DGIdb - SLC7A3 Gene Record

SLC7A3 84889 Druggable Genome

Alternate Names:

84889
SOLUTE CARRIER FAMILY 7 MEMBER 3
SLC7A3
ATRC3
CAT-3
CAT3
300443
11061
ENSG00000165349
OTTHUMG00000021780
CATIONIC AMINO ACID TRANSPORTER 3 (CAT-3) (SOLUTE CARRIER FAMILY 7 MEMBER 3) (CATIONIC AMINO ACID TRANSPORTER Y+). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8WY07]
CTR3_HUMAN
BE0000136
Q8WY07
893
Cationic amino acid transporter 3

Gene Info:

Human Readable Name	DRUGGABLE GENOME
GuideToPharmacology Gene Category Name	SLC7 family
GuideToPharmacology Gene Category ID	169
Gene Biotype	PROTEIN_CODING

(2 More Sources)

Gene Categories: Category Details

TRANSPORTER
EXTERNAL SIDE OF PLASMA MEMBRANE
DRUGGABLE GENOME

Publications:

Huang et al., 2007, The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway., J. Neurosci.
Rotmann et al., 2007, Activation of classical protein kinase C decreases transport via systems y+ and y+L., Am. J. Physiol., Cell Physiol.
Hosokawa et al., 1997, Cloning and characterization of a brain-specific cationic amino acid transporter., J. Biol. Chem.
Humphrey et al., 2006, Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

LYSINE SLC7A3

Interaction Score: 20.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9079705 16406639 17139284 17016423

Sources:
DrugBank
ARGININE SLC7A3

Interaction Score: 8.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17234578 17329401

Sources:
DrugBank

Ensembl: ENSG00000165349
- Version: 101_38
Alternate Names:

SLC7A3 Ensembl Gene Name

Gene Info:

Gene Biotype PROTEIN_CODING

Publications:

RussLampel: ENSG00000165349

Version: 26-July-2011

Alternate Names:

CTR3_HUMAN Display Id

CATIONIC AMINO ACID TRANSPORTER 3 (CAT-3) (SOLUTE CARRIER FAMILY 7 MEMBER 3) (CATIONIC AMINO ACID TRANSPORTER Y+). [SOURCE:UNIPROT/SWISSPROT;ACC:Q8WY07] Description

ENSG00000165349 Ensembl Gene Id

Gene Info:

Human Readable Name DRUGGABLE GENOME

Gene Categories:

DRUGGABLE GENOME

Publications:

GuideToPharmacology: 84889
- Version: 29-September-2020
Alternate Names:

11061 HUGO Gene ID

11061 HUGO Gene Symbol

solute carrier family 7 member 3 HUGO Gene Name

Gene Info:

GuideToPharmacology Gene Category Name SLC7 family

GuideToPharmacology Gene Category ID 169

Gene Categories:

TRANSPORTER

Publications:

DrugBank: BE0000136

Version: 5.1.7

Alternate Names:

SLC7A3 DrugBank Gene Name

Q8WY07 UniProt Accession

84889 Entrez Gene Id

Gene Info:

Publications:

Hosokawa et al., 1997, Cloning and characterization of a brain-specific cationic amino acid transporter., J. Biol. Chem.

Humphrey et al., 2006, Lysine deficiency and feed restriction independently alter cationic amino acid transporter expression in chickens (Gallus gallus domesticus)., Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

Pharos: SLC7A3
- Version: 03-September-2020
Alternate Names:

Cationic amino acid transporter 3 Gene Name

Q8WY07 UniProt ID

Gene Info:

Gene Categories:

TRANSPORTER

Publications:
GO: SLC7A3
- Version: 05-September-2020
Alternate Names:

ATRC3 GO Gene Synonym

CAT3 GO Gene Synonym

Gene Info:

Gene Categories:

EXTERNAL SIDE OF PLASMA MEMBRANE

Publications: