• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

SLC7A3 Gene Record

  • Summary
  • Interactions
  • Claims
  • SLC7A3 84889 Druggable Genome

    Alternate Names:

    84889
    SOLUTE CARRIER FAMILY 7 MEMBER 3
    SLC7A3
    ATRC3
    CAT-3
    CAT3
    300443
    11061
    ENSG00000165349
    OTTHUMG00000021780
    CATIONIC AMINO ACID TRANSPORTER 3 (CAT-3) (SOLUTE CARRIER FAMILY 7 MEMBER 3) (CATIONIC AMINO ACID TRANSPORTER Y+). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8WY07]
    CTR3_HUMAN
    BE0000136
    Q8WY07
    893
    Cationic amino acid transporter 3

    Gene Info:

    Human Readable Name DRUGGABLE GENOME
    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169
    Gene Biotype PROTEIN_CODING
    (2 More Sources)

    Gene Categories: Category Details

    TRANSPORTER
    EXTERNAL SIDE OF PLASMA MEMBRANE
    DRUGGABLE GENOME

    Publications:

    Huang et al., 2007, The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway., J. Neurosci.
    Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
    Hosokawa et al., 1997, Cloning and characterization of a brain-specific cationic amino acid transporter., J. Biol. Chem.
    Humphrey et al., 2006, Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
  • LYSINE   SLC7A3

    Interaction Score: 20.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9079705 16406639 17139284 17016423


    Sources:
    DrugBank

  • ARGININE   SLC7A3

    Interaction Score: 8.52

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17234578 17329401


    Sources:
    DrugBank

  • Ensembl: ENSG00000165349

    • Version: 101_38

    Alternate Names:
    SLC7A3 Ensembl Gene Name

    Gene Info:
    Gene Biotype PROTEIN_CODING

    Publications:

  • RussLampel: ENSG00000165349

    • Version: 26-July-2011

    Alternate Names:
    CTR3_HUMAN Display Id
    CATIONIC AMINO ACID TRANSPORTER 3 (CAT-3) (SOLUTE CARRIER FAMILY 7 MEMBER 3) (CATIONIC AMINO ACID TRANSPORTER Y+). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8WY07] Description
    ENSG00000165349 Ensembl Gene Id

    Gene Info:
    Human Readable Name DRUGGABLE GENOME

    Gene Categories:
    DRUGGABLE GENOME

    Publications:

  • GuideToPharmacology: 84889

    • Version: 29-September-2020

    Alternate Names:
    11061 HUGO Gene ID
    11061 HUGO Gene Symbol
    solute carrier family 7 member 3 HUGO Gene Name

    Gene Info:
    GuideToPharmacology Gene Category Name SLC7 family
    GuideToPharmacology Gene Category ID 169

    Gene Categories:
    TRANSPORTER

    Publications:

  • DrugBank: BE0000136

    • Version: 5.1.7

    Alternate Names:
    SLC7A3 DrugBank Gene Name
    Q8WY07 UniProt Accession
    84889 Entrez Gene Id

    Gene Info:

    Publications:
    Hosokawa et al., 1997, Cloning and characterization of a brain-specific cationic amino acid transporter., J. Biol. Chem.
    Humphrey et al., 2006, Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

  • Pharos: SLC7A3

    • Version: 03-September-2020

    Alternate Names:
    Cationic amino acid transporter 3 Gene Name
    Q8WY07 UniProt ID

    Gene Info:

    Gene Categories:
    TRANSPORTER

    Publications:

  • GO: SLC7A3

    • Version: 05-September-2020

    Alternate Names:
    ATRC3 GO Gene Synonym
    CAT3 GO Gene Synonym

    Gene Info:

    Gene Categories:
    EXTERNAL SIDE OF PLASMA MEMBRANE

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21