names:
    NHE3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    CELL SURFACE

    Publications:

  • DrugBank: BE0009757

    • Version: 5.1.7

    Alternate Names:
    SLC9A3 DrugBank Gene Name
    P48764 UniProt Accession
    6550 Entrez Gene Id

    Gene Info:

    Publications:

  • TTD: Sodium/hydrogen exchanger 3

    • Version: 2020.06.01

    Alternate Names:
    SLC9A3 TTD Gene Abbreviation
    T92403 TTD Target ID

    Gene Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21