• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

SLC7A4 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC7A4 6545 Druggable Genome

    Alternate Names:

    6545
    SOLUTE CARRIER FAMILY 7 MEMBER 4
    SLC7A4
    CAT-4
    CAT4
    HCAT3
    VH
    603752
    11062
    ENSG00000099960
    OTTHUMG00000150896
    O43246
    SOLUTE CARRIER FAMILY 7 (CATIONIC AMINO ACID TRANSPORTER, Y+ SYSTEM), MEMBER 4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004164]
    NP_004164.1
    BE0000052
    894
    Cationic amino acid transporter 4

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169
    Gene Biotype PROTEIN_CODING
    (1 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    DRUGGABLE GENOME

    Publications:

    Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
    Rotoli et al., 2005, The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors., FASEB J.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • LYSINE   SLC7A4

    Interaction Score: 16.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15746185 17139284 17016423


    Sources:
    DrugBank

  • ARGININE   SLC7A4

    Interaction Score: 5.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329401


    Sources:
    DrugBank

  • Ensembl: ENSG00000099960

    • Version: 101_38

    Alternate Names:
    SLC7A4 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000099960

    • Version: 26-July-2011

    Alternate Names:
    ENSG00000099960 Ensembl Gene Id
    NP_004164.1 Display Id
    SOLUTE CARRIER FAMILY 7 (CATIONIC AMINO ACID TRANSPORTER, Y+ SYSTEM), MEMBER 4 [SOURCE:REFSEQ_PEPTIDE;ACC:NP_004164] Description

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 6545

    • Version: 29-September-2020

    Alternate Names:
    11062 HUGO Gene ID
    11062 HUGO Gene Symbol
    solute carrier family 7 member 4 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169

    Gene Categories:
    TRANSPORTER

    Publications:

  • DrugBank: BE0000052

    • Version: 5.1.7

    Alternate Names:
    SLC7A4 DrugBank Gene Name
    O43246 UniProt Accession
    6545 Entrez Gene Id

    Gene Info:

    Publications:
    Rotoli et al., 2005, The transport of cationic amino acids in human airway cells: expression of system y+L activity and transepithelial delivery of NOS inhibitors., FASEB J.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

  • Pharos: SLC7A4

    • Version: 03-September-2020

    Alternate Names:
    Cationic amino acid transporter 4 Gene Name
    O43246 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21